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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacillus sp. GHH01
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationSAAS annotation (EC:1.4.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotationImported
ORF Names:GHH_c25010Imported
OrganismiGeobacillus sp. GHH01Imported
Taxonomic identifieri1233873 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000011251 Componenti: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00282

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

L8A124-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPKRQGKG KNAVLHRYLP MTEEDKQEML KTIGVASIDD LFADIPEQVR
60 70 80 90 100
FRGELKVKPA KSEPELWKEL AALAEKNASV KQYVSFLGAG VYDHYIPAVV
110 120 130 140 150
DHVLSRSEFY TAYTPYQPEI SQGELQAIFE FQTMVCELTG MDVANSSMYD
160 170 180 190 200
GGTALAEAVL LSAAHTKRKK VLISTAVHPQ YREVVRTYAK GQKLEVKEIP
210 220 230 240 250
YDGGITDLKA LEAEMGDDVA CVVVQYPNFF GQIEPLKAIA PLAHEKKSLF
260 270 280 290 300
VVASNPLALG VLTPPGAFGA DIVVGDMQPF GIPTQFGGPH CGYFAVKAPL
310 320 330 340 350
MRKIPGRLVG QTTDEDGRRG FVLTLQAREQ HIRRDKATSN ICSNQALNAL
360 370 380 390 400
AASVALSALG KRGVKEMAAM NIQKAHYAKV ELEKRGLSSP FAGPFFNEFV
410 420 430 440 450
IRLGRPVSDV NDRLLEKGII GGYDLGADYP ELAGHMLVAV TELRTKEEID
460
RFVNELGDGH A
Length:461
Mass (Da):50,478
Last modified:April 3, 2013 - v1
Checksum:i45FD795B9C49168F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP004008 Genomic DNA Translation: AGE23012.1

Genome annotation databases

EnsemblBacteriaiAGE23012; AGE23012; GHH_c25010
KEGGiggh:GHH_c25010
PATRICifig|1233873.3.peg.2682

Similar proteinsi

Entry informationi

Entry nameiL8A124_9BACI
AccessioniPrimary (citable) accession number: L8A124
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: April 25, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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