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UniProtKB - L7T0T8 (L7T0T8_DANRE)
Protein
Submitted name:
Monocarboxylate transporter 8
Gene
slc16a2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- thyroid hormone binding Source: ZFIN
- thyroid hormone transmembrane transporter activity Source: ZFIN
GO - Biological processi
- brain development Source: ZFIN
- central nervous system development Source: ZFIN
- chordate embryonic development Source: ZFIN
- locomotion Source: ZFIN
- neuron differentiation Source: ZFIN
- oligodendrocyte differentiation Source: ZFIN
- Schwann cell differentiation Source: ZFIN
- spinal cord development Source: ZFIN
- spinal cord oligodendrocyte cell differentiation Source: ZFIN
- thyroid gland development Source: ZFIN
Protein family/group databases
TCDBi | 2.A.1.13.25, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Submitted name: Monocarboxylate transporter 8Imported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-120117-1, slc16a2 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 121 – 139 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 176 – 199 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 206 – 228 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 240 – 262 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 302 – 324 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 344 – 362 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 374 – 393 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 399 – 423 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 435 – 453 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 465 – 487 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 302 – 526 | MFSInterPro annotationAdd BLAST | 225 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 44 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | Polar residuesSequence analysisAdd BLAST | 22 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR030761, MCT8 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF123, PTHR11360:SF123, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
L7T0T8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSESDDNTA GGTPGSEDPQ AEESSSPAEE FEEQERKLAP EDSTVQLIHT
60 70 80 90 100
GCTDKRPATP PGAHPGQGFV PPEGGFGWVV VFAATWCNGS IFGIQNSFGI
110 120 130 140 150
LHMMLVKHHE KQPDQASQFK VAWVGALAMG MIFFCSPVVS MFTDHFGCRK
160 170 180 190 200
TAVCGAFVAF IGLLTSSFAT TLGLWYFTYG ILFGCGSSFA FQPSLVILGR
210 220 230 240 250
YFRQRLGLAN GVVTAGSSLF SMGLPVLLKK VVEPLGLPRT FQILSIFMLV
260 270 280 290 300
QALLALAFKP LLPSGMCPMP GMALDGGPST PESASRWQKG LAKVRRYFNV
310 320 330 340 350
RVFSILTYRI WAFGVATAVL GYFVPYVHLL NFVKEQFGDT QREWLLLVCI
360 370 380 390 400
GASSGVGRLL FGKIGDLIPG VKKIYMQVAS FILLGVMSMM IPQCAVFEGL
410 420 430 440 450
VVVFVLMGLC DGCFITIMAP IAFELVGPMQ ASQAIGYLLG LMAIPMTAGP
460 470 480 490 500
PIAGLLHDHF GNYHVAFYLA GVPPIVGGIV MFFVPLVHQR MQKRRKETDD
510 520
PSMDKMLKNC SNGDMLPGYT DMETHI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JQ966310 mRNA Translation: AGC26050.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JQ966310 mRNA Translation: AGC26050.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
TCDBi | 2.A.1.13.25, the major facilitator superfamily (mfs) |
Organism-specific databases
ZFINi | ZDB-GENE-120117-1, slc16a2 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR030761, MCT8 IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
PANTHERi | PTHR11360:SF123, PTHR11360:SF123, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | L7T0T8_DANRE | |
Accessioni | L7T0T8Primary (citable) accession number: L7T0T8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | September 29, 2021 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |