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Protein

E3 ubiquitin protein ligase

Gene

PAL_GLEAN10011909

Organism
Pteropus alecto (Black flying fox)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotation, LigaseImported, TransferaseUniRule annotation
Biological processUbl conjugation pathwayUniRule annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin protein ligaseUniRule annotation (EC:2.3.2.27UniRule annotation)
Gene namesi
ORF Names:PAL_GLEAN10011909Imported
OrganismiPteropus alecto (Black flying fox)Imported
Taxonomic identifieri9402 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMegachiropteraPteropodidaePteropodinaePteropus
Proteomesi
  • UP000010552 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Subunit structurei

Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini948 – 987RING-typeInterPro annotationAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili63 – 83Sequence analysisAdd BLAST21
Coiled coili230 – 306Sequence analysisAdd BLAST77
Coiled coili329 – 373Sequence analysisAdd BLAST45
Coiled coili438 – 465Sequence analysisAdd BLAST28
Coiled coili487 – 521Sequence analysisAdd BLAST35
Coiled coili627 – 672Sequence analysisAdd BLAST46
Coiled coili686 – 720Sequence analysisAdd BLAST35
Coiled coili723 – 757Sequence analysisAdd BLAST35
Coiled coili765 – 785Sequence analysisAdd BLAST21
Coiled coili800 – 820Sequence analysisAdd BLAST21
Coiled coili828 – 848Sequence analysisAdd BLAST21
Coiled coili898 – 925Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the BRE1 family.UniRule annotation

Keywords - Domaini

Coiled coilUniRule annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

InParanoidiL5KKB7
KOiK10696

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013956 E3_ubiquit_lig_Bre1
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23163 PTHR23163, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

L5KKB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGPGNKRTA GDGGSGPPEK KLSREEKTTT TLIEPIRLGG ISSTEEMDLK
60 70 80 90 100
VLQFKNKKLA ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ
110 120 130 140 150
LDETVEALLR HHENQGELSS GTEVPGIQEG PTRDETPLSE PGTSELRETL
160 170 180 190 200
PMKLRPPLSE PALAFVVALG ASSSEEVELQ LQDRMEFSKA AVSRVVEASD
210 220 230 240 250
RLQRRVEELC QRVYSRGDSD PPGEVARART RELGRENRRL QDLATQLQEK
260 270 280 290 300
HHRISLEYSE LQDKVTSAET KVLEMETTVE DLQWDIEKLR KREQKLNKHL
310 320 330 340 350
AEALEQLNSG YYVSGSSSGF QGGQITLSMQ KFEMLNAELE ENQELANSRM
360 370 380 390 400
AELEKLQAEL QGAVRTNERL KVALRSLPEE VVRETGEYRM LQAQFSLLYN
410 420 430 440 450
ESLQVKTQLD EARGLLLATK NSHLRHIEHM ESDELGLQKK LRTEVIQLED
460 470 480 490 500
TLAQVRKEYE MLRIEFEQNL AANEQAGPIN REMRHLISSL QNHNHQLKGD
510 520 530 540 550
AQRYKRKLRE VQAEIGKLRA QASGSTHSIP NLGHPDDSGL SAPAPGKEEG
560 570 580 590 600
GPGPVIVPDG RKEMASVPSA IITTSSVKKE ELVPSEEDAQ ALTPGSQGPS
610 620 630 640 650
SRGREPEARP KRELREREGP ALGPPPIASA LSRADREKAK VEEAKRKESE
660 670 680 690 700
LLKGLRAELK KAQESQKEMK LLLDMYKSAP KEQRDKVQLM AAERKAKAEV
710 720 730 740 750
DELRSRIRDL EERDRRESKK IADEDALRRI RQAEEQIEHL QRKLGATKQE
760 770 780 790 800
EEALLSEMDV TGQAFEDMQE QNGRLLQQLR EKDDANFKLM SERIKANQIH
810 820 830 840 850
KLLREEKDEL GEQVLGLKSQ VDAQLLTVQK LEEKERALQG SLGGVEKELT
860 870 880 890 900
LRSQALELNK RKAVEAAQLA EDLKVQLEHV QTRLREIQPC LAESRAAREK
910 920 930 940 950
ESFNLKRAQE DISRLRRKLE KQRKVEVYAD ADEILQEEIK EYKARLTCPC
960 970 980 990 1000
CNTRKKDAVL TKCFHVFCFE CVRGRYEARQ RKCPKCNSAF GAHDFHRVYI

S
Length:1,001
Mass (Da):113,908
Last modified:March 6, 2013 - v1
Checksum:i26D48356E2651733
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB030715 Genomic DNA Translation: ELK10973.1
RefSeqiXP_006914203.1, XM_006914141.2

Genome annotation databases

GeneIDi102883063
KEGGipale:102883063

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB030715 Genomic DNA Translation: ELK10973.1
RefSeqiXP_006914203.1, XM_006914141.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102883063
KEGGipale:102883063

Organism-specific databases

CTDi9810

Phylogenomic databases

InParanoidiL5KKB7
KOiK10696

Enzyme and pathway databases

UniPathwayi
UPA00143

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR013956 E3_ubiquit_lig_Bre1
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR23163 PTHR23163, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiL5KKB7_PTEAL
AccessioniPrimary (citable) accession number: L5KKB7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: November 7, 2018
This is version 27 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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