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1 to 25 of 73  Show
  1. 1
    "Direct detection of alternative open reading frames translation products in human significantly expands the proteome."
    Vanderperre B., Lucier J.-F., Motard J., Tremblay G., Vanderperre S., Wisztorski M., Salzet M., Boisvert F.-M., Roucou X.
    PLoS ONE 8:E70698-E70698(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).

    This publication is cited by 1065 other entries.

  2. 2
    "DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."
    Nishihara H., Maeda M., Oda A., Tsuda M., Sawa H., Nagashima K., Tanaka S.
    Blood 100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.
    Source: GeneRIF:1399.

    This publication is cited by 2 and mapped to 10 other entries.

  3. 3
    Category: Interaction.
    Annotation: directs ASAP1 to peripheral focal adhesions in platelets.
    Source: GeneRIF:1399.

    This publication is mapped to 6 other entries.

  4. 4
    "Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases."
    Li L., Guris D.L., Okura M., Imamoto A.
    Mol Cell Biol 23:2883-2892(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: CrkL plays a specific role in integrin-induced migration as a downstream mediator of Src.
    Source: GeneRIF:1399.

    This publication is mapped to 5 other entries.

  5. 5
    "Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b."
    Zhang W., Shao Y., Fang D., Huang J., Jeon M.S., Liu Y.C.
    J Biol Chem 278:23978-23983(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells.
    Source: GeneRIF:1399.

    This publication is mapped to 41 other entries.

  6. 6
    "Mutational analysis of the interaction between insulin receptor and IGF-I receptor with c-Crk and Crk-L in a yeast two-hybrid system."
    Klammt J., Barnikol-Oettler A., Kiess W.
    Biochem Biophys Res Commun 325:183-190(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: Data suggest that members of the insulin receptor family activate Crk isoforms Crk-II and Crk-L in a differential manner.
    Source: GeneRIF:1399.

    This publication is mapped to 7 other entries.

  7. 7
    "Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav."
    Lottin-Divoux S., Jean D., Le Romancer M., Frade R.
    Cell Signal 18:1219-1225(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: CD21 activation triggered Cbl tyrosine phosphorylation which interacts with SH2 domains of p85 subunit SH2 domains of Crk-L and with tyrosine phosphorylated Syk kinase. CD21 activation triggers dissociation of Cbl-Vav complex.
    Source: GeneRIF:1399.

    This publication is mapped to 30 other entries.

  8. 8
    "Three-dimensional structure prediction of the interaction of CD34 with the SH3 domain of Crk-L."
    Gangenahalli G.U., Singh V.K., Verma Y.K., Gupta P., Sharma R.K., Chandra R., Gulati S., Luthra P.M.
    Stem Cells Dev 14:470-477(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction, Family & Domains.
    Annotation: Results suggest that the interaction of the cytoplasmic tail of CD34 with the shallow proline-rich motif-binding groove of Crk-L is essential for the function of CD34 in stem cell development.
    Source: GeneRIF:1399.

    This publication is mapped to 9 other entries.

  9. 9
    "Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2."
    Patel H., Marley S.B., Gordon M.Y.
    Genes Chromosomes Cancer 45:1121-1129(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: By lysing primary hemopoietic cells at high pH BCR-ABL1 protein-degradative activity was inhibited & association between BCR-ABL1 protein in complexes with adaptor proteins CBL CRKL & GRB2 in primary chronic myeloid leukaemia material was demonstrated.
    Source: GeneRIF:1399.

    This publication is mapped to 38 other entries.

  10. 10
    "The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal."
    Harkiolaki M., Gilbert R.J., Jones E.Y., Feller S.M.
    Structure 14:1741-1753(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Family & Domains.
    Annotation: in CRKL an SH3 domain dimer formed through exchange of the first SH3 domain beta strand and suggest that partial unfolding of the SH3C is important for the relay of information in vivo.
    Source: GeneRIF:1399.

    This publication is mapped to 1 other entry.

  11. 11
    "Proapoptotic function of the nuclear Crk II adaptor protein."
    Kar B., Reichman C.T., Singh S., O'Connor J.P., Birge R.B.
    Biochemistry 46:10828-10840(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: Crk L is a bona fide nuclear signaling protein because of its ability to bind tyrosine-phosphorylated STAT5 and act as a transcriptional coactivator.
    Source: GeneRIF:1399.

    This publication is mapped to 17 other entries.

  12. 12
    "Subcellular distribution of p210(BCR-ABL) in CML cell lines and primary CD34+ CML cells."
    Patel H., Marley S.B., Greener L., Gordon M.Y.
    Leukemia 22:559-571(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Confocal laser scanning microscopy analysed the distribution and colocalization of CT10 regulator-like (CRKL) p210(BCR-ABL). CRKL-p210(BCR-ABL) foci were completely or partially associated touching or separate in different regions of the same cell.
    Source: GeneRIF:1399.

    This publication is mapped to 24 other entries.

  13. 13
    "Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling."
    Heikkinen L.S., Kazlauskas A., Melen K., Wagner R., Ziegler T., Julkunen I., Saksela K.
    J Biol Chem 283:5719-5727(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: the Spanish Flu virus resembles avian influenza A viruses in its ability to recruit Crk/CrkL to modulate host cell signaling.
    Source: GeneRIF:1399.

    This publication is mapped to 5 other entries.

  14. 14
    "MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1."
    Shen Q., Rahn J.J., Zhang J., Gunasekera N., Sun X., Shaw A.R., Hendzel M.J., Hoffman P., Bernier A., Hugh J.C.
    Mol Cancer Res 6:555-567(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: These findings suggest a novel MUC1-Src-CrkL-Rac1/Cdc42 signaling cascade following ICAM-1 ligation through which MUC1 regulates cytoskeletal reorganization and directed cell motility during cell migration.
    Source: GeneRIF:1399.

    This publication is mapped to 25 other entries.

  15. 15
    "The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1."
    Nolz J.C., Nacusi L.P., Segovis C.M., Medeiros R.B., Mitchell J.S., Shimizu Y., Billadeau D.D.
    J Cell Biol 182:1231-1244(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Results identify a mechanism by which the WAVE2 complex regulates T cell receptor signaling to Rap1 and integrin activation via Abl- and CrkL-C3G.
    Source: GeneRIF:1399.

    This publication is mapped to 43 other entries.

  16. 16
    "DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV."
    Sanders M.A., Ampasala D., Basson M.D.
    J. Biol. Chem. 284:27-35(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: along with DOCK1 DOCK5 is an important mediator of CrkII/CrkL regulation of Caco-2 spreading and migration on collagen IV.
    Source: GeneRIF:1399.

    This publication is cited by 3 and mapped to 10 other entries.

  17. 17
    "Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop."
    Seo J.H., Suenaga A., Hatakeyama M., Taiji M., Imamoto A.
    Mol Cell Biol 29:3076-3087(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: CRKL permits cells to bypass the strict need for adhesion in response to FGF8 through direct interaction with receptor.
    Source: GeneRIF:1399.

    This publication is mapped to 78 other entries.

  18. 18
    "PI3K links NKG2D signaling to a CrkL pathway involved in natural killer cell adhesion, polarity, and granule secretion."
    Segovis C.M., Schoon R.A., Dick C.J., Nacusi L.P., Leibson P.J., Billadeau D.D.
    J Immunol 182:6933-6942(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: an interaction between the regulatory subunit of PI3K p85 and the adaptor protein CrkL is required for efficient NKG2D-mediated cellular cytotoxicity.
    Source: GeneRIF:1399.

    This publication is mapped to 11 other entries.

  19. 19
    Category: Function, Pathology & Biotech.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:1399.

    This publication is mapped to 19059 other entries.

  20. 20
    Category: Function.
    Annotation: Findings indicate that amplification and resultant overexpression of CRKL contribute to diverse oncogenic phenotypes in lung cancer.
    Source: GeneRIF:1399.

    This publication is mapped to 1 other entry.

  21. 21
    "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
    Bailey S.D., Xie C., Do R., Montpetit A., Diaz R., Mohan V., Keavney B., Yusuf S., Gerstein H.C., Engert J.C., Anand S.
    Diabetes Care 33:2250-2253(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator).
    Source: GeneRIF:1399.

    This publication is mapped to 18922 other entries.

  22. 22
    "Crk and CrkL present with different expression and significance in epithelial ovarian carcinoma."
    Wang J., Che Y.L., Li G., Liu B., Shen T.M., Wang H., Linghu H.
    Mol Carcinog 50:506-515(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: differential binding selectivity of Crk and CrkL to their downstream partners Dock 180 and C3G was demonstrated in ovarian cancer cell line SKOV3 through coimmunoprecipitation.
    Source: GeneRIF:1399.

    This publication is mapped to 5 other entries.

  23. 23
    "The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge."
    He Y., Kapoor A., Cook S., Liu S., Xiang Y., Rao C.V., Kenis P.J., Wang F.
    J Cell Sci 124:2153-2164(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Lyn controls spatial activation of Rap1 by recruiting the CrkL-C3G protein complex to the leading edge.
    Source: GeneRIF:1399.

    This publication is mapped to 18 other entries.

  24. 24
    "CrkL is a co-activator of estrogen receptor alpha that enhances tumorigenic potential in cancer."
    Padmanabhan R.A., Nirmala L., Murali M., Laloraya M.
    Mol Endocrinol 25:1499-1512(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: The molecular signaling set off by ERalpha and CrkL association may have a central role in pregnancy and cancer.
    Source: GeneRIF:1399.

    This publication is mapped to 98 other entries.

  25. 25
    "Recurrent amplification in the 22q11 region in laryngeal squamous cell carcinoma results in overexpression of the CRKL but not the MAPK1 oncogene."
    Kostrzewska-Poczekaj M., Giefing M., Jarmuz M., Brauze D., Pelinska K., Grenman R., Bartochowska A., Szyfter W., Szyfter K.
    Cancer Biomark 8:11-19(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: These results suggest that CRKL but not MAPK1 is the target oncogene of the rare but recurrent amplification at 22q11.2 in laryngeal squamous cell carcinoma.
    Source: GeneRIF:1399.

    This publication is mapped to 1 other entry.

1 to 25 of 73  Show
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