We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - L8B7P7 (L8B7P7_HUMAN)
Protein
Submitted name:
ATL1-alpha zinc finger protein
Gene
ATL1-alpha
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- alpha-beta T cell differentiation Source: Ensembl
- commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
- epithelial cell morphogenesis Source: Ensembl
- keratinocyte development Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- olfactory bulb axon guidance Source: Ensembl
- positive T cell selection Source: Ensembl
- post-embryonic camera-type eye development Source: Ensembl
- regulation of keratinocyte proliferation Source: Ensembl
- regulation of lipid metabolic process Source: Ensembl
- regulation of neuron differentiation Source: Ensembl
- striatal medium spiny neuron differentiation Source: Ensembl
- T cell differentiation in thymus Source: Ensembl
- T cell receptor V(D)J recombination Source: Ensembl
- thymus development Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: ATL1-alpha zinc finger proteinImportedSubmitted name: B-cell CLL/lymphoma 11B (Zinc finger protein), isoform CRA_bImported |
Gene namesi | Name:ATL1-alphaImported Synonyms:BCL11BImported ORF Names:hCG_1657560Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000127152 |
Subcellular locationi
Nucleus
- SWI/SNF complex Source: Ensembl
Other locations
- neuron projection Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000127152, Expressed in forebrain and 178 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 221 – 244 | C2H2-typeInterPro annotationAdd BLAST | 24 | |
Domaini | 427 – 454 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 455 – 482 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 796 – 823 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 824 – 846 | C2H2-typeInterPro annotationAdd BLAST | 23 | |
Domaini | 854 – 877 | C2H2-typeInterPro annotationAdd BLAST | 24 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 370 – 428 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 471 – 583 | DisorderedSequence analysisAdd BLAST | 113 | |
Regioni | 653 – 680 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 737 – 794 | DisorderedSequence analysisAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 400 – 425 | Pro residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 511 – 527 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 528 – 547 | Acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 550 – 564 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 737 – 752 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
OMAi | QENMAGP |
OrthoDBi | 224109at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
i Sequence
Sequence statusi: Complete.
L8B7P7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRRKQGNPQ HLSQRELITP EADHVEAAIL EEDEGLEIEE PSGLGLMVGG
60 70 80 90 100
PDPDLLTCGQ CQMNFPLGDI LVFIEHKRKQ CGGSLGACYD KALDKDSPPP
110 120 130 140 150
SSRSELRKVS EPVEIGIQVT PDEDDHLLSP TKGICPKQEN IAGPCRPAQL
160 170 180 190 200
PAVAPIAASS HPHSSVITSP LRALGALPPC LPLPCCSARP VSGDGTQGEG
210 220 230 240 250
QTEAPFGCQC QLSGKDEPSS YICTTCKQPF NSAWFLLQHA QNTHGFRIYL
260 270 280 290 300
EPGPASSSLT PRLTIPPPLG PEAVAQSPLM NFLGDSNPFN LLRMTGPILR
310 320 330 340 350
DHPGFGEGRL PGTPPLFSPP PRHHLDPHRL SAEEMGLVAQ HPSAFDRVMR
360 370 380 390 400
LNPMAIDSPA MDFSRRLREL AGNSSTPPPV SPGRGNPMHR LLNPFQPSPK
410 420 430 440 450
SPFLSTPPLP PMPPGGTPPP QPPAKSKSCE FCGKTFKFQS NLIVHRRSHT
460 470 480 490 500
GEKPYKCQLC DHACSQASKL KRHMKTHMHK AGSLAGRSDD GLSAASSPEP
510 520 530 540 550
GTSELAGEGL KAADGDFRHH ESDPSLGHEP EEEDEEEEEE EEELLLENES
560 570 580 590 600
RPESSFSMDS ELSRNRENGG GGVPGVPGAG GGAAKALADE KALVLGKVME
610 620 630 640 650
NVGLGALPQY GELLADKQKR GAFLKRAAGG GDAGDDDDAG GCGDAGAGGA
660 670 680 690 700
VNGRGGGFAP GTEPFPGLFP RKPAPLPSPG LNSAAKRIKV EKDLELPPAA
710 720 730 740 750
LIPSENVYSQ WLVGYAASRH FMKDPFLGFT DARQSPFATS SEHSSENGSL
760 770 780 790 800
RFSTPPGDLL DGGLSGRSGT ASGGSTPHLG GPGPGRPSSK EGRRSDTCEY
810 820 830 840 850
CGKVFKNCSN LTVHRRSHTG ERPYKCELCN YACAQSSKLT RHMKTHGQIG
860 870 880 890
KEVYRCDICQ MPFSVYSTLE KHMKKWHGEH LLTNDVKIEQ AERS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041218 mRNA Translation: BAM78282.1 CH471061 Genomic DNA Translation: EAW81663.1 |
RefSeqi | NP_612808.1, NM_138576.3 |
Genome annotation databases
GeneIDi | 64919 |
KEGGi | hsa:64919 |
MANE-Selecti | ENST00000357195.8; ENSP00000349723.3; NM_138576.4; NP_612808.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB041218 mRNA Translation: BAM78282.1 CH471061 Genomic DNA Translation: EAW81663.1 |
RefSeqi | NP_612808.1, NM_138576.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 27407, 274 antibodies from 36 providers |
DNASUi | 64919 |
Genome annotation databases
GeneIDi | 64919 |
KEGGi | hsa:64919 |
MANE-Selecti | ENST00000357195.8; ENSP00000349723.3; NM_138576.4; NP_612808.1 |
Organism-specific databases
CTDi | 64919 |
VEuPathDBi | HostDB:ENSG00000127152 |
Phylogenomic databases
OMAi | QENMAGP |
OrthoDBi | 224109at2759 |
Miscellaneous databases
BioGRID-ORCSi | 64919, 11 hits in 1057 CRISPR screens |
ChiTaRSi | BCL11B, human |
GenomeRNAii | 64919 |
Gene expression databases
Bgeei | ENSG00000127152, Expressed in forebrain and 178 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | L8B7P7_HUMAN | |
Accessioni | L8B7P7Primary (citable) accession number: L8B7P7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | January 19, 2022 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |