M91_08056

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
double-stranded RNA binding Source: Ensembl
eukaryotic translation initiation factor 2alpha kinase activity Source: Ensembl
identical protein binding Source: Ensembl

GO - Biological processⁱ

activation of MAPKK activity Source: Ensembl
cellular response to amino acid starvation Source: Ensembl
endoplasmic reticulum unfolded protein response Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of osteoblast proliferation Source: Ensembl
negative regulation of translation Source: Ensembl
negative regulation of viral genome replication Source: Ensembl
positive regulation of chemokine production Source: Ensembl
positive regulation of NF-kappaB transcription factor activity Source: Ensembl
positive regulation of NIK/NF-kappaB signaling Source: Ensembl
positive regulation of stress-activated MAPK cascade Source: Ensembl
protein autophosphorylation Source: Ensembl
regulation of hematopoietic stem cell differentiation Source: Ensembl
regulation of hematopoietic stem cell proliferation Source: Ensembl
regulation of NLRP3 inflammasome complex assembly Source: Ensembl
response to interferon-alpha Source: Ensembl
response to virus Source: Ensembl
translation Source: Ensembl

Keywordsⁱ

Molecular function	KinaseImported, RNA-bindingPROSITE-ProRule annotation, Transferase
Ligand	ATP-bindingARBA annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Interferon-induced, double-stranded RNA-activated protein kinaseImported
Gene namesⁱ	ORF Names:M91_08056Imported
Organismⁱ	Bos mutus (wild yak)Imported
Taxonomic identifierⁱ	72004 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos
Proteomesⁱ	UP000011080 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

GO - Cellular component

Interactionⁱ

GO - Molecular functionⁱ

identical protein binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	9 – 77	DRBMInterPro annotationAdd BLAST	69
Domainⁱ	100 – 167	DRBMInterPro annotationAdd BLAST	68
Domainⁱ	263 – 522	Protein kinaseInterPro annotationAdd BLAST	260

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	184 – 236	DisorderedSequence analysisAdd BLAST		53

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00048, DSRM, 2 hits
InterProⁱ	View protein in InterPro IPR014720, dsRBD_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00035, dsrm, 2 hits PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00358, DSRM, 2 hits SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50137, DS_RBD, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

L8I613-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MATGRSPCFY IEELNKYQQK NCVEVRYCEL AKTGPPHNFR FTYQVIIDDK 
        60         70         80         90        100
EYPQTEGRSK KEAKNAAAKL ALEIINKDRK SVSFSSQLTT NIPEGPPIEN 
       110        120        130        140        150
YIGRLNTISQ KKNLCVTYEE CKSKGDGPEG FHYICKIGQE EYGSGVGSTK 
       160        170        180        190        200
QEAKQLAAKL AYEKIESETM RDCFSAACGD VERNSPAVST SSSESPSENG 
       210        220        230        240        250
FSTNASERSD NNSGTLNSSS VSPGDGSRNN SRKVKRSLAP TFVSPVKTEG 
       260        270        280        290        300
NIYSVNERLV NDFTEVTPIG SGGFGQVFKA KHKIDKKTYV IKCVKYNSEK 
       310        320        330        340        350
VEREVKALAT LNHPNIVHYH SCWDGHDYDP EQSLNSSRSK TRCLFIQMEY 
       360        370        380        390        400
CDKGTLDQWI EKRRGKKPDK RLALDFFQQI TTGVHYIHSE QLIHRDLKPG 
       410        420        430        440        450
NIFLVAMNQI KIGDFGLVTY LKNDETRTSK KGTLRYMSPE QLSSVKDYGN 
       460        470        480        490        500
EVDIYALGLI LAELLHICPT SLETQKFFDD LRNGRLDVFD DKEKDLLEKL 
       510        520        530 
LSVDPKKRPT ASEILKTLKE WNNVTEKKKR NTC

Length:533

Mass (Da):60,203

Last modified:April 3, 2013 - v1

Checksum:ⁱ55B1DB673B765A5B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JH881848 Genomic DNA Translation: ELR51925.1
NCBI Reference Sequences More...RefSeqⁱ	XP_005901968.1, XM_005901906.1

Genome annotation databases

Ensemblⁱ	ENSBMUT00000020987; ENSBMUP00000018158; ENSBMUG00000013742
GeneIDⁱ	102281444
KEGGⁱ	bom:102281444

Protein	Similar proteins		Species	Score	Length	Source
L8I613	Uncharacterized protein		wild yak		552	UniRef100_A0A6B0RSB2

Protein	Similar proteins		Species	Score	Length	Source
L8I613	Eukaryotic translation initiation factor 2-alpha kinase 2		BOVIN		533	UniRef90_A0JNE6
Uncharacterized protein		BOBOX		533
Uncharacterized protein		wild yak		552
interferon-induced, double-stranded RNA-activated protein kinase		BOSIN		533
interferon-induced, double-stranded RNA-activated protein kinase		Bison bison bison		533
+9

Protein	Similar proteins		Species	Score	Length	Source
L8I613	Eukaryotic translation initiation factor 2-alpha kinase 2		BOVIN		533	UniRef50_A0JNE6
Uncharacterized protein		BOBOX		533
Uncharacterized protein		wild yak		552
interferon-induced, double-stranded RNA-activated protein kinase		Bison bison bison		533
interferon-induced, double-stranded RNA-activated protein kinase		BOSIN		533
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JH881848 Genomic DNA Translation: ELR51925.1
RefSeqⁱ	XP_005901968.1, XM_005901906.1

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSBMUT00000020987; ENSBMUP00000018158; ENSBMUG00000013742
GeneIDⁱ	102281444
KEGGⁱ	bom:102281444

Organism-specific databases

CTDⁱ	5610

CTDⁱ

5610

Family and domain databases

CDDⁱ	cd00048, DSRM, 2 hits
InterProⁱ	View protein in InterPro IPR014720, dsRBD_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00035, dsrm, 2 hits PF00069, Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00358, DSRM, 2 hits SM00220, S_TKc, 1 hit
SUPFAMⁱ	SSF56112, SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50137, DS_RBD, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	L8I613_9CETA
Accessionⁱ	L8I613Primary (citable) accession number: L8I613
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 3, 2013
	Last sequence update:	April 3, 2013
	Last modified:	December 2, 2020
	This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB - L8I613 (L8I613_9CETA)

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Interferon-induced, double-stranded RNA-activated protein kinase

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Cytosol

Other locations

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Region

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

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Supporting data

UniProtKB - L8I613 (L8I613_9CETA)

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Interferon-induced, double-stranded RNA-activated protein kinase

M91_08056

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Cytosol

Other locations

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Family and domain databases

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Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ