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UniProtKB - L8HJ59 (L8HJ59_ACACA)
Protein
F-actin-capping protein subunit beta
Gene
ACA1_333210
Organism
Acanthamoeba castellanii str. Neff
Status
Functioni
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- actin cytoskeleton organization Source: InterPro
- barbed-end actin filament capping Source: UniProtKB-UniRule
Keywordsi
Molecular function | Actin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit betaUniRule annotation |
Gene namesi | ORF Names:ACA1_333210Imported |
Organismi | Acanthamoeba castellanii str. NeffImported |
Taxonomic identifieri | 1257118 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Discosea › Longamoebia › Centramoebida › Acanthamoebidae › Acanthamoeba › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | AmoebaDB:ACA1_333210 |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
Cytoskeleton
- F-actin capping protein complex Source: UniProtKB-UniRule
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationARBA annotationInteractioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 1257118.L8HJ59 |
Structurei
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 1076134at2759 |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 3.90.1150.210, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
i Sequence
Sequence statusi: Complete.
L8HJ59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSELDCALD LMRRMPPSSI EDNLAGLIDL VPDLTEQLLS MVDQPLKVAH
60 70 80 90 100
DSQARRDYLL CDYNRDGDSY RSPWTNKYDP SLPDGALPSA QLRQLEVQAN
110 120 130 140 150
EVFDIYRDLY FEGGVSSVYC WDLDDGFAAV VLIKKTQDQS KKGQPMKGTW
160 170 180 190 200
DSIHVVEVVD KGKNAHYKLT STVMLFIETE TKETGRVTLA GSLTRQARHF
210 220 230 240 250
LHDEKDFPVD KVNPHVANIG RMIEDMELKL RTTLQTIYFG KTKDIVNELR
260 270
QVMPVSVLKS RSALQQQIAG AIGGRGN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KB007819 Genomic DNA Translation: ELR24441.1 |
RefSeqi | XP_004355015.1, XM_004354963.1 |
Genome annotation databases
EnsemblProtistsi | ELR24441; ELR24441; ACA1_333210 |
GeneIDi | 14925464 |
KEGGi | acan:ACA1_333210 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KB007819 Genomic DNA Translation: ELR24441.1 |
RefSeqi | XP_004355015.1, XM_004354963.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 1257118.L8HJ59 |
Genome annotation databases
EnsemblProtistsi | ELR24441; ELR24441; ACA1_333210 |
GeneIDi | 14925464 |
KEGGi | acan:ACA1_333210 |
Organism-specific databases
VEuPathDBi | AmoebaDB:ACA1_333210 |
Phylogenomic databases
OrthoDBi | 1076134at2759 |
Family and domain databases
Gene3Di | 1.20.58.570, 1 hit 3.90.1150.210, 1 hit |
InterProi | View protein in InterPro IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR001698, CAPZB IPR043175, CAPZB_N IPR019771, F-actin_capping_bsu_CS |
PANTHERi | PTHR10619, PTHR10619, 1 hit |
Pfami | View protein in Pfam PF01115, F_actin_cap_B, 1 hit |
PRINTSi | PR00192, FACTINCAPB |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00231, F_ACTIN_CAPPING_BETA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | L8HJ59_ACACA | |
Accessioni | L8HJ59Primary (citable) accession number: L8HJ59 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | January 19, 2022 | |
This is version 26 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |