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Protein

Gag polyprotein

Gene

gag

Organism
Human immunodeficiency virus 2
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinUniRule annotation
Biological processHost-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Viral release from host cell
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotationSAAS annotation
Gene namesi
Name:gagImported
OrganismiHuman immunodeficiency virus 2Imported
Taxonomic identifieri11709 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host cytoplasm UniRule annotationSAAS annotation
  • Host nucleus UniRule annotationSAAS annotation
  • Virion UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini390 – 405CCHC-typeInterPro annotationAdd BLAST16
Domaini412 – 427CCHC-typeInterPro annotationAdd BLAST16

Sequence similaritiesi

Belongs to the primate lentivirus group gag polyprotein family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30, 1 hit
1.10.150.90, 1 hit
1.10.375.10, 1 hit
InterProiView protein in InterPro
IPR000721 Gag_p24
IPR000071 Lentvrl_matrix_N
IPR012344 Matrix_HIV/RSV_N
IPR008916 Retrov_capsid_C
IPR008919 Retrov_capsid_N
IPR010999 Retrovr_matrix
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00540 Gag_p17, 1 hit
PF00607 Gag_p24, 1 hit
PF00098 zf-CCHC, 2 hits
PRINTSiPR00234 HIV1MATRIX
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 2 hits
SUPFAMiSSF47836 SSF47836, 1 hit
SSF47943 SSF47943, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 2 hits

Sequencei

Sequence statusi: Complete.

L8B2M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARNSVLRG KKADELEKIR LRPGGKKKYK LKHIVWAANE LDRFGLAESL
60 70 80 90 100
LESKEGCQRI LSVLNPLIPT GSENLKSLFN TVCVIWCLHA EEKVKDTEEA
110 120 130 140 150
KKLVQRHLVA ETGTAEKMPE TSRPTAPPSG KGGNFPVQQV GGNYVHVPLS
160 170 180 190 200
PRTLNAWVKL VEEKKFGAEV VPGFQALSEG CTPYDINQML NCVGDHQAAM
210 220 230 240 250
QIIREIINEE AAEWDAQHPI PGPLPAGQLR DPRGSDIAGT TSTVEEQLQW
260 270 280 290 300
MYRQPNPVPV GNIYRRWIQI GLQKCVRMYN PTNILDIKQG PKEPFQSYVD
310 320 330 340 350
RFYKSLRAEQ TDPAVKNWMT QTLLIQNANP DCKLVLKGLG MGPTLEEMLT
360 370 380 390 400
ACQGVGGPGQ KARLMAEALK EALTPAPIPF AAAQQRKTFK CWNCGKEGHS
410 420 430 440 450
ARQCRAPRRQ GCWKCGKQGH IMSNCPERQA GFLGISPRGK KPRNFPVAQA
460 470 480 490 500
PQGLIPTAPP ADPAMDLLEK YMQQGRRQRE QRERPYKEVT EDLLHLEQGE
510 520
TPHREATKDL LHLNSLFGED Q
Length:521
Mass (Da):58,186
Last modified:April 3, 2013 - v1
Checksum:iE3FEBBD75A8AC87B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB731743 Genomic DNA Translation: BAM76181.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Similar proteinsi

Entry informationi

Entry nameiL8B2M4_9HIV2
AccessioniPrimary (citable) accession number: L8B2M4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: July 18, 2018
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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