We are aiming to switch to the new UniProt website on Monday, May 9. Please explore and share your feedback.
Take me to the new website.
UniProtKB - L8H1E5 (L8H1E5_ACACA)
Protein
F-actin-capping protein subunit alpha
Gene
ACA1_265330
Organism
Acanthamoeba castellanii str. Neff
Status
Functioni
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
GO - Biological processi
- barbed-end actin filament capping Source: UniProtKB-UniRule
Keywordsi
Molecular function | Actin cappingUniRule annotation, Actin-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: F-actin-capping protein subunit alphaUniRule annotation |
Gene namesi | ORF Names:ACA1_265330Imported |
Organismi | Acanthamoeba castellanii str. NeffImported |
Taxonomic identifieri | 1257118 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Discosea › Longamoebia › Centramoebida › Acanthamoebidae › Acanthamoeba › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | AmoebaDB:ACA1_265330 |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit.
UniRule annotationGO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 1257118.L8H1E5 |
Structurei
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 1085166at2759 |
Family and domain databases
Gene3Di | 3.30.1140.60, 1 hit 3.90.1150.210, 1 hit |
InterProi | View protein in InterPro IPR002189, CapZ_alpha IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR042489, CapZ_alpha_1 IPR017865, F-actin_cap_asu_CS |
PANTHERi | PTHR10653, PTHR10653, 1 hit |
Pfami | View protein in Pfam PF01267, F-actin_cap_A, 1 hit |
PRINTSi | PR00191, FACTINCAPA |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00748, F_ACTIN_CAPPING_A_1, 1 hit PS00749, F_ACTIN_CAPPING_A_2, 1 hit |
i Sequence
Sequence statusi: Complete.
L8H1E5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDITQEEIV EIVTNFLLNS PPGEFMEVVT DVRGLLPDES ILNDSAPATF
60 70 80 90 100
REYNTDQMLQ MQSPGNPHKF LITKFGEVGN GEYLDPRGRQ VVHFDHIRQE
110 120 130 140 150
VTGSRPISGE LDNSVESFRA AFDDKATEYT NEHYQNGTAT IYGKKEGGSV
160 170 180 190 200
VVTICISSAR FNPNNFCGGN VDISGVLKVN VHYYEDGNVQ LNTETPVKIS
210 220 230 240 250
ATGSDARGLA DAVVKAIDKA ESNFHKSLET SYNTMGDTTF KALRRVLPIT
260 270 280
RTKIDWTKIQ NYKSGGDAGG KAAASRGVRN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KB007933 Genomic DNA Translation: ELR19329.1 |
RefSeqi | XP_004341414.1, XM_004341366.1 |
Genome annotation databases
EnsemblProtistsi | ELR19329; ELR19329; ACA1_265330 |
GeneIDi | 14920106 |
KEGGi | acan:ACA1_265330 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KB007933 Genomic DNA Translation: ELR19329.1 |
RefSeqi | XP_004341414.1, XM_004341366.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 1257118.L8H1E5 |
Genome annotation databases
EnsemblProtistsi | ELR19329; ELR19329; ACA1_265330 |
GeneIDi | 14920106 |
KEGGi | acan:ACA1_265330 |
Organism-specific databases
VEuPathDBi | AmoebaDB:ACA1_265330 |
Phylogenomic databases
OrthoDBi | 1085166at2759 |
Family and domain databases
Gene3Di | 3.30.1140.60, 1 hit 3.90.1150.210, 1 hit |
InterProi | View protein in InterPro IPR002189, CapZ_alpha IPR037282, CapZ_alpha/beta IPR042276, CapZ_alpha/beta_2 IPR042489, CapZ_alpha_1 IPR017865, F-actin_cap_asu_CS |
PANTHERi | PTHR10653, PTHR10653, 1 hit |
Pfami | View protein in Pfam PF01267, F-actin_cap_A, 1 hit |
PRINTSi | PR00191, FACTINCAPA |
SUPFAMi | SSF90096, SSF90096, 1 hit |
PROSITEi | View protein in PROSITE PS00748, F_ACTIN_CAPPING_A_1, 1 hit PS00749, F_ACTIN_CAPPING_A_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | L8H1E5_ACACA | |
Accessioni | L8H1E5Primary (citable) accession number: L8H1E5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | January 19, 2022 | |
This is version 34 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |