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Entry version 49 (29 Sep 2021)
Sequence version 1 (03 Apr 2013)
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Protein
Submitted name:

ADP-ribosylation factor GTPase-activating protein 2

Gene

TREES_T100014292

Organism
Tupaia chinensis (Chinese tree shrew)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ADP-ribosylation factor GTPase-activating protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TREES_T100014292Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTupaia chinensis (Chinese tree shrew)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri246437 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresScandentiaTupaiidaeTupaia

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
246437.XP_006157858.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 339F-BARInterPro annotationAdd BLAST271
Domaini424 – 485SH3InterPro annotationAdd BLAST62
Domaini484 – 575Arf-GAPInterPro annotationAdd BLAST92

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni214 – 242DisorderedSequence analysisAdd BLAST29
Regioni366 – 421DisorderedSequence analysisAdd BLAST56
Regioni596 – 660DisorderedSequence analysisAdd BLAST65
Regioni849 – 878DisorderedSequence analysisAdd BLAST30
Regioni898 – 931DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili728 – 762Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi214 – 231Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi385 – 409Polar residuesSequence analysisAdd BLAST25
Compositional biasi619 – 639Polar residuesSequence analysisAdd BLAST21
Compositional biasi858 – 874Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

ANK repeatARBA annotation, Coiled coilPROSITE-ProRule annotationARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0706, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
L9JIB1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.220.150, 1 hit
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR031160, F_BAR
IPR001060, FCH_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01412, ArfGap, 1 hit
PF00611, FCH, 1 hit
PF14604, SH3_9, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00405, REVINTRACTNG
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00105, ArfGap, 1 hit
SM00055, FCH, 1 hit
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit
SSF57863, SSF57863, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50115, ARFGAP, 1 hit
PS51741, F_BAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

L9JIB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVEARVRQP RAREGSLLRP AEAYRIPGLQ GDTLDLLLNF SAGDWDSPKS
60 70 80 90 100
ATIPCCGDTM APEEDAGGEA LGGSFWEAGN YRRTVQRVED GHRLCGDLVS
110 120 130 140 150
CFQERARIEK AYAQQLADWA RKWRGTVEKG PQYGTLEKAW HAFFTAAERL
160 170 180 190 200
STLHLEVREK LQGQDSERVR AWQRGAFHRP VLGGFRESRA AEDGFRKAQK
210 220 230 240 250
PWLKRLKEVE ASKKSYHAAR KDEKTAQTRE SHAKADSAVS QEQLRKLQER
260 270 280 290 300
VERCTKEADK MKTQYEQTLV ELHRYTPRYM EDMEQAFESC QAAERQRLVF
310 320 330 340 350
FRDMLLTFHQ HLDLSSSEKF QELHRDLHQS IEAASDEEDL RWWRSTHGPG
360 370 380 390 400
MAMNWPQFEA CEWSLDTQRP ISRKEKGGRS PDEVTLTSIV PTRDGTAPPS
410 420 430 440 450
QSPASPGSGQ EEEWSDEESP RKAAAGVRVR ALYDYAGQEA DELSFRAGEE
460 470 480 490 500
LLKMSEEDEQ GWCQGQLQSG RIGLYPANYV ECACFDCGAK NPSWASITYG
510 520 530 540 550
VFLCIDCSGV HRSLGVHLSF IRSTELDSNW NWFQLRCMQV GGNANATAFF
560 570 580 590 600
RQHGCTASDA NTKYNSRAAQ MYREKIRQLG SAALARHGTD LWIDNMNSAA
610 620 630 640 650
SHSPEKKDSD FFTEHTQPPA WDTPATDSSG TQEPASSAES GGLAQPEHGP
660 670 680 690 700
NTDLLGSSPK ASLELKSSII GKKKPAAAKK GLGAKKGLGA QKVSSQSFSE
710 720 730 740 750
IERQAQVAEK LREQQAADAK QQAEESMVAS MRLAYQELQI DRKKEEKKLQ
760 770 780 790 800
NLEGKKREQA ERLGMGLVSR SSVSHSVLSE MQVIEQETPV SAKSSRSQLD
810 820 830 840 850
LFDDVGTFAS GPPKYKDNPF SLGDSFSSRW DTDATWGLDR VEEKEPEVTI
860 870 880 890 900
SSIRPVSERA TNRREVESRS SGLESSEARQ KFAGAKAISS DMFFGREVDS
910 920 930 940 950
EPADPQALPF LHHSTKPGLG SSSSQAAAPX XXXXXXXXXX LFGDVDAAHG
960 970 980 990 1000
AGSVSLGNVL PTADIAQFKQ GVKSVAGKMA VLANGVMNSL QPKAPSSSAL
1010 1020 1030 1040 1050
CCREVRCSLD LTTLLYAEER ASVSRSCSWA TQPWGRGLAG CLGTRHGNRR

DRDPTHGA
Length:1,058
Mass (Da):117,131
Last modified:April 3, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DFFD1702E59A45A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KB321021 Genomic DNA Translation: ELW48857.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB321021 Genomic DNA Translation: ELW48857.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi246437.XP_006157858.1

Phylogenomic databases

eggNOGiKOG0706, Eukaryota
InParanoidiL9JIB1

Family and domain databases

Gene3Di1.10.220.150, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR037278, ARFGAP/RecO
IPR001164, ArfGAP_dom
IPR038508, ArfGAP_dom_sf
IPR031160, F_BAR
IPR001060, FCH_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF01412, ArfGap, 1 hit
PF00611, FCH, 1 hit
PF14604, SH3_9, 1 hit
PRINTSiPR00405, REVINTRACTNG
PR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00105, ArfGap, 1 hit
SM00055, FCH, 1 hit
SM00326, SH3, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF50044, SSF50044, 1 hit
SSF57863, SSF57863, 1 hit
PROSITEiView protein in PROSITE
PS50115, ARFGAP, 1 hit
PS51741, F_BAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL9JIB1_TUPCH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: L9JIB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: September 29, 2021
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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