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Protein
Submitted name:

Tyrosinase (Oculocutaneous albinism IA), isoform CRA_a

Gene

TYR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseImported
LigandMetal-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosinase (Oculocutaneous albinism IA), isoform CRA_aImported
Gene namesi
Name:TYRImported
ORF Names:hCG_19690Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000077498.8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei474 – 500HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501430617718 – 529Sequence analysisAdd BLAST512

Proteomic databases

PRIDEiL8B082

Expressioni

Gene expression databases

BgeeiENSG00000077498
ExpressionAtlasiL8B082 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiL8B082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 219Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini383 – 394Tyrosinase_Cu-bdInterPro annotationAdd BLAST12

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEZU Eukaryota
ENOG410Y42I LUCA
KOiK00505
OMAiSFFSSWQ
OrthoDBiEOG091G03YR

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

L8B082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLAVLYCLL WSFQTSAGHF PRACVSSKNL MEKECCPPWS GDRSPCGQLS
60 70 80 90 100
GRGSCQNILL SNAPLGPQFP FTGVDDRESW PSVFYNRTCQ CSGNFMGFNC
110 120 130 140 150
GNCKFGFWGP NCTERRLLVR RNIFDLSAPE KDKFFAYLTL AKHTISSDYV
160 170 180 190 200
IPIGTYGQMK NGSTPMFNDI NIYDLFVWMH YYVSMDALLG GSEIWRDIDF
210 220 230 240 250
AHEAPAFLPW HRLFLLRWEQ EIQKLTGDEN FTIPYWDWRD AEKCDICTDE
260 270 280 290 300
YMGGQHPTNP NLLSPASFFS SWQIVCSRLE EYNSHQSLCN GTPEGPLRRN
310 320 330 340 350
PGNHDKSRTP RLPSSADVEF CLSLTQYESG SMDKAANFSF RNTLEGFASP
360 370 380 390 400
LTGIADASQS SMHNALHIYM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW
410 420 430 440 450
LRRHRPLQEV YPEANAPIGH NRESYMVPFI PLYRNGDFFI SSKDLGYDYS
460 470 480 490 500
YLQDSDPDSF QDYIKSYLEQ ASRIWSWLLG AAMVGAVLTA LLAGLVSLLC
510 520
RHKRKQLPEE KQPLLMEKED YHSLYQSHL
Length:529
Mass (Da):60,393
Last modified:April 3, 2013 - v1
Checksum:i67211A91608A59E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC201429 Genomic DNA Translation: AGV39051.1
KC201430 Genomic DNA Translation: AGV39052.1
KC201431 Genomic DNA Translation: AGV39053.1
KC201433 Genomic DNA Translation: AGV39055.1
KC201434 Genomic DNA Translation: AGV39056.1
KC201435 Genomic DNA Translation: AGV39057.1
KC201436 Genomic DNA Translation: AGV39058.1
KC201437 Genomic DNA Translation: AGV39059.1
KC201438 Genomic DNA Translation: AGV39060.1
KC201439 Genomic DNA Translation: AGV39061.1
KC201440 Genomic DNA Translation: AGV39062.1
KC201441 Genomic DNA Translation: AGV39063.1
KC201442 Genomic DNA Translation: AGV39064.1
KC201443 Genomic DNA Translation: AGV39065.1
KC201444 Genomic DNA Translation: AGV39066.1
KC201445 Genomic DNA Translation: AGV39067.1
KC201446 Genomic DNA Translation: AGV39068.1
KC201447 Genomic DNA Translation: AGV39069.1
KC201448 Genomic DNA Translation: AGV39070.1
KC201449 Genomic DNA Translation: AGV39071.1
KC201450 Genomic DNA Translation: AGV39072.1
KC201451 Genomic DNA Translation: AGV39073.1
KC201452 Genomic DNA Translation: AGV39074.1
KC201453 Genomic DNA Translation: AGV39075.1
KC201454 Genomic DNA Translation: AGV39076.1
KC201455 Genomic DNA Translation: AGV39077.1
KC201456 Genomic DNA Translation: AGV39078.1
KC201457 Genomic DNA Translation: AGV39079.1
KC201458 Genomic DNA Translation: AGV39080.1
KC201459 Genomic DNA Translation: AGV39081.1
KC201463 Genomic DNA Translation: AGV39085.1
KC201466 Genomic DNA Translation: AGV39088.1
KC201471 Genomic DNA Translation: AGV39093.1
KC201472 Genomic DNA Translation: AGV39094.1
KC201475 Genomic DNA Translation: AGV39097.1
KC201476 Genomic DNA Translation: AGV39098.1
KC201477 Genomic DNA Translation: AGV39099.1
KC201478 Genomic DNA Translation: AGV39100.1
KC201479 Genomic DNA Translation: AGV39101.1
KC201481 Genomic DNA Translation: AGV39103.1
KC201483 Genomic DNA Translation: AGV39105.1
KC201484 Genomic DNA Translation: AGV39106.1
KC201485 Genomic DNA Translation: AGV39107.1
KC201486 Genomic DNA Translation: AGV39108.1
KC201487 Genomic DNA Translation: AGV39109.1
KC201488 Genomic DNA Translation: AGV39110.1
KC201489 Genomic DNA Translation: AGV39111.1
KC201490 Genomic DNA Translation: AGV39112.1
KC201491 Genomic DNA Translation: AGV39113.1
KC201492 Genomic DNA Translation: AGV39114.1
KC201493 Genomic DNA Translation: AGV39115.1
KC201494 Genomic DNA Translation: AGV39116.1
KC201495 Genomic DNA Translation: AGV39117.1
KC201496 Genomic DNA Translation: AGV39118.1
KC201497 Genomic DNA Translation: AGV39119.1
KC201498 Genomic DNA Translation: AGV39120.1
KC201499 Genomic DNA Translation: AGV39121.1
KC201502 Genomic DNA Translation: AGV39124.1
KC201503 Genomic DNA Translation: AGV39125.1
KC201504 Genomic DNA Translation: AGV39126.1
KC201505 Genomic DNA Translation: AGV39127.1
KC201506 Genomic DNA Translation: AGV39128.1
KC201507 Genomic DNA Translation: AGV39129.1
KC201508 Genomic DNA Translation: AGV39130.1
KC201509 Genomic DNA Translation: AGV39131.1
KC201511 Genomic DNA Translation: AGV39133.1
KC201512 Genomic DNA Translation: AGV39134.1
KC201513 Genomic DNA Translation: AGV39135.1
KC201514 Genomic DNA Translation: AGV39136.1
KC201515 Genomic DNA Translation: AGV39137.1
KC201516 Genomic DNA Translation: AGV39138.1
KC201517 Genomic DNA Translation: AGV39139.1
KC201518 Genomic DNA Translation: AGV39140.1
KC201519 Genomic DNA Translation: AGV39141.1
KC201520 Genomic DNA Translation: AGV39142.1
KC201521 Genomic DNA Translation: AGV39143.1
KC201522 Genomic DNA Translation: AGV39144.1
KC201523 Genomic DNA Translation: AGV39145.1
KC201524 Genomic DNA Translation: AGV39146.1
KC201525 Genomic DNA Translation: AGV39147.1
KC201526 Genomic DNA Translation: AGV39148.1
KC201527 Genomic DNA Translation: AGV39149.1
KC201528 Genomic DNA Translation: AGV39150.1
KC201529 Genomic DNA Translation: AGV39151.1
KC201530 Genomic DNA Translation: AGV39152.1
KC201531 Genomic DNA Translation: AGV39153.1
KC201532 Genomic DNA Translation: AGV39154.1
KC201533 Genomic DNA Translation: AGV39155.1
KC201534 Genomic DNA Translation: AGV39156.1
KC201535 Genomic DNA Translation: AGV39157.1
KC201536 Genomic DNA Translation: AGV39158.1
KC201537 Genomic DNA Translation: AGV39159.1
KC201538 Genomic DNA Translation: AGV39160.1
KC201539 Genomic DNA Translation: AGV39161.1
KC201541 Genomic DNA Translation: AGV39163.1
KC201547 Genomic DNA Translation: AGV39169.1
KC201552 Genomic DNA Translation: AGV39174.1
KC201555 Genomic DNA Translation: AGV39177.1
KC201556 Genomic DNA Translation: AGV39178.1
KC201557 Genomic DNA Translation: AGV39179.1
KC201558 Genomic DNA Translation: AGV39180.1
KC201559 Genomic DNA Translation: AGV39181.1
KC201560 Genomic DNA Translation: AGV39182.1
KC201561 Genomic DNA Translation: AGV39183.1
KC201562 Genomic DNA Translation: AGV39184.1
KC201563 Genomic DNA Translation: AGV39185.1
KC201564 Genomic DNA Translation: AGV39186.1
KC201565 Genomic DNA Translation: AGV39187.1
KC201567 Genomic DNA Translation: AGV39189.1
KC201568 Genomic DNA Translation: AGV39190.1
KC201569 Genomic DNA Translation: AGV39191.1
KC201571 Genomic DNA Translation: AGV39193.1
KC201573 Genomic DNA Translation: AGV39195.1
KC201574 Genomic DNA Translation: AGV39196.1
KC201575 Genomic DNA Translation: AGV39197.1
KC201576 Genomic DNA Translation: AGV39198.1
KC201577 Genomic DNA Translation: AGV39199.1
KC201578 Genomic DNA Translation: AGV39200.1
KC201579 Genomic DNA Translation: AGV39201.1
KC201580 Genomic DNA Translation: AGV39202.1
KC201581 Genomic DNA Translation: AGV39203.1
KC201582 Genomic DNA Translation: AGV39204.1
KC201583 Genomic DNA Translation: AGV39205.1
KC201584 Genomic DNA Translation: AGV39206.1
KC201585 Genomic DNA Translation: AGV39207.1
KC201586 Genomic DNA Translation: AGV39208.1
KC201587 Genomic DNA Translation: AGV39209.1
KC201588 Genomic DNA Translation: AGV39210.1
AB775900 mRNA Translation: BAM75357.1
CH471185 Genomic DNA Translation: EAW59356.1
RefSeqiNP_000363.1, NM_000372.4
UniGeneiHs.503555

Genome annotation databases

GeneIDi7299
KEGGihsa:7299

Similar proteinsi

Entry informationi

Entry nameiL8B082_HUMAN
AccessioniPrimary (citable) accession number: L8B082
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: June 20, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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