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Protein

Probable DNA ligase

Gene

ligB

Organism
Mycobacterium liflandii (strain 128FXT)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei215ATPUniRule annotation1
Active sitei217N6-AMP-lysine intermediateUniRule annotation1
Binding sitei222ATPUniRule annotation1
Binding sitei237ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei306ATPUniRule annotation1
Binding sitei378ATPUniRule annotation1
Binding sitei384ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligBImported
Synonyms:ligUniRule annotation
Ordered Locus Names:MULP_01773Imported
OrganismiMycobacterium liflandii (strain 128FXT)Imported
Taxonomic identifieri459424 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000011157 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 418DNA_LIGASE_A3InterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

L7V5D3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLIDIASTS LNVGGTSSRL AKVARIAELL RAAAPDPELV AIVVAWLSGE
60 70 80 90 100
LRQRQIGVGW ATLRSLPAAA GSPALTVTGT DAAFSEIGAV SGKGSAARRR
110 120 130 140 150
ELITRLFAAS TETEQAFLVR LLSGELRQGA LAGIMVDAVA RAAEVPATAV
160 170 180 190 200
QRAAMLGGDL PTVAAACLAA GSSGTAGALD SFTLRVGRPI GPMLAQSAGS
210 220 230 240 250
ITDALERHGG ATIFEAKLDG ARVQIHRTGD EVTVYTRSLD DVTARLPEVV
260 270 280 290 300
QATLALPVSD LVADGEAIAL QPDGRPHRFQ VTASRFGRSV NVAAAQAKQP
310 320 330 340 350
LSVFFFDILH RDGRDLLDAP TTDRLAALDA VVPARHRVDR LTTADAAAAT
360 370 380 390 400
DFLRATLAAG HEGVMAKSPT APYLAGRRGA GWLKVKPVHT LDLVVLAVEW
410 420 430 440 450
GSGRRRGKLS NIHLGARDAA TGEFVMLGKT FKGMTDAMLD WQTAQFTELA
460 470 480 490 500
VGGTDGYVVA LRPEQVVEVA FDGVQASSRY PGGLALRFAR VVRYRDDKGP
510
ADADTIDTVR ALY
Length:513
Mass (Da):53,790
Last modified:April 3, 2013 - v1
Checksum:i8E2745347A204AE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003899 Genomic DNA Translation: AGC61693.1
RefSeqiWP_015355063.1, NC_020133.1

Genome annotation databases

EnsemblBacteriaiAGC61693; AGC61693; MULP_01773
KEGGimli:MULP_01773
PATRICifig|459424.11.peg.1819

Similar proteinsi

Entry informationi

Entry nameiL7V5D3_MYCL1
AccessioniPrimary (citable) accession number: L7V5D3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 3, 2013
Last sequence update: April 3, 2013
Last modified: March 28, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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