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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

METTL1

Organism
Pteropus alecto (Black flying fox)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotationSAAS annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei78S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei154S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Active sitei157UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotationSAAS annotationImported, RNA-binding, Transferase, tRNA-bindingUniRule annotationSAAS annotation
Biological processtRNA processingUniRule annotationSAAS annotation
LigandS-adenosyl-L-methionineUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
Methyltransferase-like protein 1UniRule annotation
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:METTL1UniRule annotation
ORF Names:PAL_GLEAN10004884Imported
OrganismiPteropus alecto (Black flying fox)Imported
Taxonomic identifieri9402 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMegachiropteraPteropodidaePteropodinaePteropus
Proteomesi
  • UP000010552 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Phosphoserine; by PKB and RPS6KA3UniRule annotation1

Post-translational modificationi

Phosphorylation at Ser-24 inactivates its catalytic activity but does not affect the interaction with WDR4.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Forms a complex with WDR4.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni101 – 102S-adenosyl-L-methionine bindingUniRule annotation2
Regioni134 – 135S-adenosyl-L-methionine bindingUniRule annotation2
Regioni232 – 234S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotationSAAS annotation

Phylogenomic databases

InParanoidiL5KV82

Family and domain databases

HAMAPiMF_03055 tRNA_methyltr_TrmB_euk, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025763 Trm8_euk
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
PTHR23417:SF16 PTHR23417:SF16, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

L5KV82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAPAGAEA PQPQKRYYRQ RAHSNPMADH TLRYPVKPEE MDWSELYPEF
60 70 80 90 100
FAQNQSHDDP KDKKEKRAQA QVEFADIGCG YGGLLVELSP LFPDTLILGL
110 120 130 140 150
EIRVKVSDYV QDRIRALRAA PGGGFQNIAC LRSNAMKHLP NFFRKGQLTK
160 170 180 190 200
MFFLFPDPHF KRTKHKWRII SPTLLAEYAY VLRVGGLVYT ITDVLELHNW
210 220 230 240 250
MCTHFEGHPL FERVPLEELS EDPIVGHLGT STEEGKKVLR NGGKNFPAIF
260 270
RRIQDPALQA MTPNPSPPGH
Length:270
Mass (Da):30,659
Last modified:March 6, 2013 - v1
Checksum:i2AEE4CF6CDD21120
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB030539 Genomic DNA Translation: ELK15332.1
RefSeqiXP_006909035.1, XM_006908973.2

Genome annotation databases

GeneIDi102894980

Similar proteinsi

Entry informationi

Entry nameiL5KV82_PTEAL
AccessioniPrimary (citable) accession number: L5KV82
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: January 31, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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