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Entry version 70 (17 Jun 2020)
Sequence version 1 (03 Apr 2013)
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Protein
Submitted name:

Tyrosinase

Gene

TYR

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported
LigandMetal-bindingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TyrosinaseImported (EC:1.14.18.1Imported)
Submitted name:
Tyrosinase (Oculocutaneous albinism IA), isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TYRImported
ORF Names:hCG_19690Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000077498.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei474 – 500HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501430617718 – 529Sequence analysisAdd BLAST512

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000077498 Expressed in pigmented layer of retina and 27 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
L8B082 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
L8B082

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini202 – 219Tyrosinase_Cu-bdInterPro annotationAdd BLAST18
Domaini383 – 394Tyrosinase_Cu-bdInterPro annotationAdd BLAST12

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni287 – 313DisorderedSequence analysisAdd BLAST27

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEZU Eukaryota
ENOG410Y42I LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038693_1_0_1

KEGG Orthology (KO)

More...
KOi
K00505

Identification of Orthologs from Complete Genome Data

More...
OMAi
MNGSMSQ

Database of Orthologous Groups

More...
OrthoDBi
881347at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00264 Tyrosinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00092 TYROSINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48056 SSF48056, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

L8B082-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLAVLYCLL WSFQTSAGHF PRACVSSKNL MEKECCPPWS GDRSPCGQLS
60 70 80 90 100
GRGSCQNILL SNAPLGPQFP FTGVDDRESW PSVFYNRTCQ CSGNFMGFNC
110 120 130 140 150
GNCKFGFWGP NCTERRLLVR RNIFDLSAPE KDKFFAYLTL AKHTISSDYV
160 170 180 190 200
IPIGTYGQMK NGSTPMFNDI NIYDLFVWMH YYVSMDALLG GSEIWRDIDF
210 220 230 240 250
AHEAPAFLPW HRLFLLRWEQ EIQKLTGDEN FTIPYWDWRD AEKCDICTDE
260 270 280 290 300
YMGGQHPTNP NLLSPASFFS SWQIVCSRLE EYNSHQSLCN GTPEGPLRRN
310 320 330 340 350
PGNHDKSRTP RLPSSADVEF CLSLTQYESG SMDKAANFSF RNTLEGFASP
360 370 380 390 400
LTGIADASQS SMHNALHIYM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW
410 420 430 440 450
LRRHRPLQEV YPEANAPIGH NRESYMVPFI PLYRNGDFFI SSKDLGYDYS
460 470 480 490 500
YLQDSDPDSF QDYIKSYLEQ ASRIWSWLLG AAMVGAVLTA LLAGLVSLLC
510 520
RHKRKQLPEE KQPLLMEKED YHSLYQSHL
Length:529
Mass (Da):60,393
Last modified:April 3, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67211A91608A59E1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KC201429 Genomic DNA Translation: AGV39051.1
KC201430 Genomic DNA Translation: AGV39052.1
KC201431 Genomic DNA Translation: AGV39053.1
KC201433 Genomic DNA Translation: AGV39055.1
KC201434 Genomic DNA Translation: AGV39056.1
KC201435 Genomic DNA Translation: AGV39057.1
KC201436 Genomic DNA Translation: AGV39058.1
KC201437 Genomic DNA Translation: AGV39059.1
KC201438 Genomic DNA Translation: AGV39060.1
KC201439 Genomic DNA Translation: AGV39061.1
KC201440 Genomic DNA Translation: AGV39062.1
KC201441 Genomic DNA Translation: AGV39063.1
KC201442 Genomic DNA Translation: AGV39064.1
KC201443 Genomic DNA Translation: AGV39065.1
KC201444 Genomic DNA Translation: AGV39066.1
KC201445 Genomic DNA Translation: AGV39067.1
KC201446 Genomic DNA Translation: AGV39068.1
KC201447 Genomic DNA Translation: AGV39069.1
KC201448 Genomic DNA Translation: AGV39070.1
KC201449 Genomic DNA Translation: AGV39071.1
KC201450 Genomic DNA Translation: AGV39072.1
KC201451 Genomic DNA Translation: AGV39073.1
KC201452 Genomic DNA Translation: AGV39074.1
KC201453 Genomic DNA Translation: AGV39075.1
KC201454 Genomic DNA Translation: AGV39076.1
KC201455 Genomic DNA Translation: AGV39077.1
KC201456 Genomic DNA Translation: AGV39078.1
KC201457 Genomic DNA Translation: AGV39079.1
KC201458 Genomic DNA Translation: AGV39080.1
KC201459 Genomic DNA Translation: AGV39081.1
KC201463 Genomic DNA Translation: AGV39085.1
KC201466 Genomic DNA Translation: AGV39088.1
KC201471 Genomic DNA Translation: AGV39093.1
KC201472 Genomic DNA Translation: AGV39094.1
KC201475 Genomic DNA Translation: AGV39097.1
KC201476 Genomic DNA Translation: AGV39098.1
KC201477 Genomic DNA Translation: AGV39099.1
KC201478 Genomic DNA Translation: AGV39100.1
KC201479 Genomic DNA Translation: AGV39101.1
KC201481 Genomic DNA Translation: AGV39103.1
KC201483 Genomic DNA Translation: AGV39105.1
KC201484 Genomic DNA Translation: AGV39106.1
KC201485 Genomic DNA Translation: AGV39107.1
KC201486 Genomic DNA Translation: AGV39108.1
KC201487 Genomic DNA Translation: AGV39109.1
KC201488 Genomic DNA Translation: AGV39110.1
KC201489 Genomic DNA Translation: AGV39111.1
KC201490 Genomic DNA Translation: AGV39112.1
KC201491 Genomic DNA Translation: AGV39113.1
KC201492 Genomic DNA Translation: AGV39114.1
KC201493 Genomic DNA Translation: AGV39115.1
KC201494 Genomic DNA Translation: AGV39116.1
KC201495 Genomic DNA Translation: AGV39117.1
KC201496 Genomic DNA Translation: AGV39118.1
KC201497 Genomic DNA Translation: AGV39119.1
KC201498 Genomic DNA Translation: AGV39120.1
KC201499 Genomic DNA Translation: AGV39121.1
KC201502 Genomic DNA Translation: AGV39124.1
KC201503 Genomic DNA Translation: AGV39125.1
KC201504 Genomic DNA Translation: AGV39126.1
KC201505 Genomic DNA Translation: AGV39127.1
KC201506 Genomic DNA Translation: AGV39128.1
KC201507 Genomic DNA Translation: AGV39129.1
KC201508 Genomic DNA Translation: AGV39130.1
KC201509 Genomic DNA Translation: AGV39131.1
KC201511 Genomic DNA Translation: AGV39133.1
KC201512 Genomic DNA Translation: AGV39134.1
KC201513 Genomic DNA Translation: AGV39135.1
KC201514 Genomic DNA Translation: AGV39136.1
KC201515 Genomic DNA Translation: AGV39137.1
KC201516 Genomic DNA Translation: AGV39138.1
KC201517 Genomic DNA Translation: AGV39139.1
KC201518 Genomic DNA Translation: AGV39140.1
KC201519 Genomic DNA Translation: AGV39141.1
KC201520 Genomic DNA Translation: AGV39142.1
KC201521 Genomic DNA Translation: AGV39143.1
KC201522 Genomic DNA Translation: AGV39144.1
KC201523 Genomic DNA Translation: AGV39145.1
KC201524 Genomic DNA Translation: AGV39146.1
KC201525 Genomic DNA Translation: AGV39147.1
KC201526 Genomic DNA Translation: AGV39148.1
KC201527 Genomic DNA Translation: AGV39149.1
KC201528 Genomic DNA Translation: AGV39150.1
KC201529 Genomic DNA Translation: AGV39151.1
KC201530 Genomic DNA Translation: AGV39152.1
KC201531 Genomic DNA Translation: AGV39153.1
KC201532 Genomic DNA Translation: AGV39154.1
KC201533 Genomic DNA Translation: AGV39155.1
KC201534 Genomic DNA Translation: AGV39156.1
KC201535 Genomic DNA Translation: AGV39157.1
KC201536 Genomic DNA Translation: AGV39158.1
KC201537 Genomic DNA Translation: AGV39159.1
KC201538 Genomic DNA Translation: AGV39160.1
KC201539 Genomic DNA Translation: AGV39161.1
KC201541 Genomic DNA Translation: AGV39163.1
KC201547 Genomic DNA Translation: AGV39169.1
KC201552 Genomic DNA Translation: AGV39174.1
KC201555 Genomic DNA Translation: AGV39177.1
KC201556 Genomic DNA Translation: AGV39178.1
KC201557 Genomic DNA Translation: AGV39179.1
KC201558 Genomic DNA Translation: AGV39180.1
KC201559 Genomic DNA Translation: AGV39181.1
KC201560 Genomic DNA Translation: AGV39182.1
KC201561 Genomic DNA Translation: AGV39183.1
KC201562 Genomic DNA Translation: AGV39184.1
KC201563 Genomic DNA Translation: AGV39185.1
KC201564 Genomic DNA Translation: AGV39186.1
KC201565 Genomic DNA Translation: AGV39187.1
KC201567 Genomic DNA Translation: AGV39189.1
KC201568 Genomic DNA Translation: AGV39190.1
KC201569 Genomic DNA Translation: AGV39191.1
KC201571 Genomic DNA Translation: AGV39193.1
KC201573 Genomic DNA Translation: AGV39195.1
KC201574 Genomic DNA Translation: AGV39196.1
KC201575 Genomic DNA Translation: AGV39197.1
KC201576 Genomic DNA Translation: AGV39198.1
KC201577 Genomic DNA Translation: AGV39199.1
KC201578 Genomic DNA Translation: AGV39200.1
KC201579 Genomic DNA Translation: AGV39201.1
KC201580 Genomic DNA Translation: AGV39202.1
KC201581 Genomic DNA Translation: AGV39203.1
KC201582 Genomic DNA Translation: AGV39204.1
KC201583 Genomic DNA Translation: AGV39205.1
KC201584 Genomic DNA Translation: AGV39206.1
KC201585 Genomic DNA Translation: AGV39207.1
KC201586 Genomic DNA Translation: AGV39208.1
KC201587 Genomic DNA Translation: AGV39209.1
KC201588 Genomic DNA Translation: AGV39210.1
AB775900 mRNA Translation: BAM75357.1
CH471185 Genomic DNA Translation: EAW59356.1

NCBI Reference Sequences

More...
RefSeqi
NP_000363.1, NM_000372.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7299

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7299

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KC201429 Genomic DNA Translation: AGV39051.1
KC201430 Genomic DNA Translation: AGV39052.1
KC201431 Genomic DNA Translation: AGV39053.1
KC201433 Genomic DNA Translation: AGV39055.1
KC201434 Genomic DNA Translation: AGV39056.1
KC201435 Genomic DNA Translation: AGV39057.1
KC201436 Genomic DNA Translation: AGV39058.1
KC201437 Genomic DNA Translation: AGV39059.1
KC201438 Genomic DNA Translation: AGV39060.1
KC201439 Genomic DNA Translation: AGV39061.1
KC201440 Genomic DNA Translation: AGV39062.1
KC201441 Genomic DNA Translation: AGV39063.1
KC201442 Genomic DNA Translation: AGV39064.1
KC201443 Genomic DNA Translation: AGV39065.1
KC201444 Genomic DNA Translation: AGV39066.1
KC201445 Genomic DNA Translation: AGV39067.1
KC201446 Genomic DNA Translation: AGV39068.1
KC201447 Genomic DNA Translation: AGV39069.1
KC201448 Genomic DNA Translation: AGV39070.1
KC201449 Genomic DNA Translation: AGV39071.1
KC201450 Genomic DNA Translation: AGV39072.1
KC201451 Genomic DNA Translation: AGV39073.1
KC201452 Genomic DNA Translation: AGV39074.1
KC201453 Genomic DNA Translation: AGV39075.1
KC201454 Genomic DNA Translation: AGV39076.1
KC201455 Genomic DNA Translation: AGV39077.1
KC201456 Genomic DNA Translation: AGV39078.1
KC201457 Genomic DNA Translation: AGV39079.1
KC201458 Genomic DNA Translation: AGV39080.1
KC201459 Genomic DNA Translation: AGV39081.1
KC201463 Genomic DNA Translation: AGV39085.1
KC201466 Genomic DNA Translation: AGV39088.1
KC201471 Genomic DNA Translation: AGV39093.1
KC201472 Genomic DNA Translation: AGV39094.1
KC201475 Genomic DNA Translation: AGV39097.1
KC201476 Genomic DNA Translation: AGV39098.1
KC201477 Genomic DNA Translation: AGV39099.1
KC201478 Genomic DNA Translation: AGV39100.1
KC201479 Genomic DNA Translation: AGV39101.1
KC201481 Genomic DNA Translation: AGV39103.1
KC201483 Genomic DNA Translation: AGV39105.1
KC201484 Genomic DNA Translation: AGV39106.1
KC201485 Genomic DNA Translation: AGV39107.1
KC201486 Genomic DNA Translation: AGV39108.1
KC201487 Genomic DNA Translation: AGV39109.1
KC201488 Genomic DNA Translation: AGV39110.1
KC201489 Genomic DNA Translation: AGV39111.1
KC201490 Genomic DNA Translation: AGV39112.1
KC201491 Genomic DNA Translation: AGV39113.1
KC201492 Genomic DNA Translation: AGV39114.1
KC201493 Genomic DNA Translation: AGV39115.1
KC201494 Genomic DNA Translation: AGV39116.1
KC201495 Genomic DNA Translation: AGV39117.1
KC201496 Genomic DNA Translation: AGV39118.1
KC201497 Genomic DNA Translation: AGV39119.1
KC201498 Genomic DNA Translation: AGV39120.1
KC201499 Genomic DNA Translation: AGV39121.1
KC201502 Genomic DNA Translation: AGV39124.1
KC201503 Genomic DNA Translation: AGV39125.1
KC201504 Genomic DNA Translation: AGV39126.1
KC201505 Genomic DNA Translation: AGV39127.1
KC201506 Genomic DNA Translation: AGV39128.1
KC201507 Genomic DNA Translation: AGV39129.1
KC201508 Genomic DNA Translation: AGV39130.1
KC201509 Genomic DNA Translation: AGV39131.1
KC201511 Genomic DNA Translation: AGV39133.1
KC201512 Genomic DNA Translation: AGV39134.1
KC201513 Genomic DNA Translation: AGV39135.1
KC201514 Genomic DNA Translation: AGV39136.1
KC201515 Genomic DNA Translation: AGV39137.1
KC201516 Genomic DNA Translation: AGV39138.1
KC201517 Genomic DNA Translation: AGV39139.1
KC201518 Genomic DNA Translation: AGV39140.1
KC201519 Genomic DNA Translation: AGV39141.1
KC201520 Genomic DNA Translation: AGV39142.1
KC201521 Genomic DNA Translation: AGV39143.1
KC201522 Genomic DNA Translation: AGV39144.1
KC201523 Genomic DNA Translation: AGV39145.1
KC201524 Genomic DNA Translation: AGV39146.1
KC201525 Genomic DNA Translation: AGV39147.1
KC201526 Genomic DNA Translation: AGV39148.1
KC201527 Genomic DNA Translation: AGV39149.1
KC201528 Genomic DNA Translation: AGV39150.1
KC201529 Genomic DNA Translation: AGV39151.1
KC201530 Genomic DNA Translation: AGV39152.1
KC201531 Genomic DNA Translation: AGV39153.1
KC201532 Genomic DNA Translation: AGV39154.1
KC201533 Genomic DNA Translation: AGV39155.1
KC201534 Genomic DNA Translation: AGV39156.1
KC201535 Genomic DNA Translation: AGV39157.1
KC201536 Genomic DNA Translation: AGV39158.1
KC201537 Genomic DNA Translation: AGV39159.1
KC201538 Genomic DNA Translation: AGV39160.1
KC201539 Genomic DNA Translation: AGV39161.1
KC201541 Genomic DNA Translation: AGV39163.1
KC201547 Genomic DNA Translation: AGV39169.1
KC201552 Genomic DNA Translation: AGV39174.1
KC201555 Genomic DNA Translation: AGV39177.1
KC201556 Genomic DNA Translation: AGV39178.1
KC201557 Genomic DNA Translation: AGV39179.1
KC201558 Genomic DNA Translation: AGV39180.1
KC201559 Genomic DNA Translation: AGV39181.1
KC201560 Genomic DNA Translation: AGV39182.1
KC201561 Genomic DNA Translation: AGV39183.1
KC201562 Genomic DNA Translation: AGV39184.1
KC201563 Genomic DNA Translation: AGV39185.1
KC201564 Genomic DNA Translation: AGV39186.1
KC201565 Genomic DNA Translation: AGV39187.1
KC201567 Genomic DNA Translation: AGV39189.1
KC201568 Genomic DNA Translation: AGV39190.1
KC201569 Genomic DNA Translation: AGV39191.1
KC201571 Genomic DNA Translation: AGV39193.1
KC201573 Genomic DNA Translation: AGV39195.1
KC201574 Genomic DNA Translation: AGV39196.1
KC201575 Genomic DNA Translation: AGV39197.1
KC201576 Genomic DNA Translation: AGV39198.1
KC201577 Genomic DNA Translation: AGV39199.1
KC201578 Genomic DNA Translation: AGV39200.1
KC201579 Genomic DNA Translation: AGV39201.1
KC201580 Genomic DNA Translation: AGV39202.1
KC201581 Genomic DNA Translation: AGV39203.1
KC201582 Genomic DNA Translation: AGV39204.1
KC201583 Genomic DNA Translation: AGV39205.1
KC201584 Genomic DNA Translation: AGV39206.1
KC201585 Genomic DNA Translation: AGV39207.1
KC201586 Genomic DNA Translation: AGV39208.1
KC201587 Genomic DNA Translation: AGV39209.1
KC201588 Genomic DNA Translation: AGV39210.1
AB775900 mRNA Translation: BAM75357.1
CH471185 Genomic DNA Translation: EAW59356.1
RefSeqiNP_000363.1, NM_000372.4

3D structure databases

SMRiL8B082
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3663 806 antibodies

Genome annotation databases

GeneIDi7299
KEGGihsa:7299

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7299
EuPathDBiHostDB:ENSG00000077498.8

Phylogenomic databases

eggNOGiENOG410IEZU Eukaryota
ENOG410Y42I LUCA
HOGENOMiCLU_038693_1_0_1
KOiK00505
OMAiMNGSMSQ
OrthoDBi881347at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
7299 3 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TYR human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7299

Gene expression databases

BgeeiENSG00000077498 Expressed in pigmented layer of retina and 27 other tissues
ExpressionAtlasiL8B082 baseline and differential

Family and domain databases

Gene3Di1.10.1280.10, 1 hit
InterProiView protein in InterPro
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF00264 Tyrosinase, 1 hit
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 1 hit
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 1 hit
PS00498 TYROSINASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL8B082_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: L8B082
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: June 17, 2020
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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