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Protein

Claudin

Gene

M91_01067

Organism
Bos mutus (wild yak)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
ORF Names:M91_01067Imported
OrganismiBos mutus (wild yak)Imported
Taxonomic identifieri72004 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 105HelicalUniRule annotationAdd BLAST27
Transmembranei117 – 140HelicalUniRule annotationAdd BLAST24
Transmembranei160 – 183HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

KOiK06087

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003550 Claudin4
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01379 CLAUDIN4
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

L8ITH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASMGLQVMG IALAVLGWLG AILSCALPMW RVTAFIGSNI VTSQTIWEGL
60 70 80 90 100
WMNCVVQSTG QMQCKVYDSL LALPQDLQAA RALIVICIIL AVFGVLLSVV
110 120 130 140 150
GGKCTNCVDD ESSKAKIMIV AGVVFLLAGL LVMVPVSWTA NNVIRDFYNP
160 170 180 190 200
LVASGQKREM GASLYVGWAA AGLLILGGAL LCFNCPPRND KPYSAKYSAA

RSAPASNYV
Length:209
Mass (Da):22,165
Last modified:April 3, 2013 - v1
Checksum:iBB234586BBAEE1F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH880833 Genomic DNA Translation: ELR58477.1
RefSeqiXP_005892912.1, XM_005892850.2

Genome annotation databases

GeneIDi102264749
KEGGibom:102264749

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH880833 Genomic DNA Translation: ELR58477.1
RefSeqiXP_005892912.1, XM_005892850.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102264749
KEGGibom:102264749

Organism-specific databases

CTDi1364

Phylogenomic databases

KOiK06087

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003550 Claudin4
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01379 CLAUDIN4
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiL8ITH0_9CETA
AccessioniPrimary (citable) accession number: L8ITH0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: June 7, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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