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Protein
Submitted name:

Acetylcholine receptor subunit beta

Gene

M91_13037

Organism
Bos mutus (wild yak)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Acetylcholine receptor subunit betaImported
Gene namesi
ORF Names:M91_13037Imported
OrganismiBos mutus (wild yak)Imported
Taxonomic identifieri72004 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei247 – 271HelicalSequence analysisAdd BLAST25
Transmembranei278 – 296HelicalSequence analysisAdd BLAST19
Transmembranei308 – 333HelicalSequence analysisAdd BLAST26
Transmembranei474 – 496HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500399243725 – 505Sequence analysisAdd BLAST481

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliL8IX34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 246Neur_chan_LBDInterPro annotationAdd BLAST218
Domaini253 – 491Neur_chan_membInterPro annotationAdd BLAST239

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KOiK04812

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

L8IX34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPGALLLLL LGVLGAHLAP GARGSEAEGR LREKLFSGYD STVRPAREVG
60 70 80 90 100
DRVWVSIGLT LAQLISLNEK DEEMSTKVYL DLEWTDYRLS WDPEEHEGID
110 120 130 140 150
SLRISAESVW LPDVVLLNNN DGNFDVALDI NVVVSSDGSM RWQPPGIYRS
160 170 180 190 200
SCSIQVTYFP FDWQNCTMVF SSYSYDSSEV SLQTGLSPEG QERQEVYIHE
210 220 230 240 250
GTFIENGQWE IIHKPSRLIQ PSVDPRGGGE GRREEVTFYL IIRRKPLFYL
260 270 280 290 300
VNVIAPCILI TLLAIFVFYL PPDAGEKMGL SIFALLTLTV FLLLLADKVP
310 320 330 340 350
ETSLSVPIII KYLMFTMVLV TFSVILSVVV LNLHHRSPHT HQMPLWVRQI
360 370 380 390 400
FIHKLPLYLG LKRPKPERDQ MQEPPSIAPR DSPGSGWGRG TDEYFIRKPP
410 420 430 440 450
NDFLFPKPNR FQPELSAPDL RRFIDGPNRA VGLPPELREV VSSISYIARQ
460 470 480 490 500
LQEQEDHDAL KEDWQFVAMV VDRLFLWTFI IFTSVGTLVI FLDATYHLPP

ADPFP
Length:505
Mass (Da):57,324
Last modified:April 3, 2013 - v1
Checksum:i66C18552A6700D6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH880575 Genomic DNA Translation: ELR60558.1
RefSeqiXP_005889998.1, XM_005889936.2

Genome annotation databases

GeneIDi102268214
KEGGibom:102268214

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH880575 Genomic DNA Translation: ELR60558.1
RefSeqiXP_005889998.1, XM_005889936.2

3D structure databases

ProteinModelPortaliL8IX34
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102268214
KEGGibom:102268214

Organism-specific databases

CTDi1140

Phylogenomic databases

KOiK04812

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiL8IX34_9CETA
AccessioniPrimary (citable) accession number: L8IX34
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: February 28, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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