UniProtKB - L7RT22 (L7RT22_HUMAN)
Protein
Integrin beta
Gene
ITGB5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- signaling receptor activity Source: InterPro
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- integrin-mediated signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | IntegrinUniRule annotationImportedARBA annotation |
Biological process | Cell adhesionUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Integrin betaUniRule annotation |
Gene namesi | Name:ITGB5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000082781.11 |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Plasma Membrane
- integrin complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 720 – 742 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5014306163 | 25 – 799 | Integrin betaSequence analysisAdd BLAST | 775 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 46 | UniRule annotation | ||
Disulfide bondi | 39 ↔ 75 | UniRule annotation | ||
Disulfide bondi | 49 ↔ 64 | UniRule annotation | ||
Disulfide bondi | 202 ↔ 211 | UniRule annotation | ||
Disulfide bondi | 259 ↔ 300 | UniRule annotation | ||
Disulfide bondi | 401 ↔ 413 | UniRule annotation | ||
Disulfide bondi | 433 ↔ 682 | UniRule annotation | ||
Disulfide bondi | 461 ↔ 465 | UniRule annotation | ||
Disulfide bondi | 484 ↔ 522 | UniRule annotation | ||
Disulfide bondi | 489 ↔ 498 | UniRule annotation | ||
Disulfide bondi | 500 ↔ 513 | UniRule annotation | ||
Disulfide bondi | 528 ↔ 533 | UniRule annotation | ||
Disulfide bondi | 530 ↔ 563 | UniRule annotation | ||
Disulfide bondi | 535 ↔ 548 | UniRule annotation | ||
Disulfide bondi | 550 ↔ 555 | UniRule annotation | ||
Disulfide bondi | 569 ↔ 574 | UniRule annotation | ||
Disulfide bondi | 571 ↔ 602 | UniRule annotation | ||
Disulfide bondi | 576 ↔ 585 | UniRule annotation | ||
Disulfide bondi | 608 ↔ 613 | UniRule annotation | ||
Disulfide bondi | 610 ↔ 657 | UniRule annotation | ||
Disulfide bondi | 615 ↔ 625 | UniRule annotation | ||
Disulfide bondi | 628 ↔ 631 | UniRule annotation | ||
Disulfide bondi | 635 ↔ 644 | UniRule annotation | ||
Disulfide bondi | 641 ↔ 714 | UniRule annotation | ||
Disulfide bondi | 661 ↔ 690 | UniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | L7RT22 |
Expressioni
Gene expression databases
Bgeei | ENSG00000082781, Expressed in stromal cell of endometrium and 244 other tissues |
ExpressionAtlasi | L7RT22, baseline and differential |
Interactioni
Binary interactionsi
Hide detailsL7RT22
Protein-protein interaction databases
IntActi | L7RT22, 6 interactors |
Chemistry databases
BindingDBi | L7RT22 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 76 | PSIInterPro annotationAdd BLAST | 50 | |
Domaini | 35 – 463 | INBInterPro annotationAdd BLAST | 429 | |
Domaini | 137 – 372 | VWFAInterPro annotationAdd BLAST | 236 | |
Domaini | 635 – 719 | Integrin_B_tailInterPro annotationAdd BLAST | 85 | |
Domaini | 743 – 790 | Integrin_b_cytInterPro annotationAdd BLAST | 48 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_011772_0_1_1 |
OMAi | CECNPSH |
OrthoDBi | 473040at2759 |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR040622, I-EGF_1 IPR027067, Integrin_beta-5 IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR014836, Integrin_bsu_cyt_dom IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR032695, Integrin_dom_sf IPR016201, PSI IPR002035, VWF_A IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 1 hit PTHR10082:SF26, PTHR10082:SF26, 1 hit |
Pfami | View protein in Pfam PF18372, I-EGF_1, 1 hit PF08725, Integrin_b_cyt, 1 hit PF07965, Integrin_B_tail, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002512, Integrin_B, 1 hit |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00187, INB, 1 hit SM01241, Integrin_b_cyt, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF69179, SSF69179, 1 hit SSF69687, SSF69687, 1 hit |
i Sequence
Sequence statusi: Complete.
L7RT22-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRAPAPLYA CLLGLCALLP RLAGLNICTS GSATSCEECL LIHPKCAWCS
60 70 80 90 100
KEDFGSPRSI TSRCDLRANL VKNGCGGEIE SPASSFHVLR SLPLSSKGSG
110 120 130 140 150
SAGWDVIQMT PQEIAVNLRP GDKTTFQLQV RQVEDYPVDL YYLMDLSLSM
160 170 180 190 200
KDDLDNIRSL GTKLAEEMRK LTSNFRLGFG SFVDKDISPF SYTAPRYQTN
210 220 230 240 250
PCIGYKLFPN CVPSFGFRHL LPLTDRVDSF NEEVRKQRVS RNRDAPEGGF
260 270 280 290 300
DAVLQAAVCK EKIGWRKDAL HLLVFTTDDV PHIALDGKLG GLVQPHDGQC
310 320 330 340 350
HLNEANEYTA SNQMDYPSLA LLGEKLAENN INLIFAVTKN HYMLYKNFTA
360 370 380 390 400
LIPGTTVEIL DGDSKNIIQL IINAYNSIRS KVELSVWDQP EDLNLFFTAT
410 420 430 440 450
CQDGVSYPGQ RKCEGLKIGD TASFEVSLEA RSCPSRHTEH VFALRPVGFR
460 470 480 490 500
DSLEVGVTYN CTCGCSVGLE PNSARCNGSG TYVCGLCECS PGYLGTRCEC
510 520 530 540 550
QDGENQSVYQ NLCREAEGKP LCSGRGDCSC NQCSCFESEF GKIYGPFCEC
560 570 580 590 600
DNFSCARNKG VLCSGHGECH CGECKCHAGY IGDNCNCSTD ISTCRGRDGQ
610 620 630 640 650
ICSERGHCLC GQCQCTEPGA FGEMCEKCPT CPDACSTKRD CVECLLLHSG
660 670 680 690 700
KPDNQTCHSL CRDEVITWVD TIVKDDQEAV LCFYKTAKDC VMMFTYVELP
710 720 730 740 750
SGKSNLTVLR EPECGNTPNA MTILLAVVGS ILLVGLALLA IWKLLVTIHD
760 770 780 790
RREFAKFQSE RSRARYEMAS NPLYRKPIST HTVDFTFNKF NKSYNGTVD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005630 mRNA Translation: AEE61227.1 JX512446 Genomic DNA Translation: AGC09593.1 |
RefSeqi | NP_002204.2, NM_002213.4 |
Genome annotation databases
GeneIDi | 3693 |
KEGGi | hsa:3693 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005630 mRNA Translation: AEE61227.1 JX512446 Genomic DNA Translation: AGC09593.1 |
RefSeqi | NP_002204.2, NM_002213.4 |
3D structure databases
SMRi | L7RT22 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | L7RT22, 6 interactors |
Chemistry databases
BindingDBi | L7RT22 |
Proteomic databases
PRIDEi | L7RT22 |
Protocols and materials databases
Antibodypediai | 963, 531 antibodies |
DNASUi | 3693 |
Genome annotation databases
GeneIDi | 3693 |
KEGGi | hsa:3693 |
Organism-specific databases
CTDi | 3693 |
VEuPathDBi | HostDB:ENSG00000082781.11 |
Phylogenomic databases
HOGENOMi | CLU_011772_0_1_1 |
OMAi | CECNPSH |
OrthoDBi | 473040at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3693, 191 hits in 1007 CRISPR screens |
ChiTaRSi | ITGB5, human |
GenomeRNAii | 3693 |
Gene expression databases
Bgeei | ENSG00000082781, Expressed in stromal cell of endometrium and 244 other tissues |
ExpressionAtlasi | L7RT22, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR040622, I-EGF_1 IPR027067, Integrin_beta-5 IPR033760, Integrin_beta_N IPR015812, Integrin_bsu IPR014836, Integrin_bsu_cyt_dom IPR012896, Integrin_bsu_tail IPR036349, Integrin_bsu_tail_dom_sf IPR002369, Integrin_bsu_VWA IPR032695, Integrin_dom_sf IPR016201, PSI IPR002035, VWF_A IPR036465, vWFA_dom_sf |
PANTHERi | PTHR10082, PTHR10082, 1 hit PTHR10082:SF26, PTHR10082:SF26, 1 hit |
Pfami | View protein in Pfam PF18372, I-EGF_1, 1 hit PF08725, Integrin_b_cyt, 1 hit PF07965, Integrin_B_tail, 1 hit PF00362, Integrin_beta, 1 hit PF17205, PSI_integrin, 1 hit |
PIRSFi | PIRSF002512, Integrin_B, 1 hit |
PRINTSi | PR01186, INTEGRINB |
SMARTi | View protein in SMART SM00187, INB, 1 hit SM01241, Integrin_b_cyt, 1 hit SM01242, Integrin_B_tail, 1 hit SM00423, PSI, 1 hit SM00327, VWA, 1 hit |
SUPFAMi | SSF53300, SSF53300, 1 hit SSF69179, SSF69179, 1 hit SSF69687, SSF69687, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | L7RT22_HUMAN | |
Accessioni | L7RT22Primary (citable) accession number: L7RT22 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 3, 2013 |
Last sequence update: | April 3, 2013 | |
Last modified: | April 7, 2021 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |