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UniProtKB - L7MZT2 (L7MZT2_ANOCA)
Protein
Tyrosine-protein kinase receptor
Gene
LOC100557787
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
Catalytic activityi
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]UniRule annotationARBA annotationEC:2.7.10.1UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- neurotrophin binding Source: GO_Central
- neurotrophin receptor activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- cellular response to nerve growth factor stimulus Source: GO_Central
- positive regulation of kinase activity Source: GO_Central
- positive regulation of MAPK cascade Source: GO_Central
- positive regulation of neuron projection development Source: GO_Central
- positive regulation of phosphatidylinositol 3-kinase signaling Source: GO_Central
- regulation of protein kinase B signaling Source: GO_Central
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, ReceptorUniRule annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:LOC100557787Imported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- axon Source: GO_Central
- receptor complex Source: GO_Central
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSACAG00000008732, Expressed in testis and 9 other tissues |
Interactioni
GO - Molecular functioni
- neurotrophin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008528 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 310 | Protein kinaseInterPro annotationAdd BLAST | 302 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation
Keywords - Domaini
TransmembraneUniRule annotationPhylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000155645 |
InParanoidi | L7MZT2 |
OMAi | YMETHAP |
OrthoDBi | 295510at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR002011, Tyr_kinase_rcpt_2_CS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 2 hits |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00239, RECEPTOR_TYR_KIN_II, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
L7MZT2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VQHIKRRDII LKRELGEGAF GKVFLAECYN LSPTKDKMLV AVKALKDPTL
60 70 80 90 100
AARKDFQREA ELLTNLQHDH IVKFYGVCGD GDPLIMVFEY MKHGDLNKFL
110 120 130 140 150
RAHGPDAMIL VDGQPRQAKG ELGLSQMLHI ASQIASGMVY LGSQHFVHRD
160 170 180 190 200
LATRNCLVGS NLLVKIGDFG MSRDVYSTDY YREVPHPKGY FSTTWQQQRL
210 220 230 240 250
AAMAATTVGG HTMLPIRWMP PESIMYRKFT TESDVWSFGV ILWEIFTYGK
260 270 280 290 300
QPWFQLSNTE VIECITQGRV LERPRVCPKE VYDIMLGCWQ REPQQRLNIK
310 320
DIYKILHALG KATPIYLDIL G
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH9GEA1 | H9GEA1_ANOCA | Tyrosine-protein kinase receptor | LOC100557787 | 296 | Annotation score: |
Sequence databases
RefSeqi | XP_008120263.1, XM_008122056.1 |
Genome annotation databases
Ensembli | ENSACAT00000008711; ENSACAP00000008528; ENSACAG00000008732 |
GeneIDi | 100557787 |
KEGGi | acs:100557787 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_008120263.1, XM_008122056.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000008528 |
Genome annotation databases
Ensembli | ENSACAT00000008711; ENSACAP00000008528; ENSACAG00000008732 |
GeneIDi | 100557787 |
KEGGi | acs:100557787 |
Phylogenomic databases
eggNOGi | KOG1026, Eukaryota |
GeneTreei | ENSGT00940000155645 |
InParanoidi | L7MZT2 |
OMAi | YMETHAP |
OrthoDBi | 295510at2759 |
Gene expression databases
Bgeei | ENSACAG00000008732, Expressed in testis and 9 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR002011, Tyr_kinase_rcpt_2_CS |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 2 hits |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00219, TyrKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00239, RECEPTOR_TYR_KIN_II, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | L7MZT2_ANOCA | |
Accessioni | L7MZT2Primary (citable) accession number: L7MZT2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 6, 2013 |
Last sequence update: | March 6, 2013 | |
Last modified: | January 19, 2022 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |