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UniProtKB - L5LCR8 (L5LCR8_MYODS)

Entry version 35 (07 Apr 2021)
Sequence version 1 (06 Mar 2013)
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Protein
Submitted name:

Protein polybromo-1

Gene

MDA_GLEAN10007845

Organism
Myotis davidii (David's myotis)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein polybromo-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:MDA_GLEAN10007845Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMyotis davidii (David's myotis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri225400 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Chiroptera › Microchiroptera › Vespertilionidae › Myotis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010556 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		225400.XP_006771893.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini102 – 172BromoInterPro annotationAdd BLAST71
Domaini238 – 308BromoInterPro annotationAdd BLAST71
Domaini437 – 507BromoInterPro annotationAdd BLAST71
Domaini575 – 645BromoInterPro annotationAdd BLAST71
Domaini713 – 783BromoInterPro annotationAdd BLAST71
Domaini857 – 902BromoInterPro annotationAdd BLAST46
Domaini996 – 1114BAHInterPro annotationAdd BLAST119
Domaini1196 – 1312BAHInterPro annotationAdd BLAST117
Domaini1419 – 1487HMG boxInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 77DisorderedSequence analysisAdd BLAST77
Regioni191 – 215DisorderedSequence analysisAdd BLAST25
Regioni530 – 552DisorderedSequence analysisAdd BLAST23
Regioni661 – 689DisorderedSequence analysisAdd BLAST29
Regioni944 – 981DisorderedSequence analysisAdd BLAST38
Regioni1146 – 1171DisorderedSequence analysisAdd BLAST26
Regioni1362 – 1416DisorderedSequence analysisAdd BLAST55
Regioni1471 – 1517DisorderedSequence analysisAdd BLAST47
Regioni1534 – 1639DisorderedSequence analysisAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 34PolarSequence analysisAdd BLAST34
Compositional biasi43 – 59PolarSequence analysisAdd BLAST17
Compositional biasi661 – 676PolyampholyteSequence analysisAdd BLAST16
Compositional biasi944 – 973PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1553 – 1575Pro-richSequence analysisAdd BLAST23
Compositional biasi1609 – 1636Pro-richSequence analysisAdd BLAST28

Keywords - Domaini

BromodomainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1827, Eukaryota

Family and domain databases

Conserved Domains Database

More...CDDi		cd05515, Bromo_polybromo_V, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.920.10, 6 hits
2.30.30.490, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037968, PBRM1_BD5
IPR037382, Rsc/polybromo

The PANTHER Classification System

More...PANTHERi		PTHR16062, PTHR16062, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01426, BAH, 2 hits
PF00439, Bromodomain, 6 hits
PF00505, HMG_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00439, BAH, 2 hits
SM00297, BROMO, 6 hits
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47095, SSF47095, 1 hit
SSF47370, SSF47370, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51038, BAH, 2 hits
PS00633, BROMODOMAIN_1, 5 hits
PS50014, BROMODOMAIN_2, 6 hits
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

L5LCR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVINEGTTLP EGQKTEHEAQ GWIEQTQHSL SDPKKLDSMG SKRRRATSPS 
        60         70         80         90        100
SSVSGDFDDG HHSVSTPGPS RKRRRLSNLP TVDPIAVCHE LYNTIRDYKD 
       110        120        130        140        150
EQGRLLCELF IRAPKRRNQP DYYEVVSQPI DLMKIQQKLK MEEYDDVNLL 
       160        170        180        190        200
TADFQLLFNN AKAYYKPDSP EYKAACKLWD LYLRTRNEFV QKGEADDEDD 
       210        220        230        240        250
DEDGQDNQGT VTEGSSPSYL KEILEQLLEA IVVATNPSGH LISELFQKLP 
       260        270        280        290        300
SKVQYPDYYA IIKEPIDLKT IAQRIQNGSY KSIHAMAKDI DLLAKNAKTY 
       310        320        330        340        350
NEPGSQVFKD ANSIKKIFYM KKAEIEHEMT KSSLRVRTSS NLAAARLTGS 
       360        370        380        390        400
AHSKGSLVEE RNPTSKYYRN KRAVQGGRLS AITMALQYGS ESEEDAALAA 
       410        420        430        440        450
ARYEEGESEA ESITSFMDVS NPFYQLYDTV RSCRNNQGQL IAEPFFHLPS 
       460        470        480        490        500
KKKYPDYYQQ IKMPISLQQI RTKLKNQEYE TLDHLECDLN LMFENAKRYN 
       510        520        530        540        550
VPNSAIYKRV LKLQQVMQAK KKELARRDDI EDGDSMISSA TSDTGSAKRK 
       560        570        580        590        600
SKKNIRKQRM KILFNVVLEA REPGSGRRLC DLFMVKPSKK DYPDYYKIIL 
       610        620        630        640        650
EPMDLKIIEH NIRNDKYAGE EGMMEDMKLM FRNARHYNEE GSQVYNDAHI 
       660        670        680        690        700
LEKLLKDKRK ELGPLPDDDD MASPKLKLSR KSGVSPKKSK YMTPMQQKLN 
       710        720        730        740        750
EVYEAVKNYT DKRGRRLSAI FLRLPSRSEL PDYYLTIKKP MDMEKIRSHM 
       760        770        780        790        800
MANKYQDIDS MVEDFVMMFN NACTYNEPES LIYKDALVLH KVLLETRRDL 
       810        820        830        840        850
EGDEDSHVPN VTLLIQELIH NLFVSVMSHQ DDEGXXXXXX XXXXXXXXAV 
       860        870        880        890        900
DPSFPNKPPL TFDIIRKNVE NNRYRRLDLF QEHMFEVLER ARRMNRTDSE 
       910        920        930        940        950
IYEDAVELQQ FFIKIRDELC KNGEILLSPA LSYTTKHLHN DVEKEKKEKL 
       960        970        980        990       1000
PKEIEEDKLK REEEKREAEK SEDSSGAAGL SGLHRTYSQD CSFKNSMYHV 
      1010       1020       1030       1040       1050
GDYVYVEPSE ASLQPHIVCI ERLWEDSAGE KWLYGCWFYR PNETFHLATR 
      1060       1070       1080       1090       1100
KFLEKEVFKS DYYNKVPVSK ILGKCVVMFV KEYFKLCPEN FRDEDVFVCE 
      1110       1120       1130       1140       1150
SRYSAKTKSF KKIKLWTMPI SSVKFVPRDV PLPVVRVASV FANADKGDDE 
      1160       1170       1180       1190       1200
KNADNSEDSR TEDNFNLEKE KEDVPVEMSN GEPGCHYFEQ LHYNDMWLKV 
      1210       1220       1230       1240       1250
GDCVFIKSHG LVRPRVGRIE KVWVRDGAAY FYGPIFIHPE ETEHEPTKMF 
      1260       1270       1280       1290       1300
YKKEVFLSNL EETCPMTCIL GKCAVLSFKD FLSCRPTEIP ENDVLLCESR 
      1310       1320       1330       1340       1350
YNESDKQMKK FKGLKRFSLS AKVVDDEIYY FRKPIVPQKE PSPLLEKKIQ 
      1360       1370       1380       1390       1400
LLEAKFAELE GGDDDIEEMG EEDSEVIEPP SLPQLQTPLA SELDLMPYTP 
      1410       1420       1430       1440       1450
PQSTPKSAKG SAKKENSKRK INMSGYILFS SEMRAVIKAQ HPDYSFGELS 
      1460       1470       1480       1490       1500
RLVGTEWRNL ETAKKAEYEE RAAKVAEQQE RERAAQQQQP SASPRAGTPV 
      1510       1520       1530       1540       1550
GALMGVVPPP TPMGMLNQQL TPVAGMMGGY PPGLPPLQGP VDGLVSMGSM 
      1560       1570       1580       1590       1600
QPLHPGGPPP HHLPPGVPGL PGIPPPGVMN QGVAPMVGTP AQGGSPYGQQ 
      1610       1620       1630       1640       1650
VGVLGPQGQQ APPPYPGPHP AGPPVIQQPT TPMFVAPPPK TQRLLHSEAY 
      1660       1670       1680       1690       1700
LKYIEGLSAE SNSISKWDQT LAARRRDVHL SKEQESRLPS HWLKSKGAHT 
      1710       1720 
TMADALWRLR DLMLRDTLNI RQAYNLENL
Length:1,729
Mass (Da):197,363
Last modified:March 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i383007C247957806
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KB113051 Genomic DNA Translation: ELK24129.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB113051 Genomic DNA Translation: ELK24129.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

Protein-protein interaction databases

STRINGi225400.XP_006771893.1

Phylogenomic databases

eggNOGiKOG1827, Eukaryota

Family and domain databases

CDDicd05515, Bromo_polybromo_V, 1 hit
Gene3Di1.20.920.10, 6 hits
2.30.30.490, 2 hits
InterProiView protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037968, PBRM1_BD5
IPR037382, Rsc/polybromo
PANTHERiPTHR16062, PTHR16062, 2 hits
PfamiView protein in Pfam
PF01426, BAH, 2 hits
PF00439, Bromodomain, 6 hits
PF00505, HMG_box, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00439, BAH, 2 hits
SM00297, BROMO, 6 hits
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
SSF47370, SSF47370, 6 hits
PROSITEiView protein in PROSITE
PS51038, BAH, 2 hits
PS00633, BROMODOMAIN_1, 5 hits
PS50014, BROMODOMAIN_2, 6 hits
PS50118, HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL5LCR8_MYODS
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: L5LCR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: April 7, 2021
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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