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UniProtKB - L5KEH9 (L5KEH9_PTEAL)

Entry version 35 (10 Feb 2021)
Sequence version 1 (06 Mar 2013)
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Protein
Submitted name:

Retinoblastoma-associated protein

Gene

PAL_GLEAN10021709

Organism
Pteropus alecto (Black flying fox)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressorARBA annotation
Biological processCell cycleARBA annotation, Transcription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Retinoblastoma-associated proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PAL_GLEAN10021709Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPteropus alecto (Black flying fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9402 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Chiroptera › Megachiroptera › Pteropodidae › Pteropodinae › Pteropus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010552 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9402.XP_006916505.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 226DUF3452InterPro annotationAdd BLAST127
Domaini370 – 570RB_AInterPro annotationAdd BLAST201
Domaini657 – 758CYCLINInterPro annotationAdd BLAST102
Domaini765 – 924Rb_CInterPro annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41
Regioni857 – 925DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 29Pro-richSequence analysisAdd BLAST15
Compositional biasi868 – 890PolyampholyteSequence analysisAdd BLAST23
Compositional biasi896 – 916PolarSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the retinoblastoma protein (RB) family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1010, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		L5KEH9

Database of Orthologous Groups

More...OrthoDBi		113612at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR002720, RB_A
IPR002719, RB_B
IPR015030, RB_C
IPR028309, RB_fam
IPR024599, RB_N

The PANTHER Classification System

More...PANTHERi		PTHR13742, PTHR13742, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11934, DUF3452, 1 hit
PF01858, RB_A, 1 hit
PF01857, RB_B, 1 hit
PF08934, Rb_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00385, CYCLIN, 1 hit
SM01367, DUF3452, 1 hit
SM01368, RB_A, 1 hit
SM01369, Rb_C, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47954, SSF47954, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

L5KEH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPKAPRRVA TASAAAPPAP PPPPPTEEDP EQDSGPEDLP LARLEFEETE 
        60         70         80         90        100
EPDFTALCQK LKIPDHVRER AWLTWEKVSS VDGVLESYIQ KKKELWGICI 
       110        120        130        140        150
FIAAVDLDEM PFTFTELQKN IETSVYKFFD LLKEIDTSTK VDNAMSRLLK 
       160        170        180        190        200
KYNVLCALYS KLERTCELIY LTQPSSLIST EINSMLVLKV SWITFLLAKG 
       210        220        230        240        250
EVLQMEDDLV ISFQLMLCVL DYFIKLSPPA LLKEPYKTAV IPINGSPRTP 
       260        270        280        290        300
RRGQNRSARI AKQLENDTRI IEVLCKEHEC NIDEVKNVYF KNFIPFMNSL 
       310        320        330        340        350
GIVASNGLPE VENLSKQYEE IYFKNKDLDA RLFLDHDKTL QADPTDSFEM 
       360        370        380        390        400
QRTPQKSNPD EELSVILQQT PVRTVMNTIQ QLMMILNSAS DQPSDNLISY 
       410        420        430        440        450
FNNCTVNPKE SILKRVKDIG YIFKEKFAKA VGQGCIEIGS QRYKLGVRLY 
       460        470        480        490        500
YRVMESMLKS EEERLSIQNF SKLLNDNTFH MSLLACALEV VMATYSRSTS 
       510        520        530        540        550
QNLDTGTDLS FPWILNVFNL KAFDFYKVIE SFIKAEANLT RDMIKHLERC 
       560        570        580        590        600
EHRIMESLAW LSNSPLFDLI KQVKDREGPA DHLESACTLN LSLQNNHTAA 
       610        620        630        640        650
DMYLSPVRSP KKKGSTTRVN STANAEAQAT SAFQTQKPLK STSLSLFYKK 
       660        670        680        690        700
VYRLAYLRLN TLCARLLSDH PELEHIIWTL FQHTLQNEYE LMRDRHLDQI 
       710        720        730        740        750
MMCSMYGICK VKNIDLKFKI IVTAYKDLPH AVQETFKRVL IREEEYDSII 
       760        770        780        790        800
VFYNSVFMQR LKTNILQYAS TRPPTLSPIP HIPRSPYKFS SSPLRIPGGN 
       810        820        830        840        850
IYISPLKNPY KISEGLPTPT KMTPRSRILV SIGESFGTSE KFQKINQMVC 
       860        870        880        890        900
NSDRVLKRSA EGSNPPKPLK KLRFDIEGPD EADGSKHLPG DSKFQQKLAE 
       910        920 
MTSTRTRMQK QKMNESMNIS NREEK
Length:925
Mass (Da):105,958
Last modified:March 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70CD5CCC07AA029D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KB030862 Genomic DNA Translation: ELK08878.1

NCBI Reference Sequences

More...RefSeqi		XP_006916505.1, XM_006916443.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102893019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pale:102893019

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB030862 Genomic DNA Translation: ELK08878.1
RefSeqiXP_006916505.1, XM_006916443.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9402.XP_006916505.1

Genome annotation databases

GeneIDi102893019
KEGGipale:102893019

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5925

Phylogenomic databases

eggNOGiKOG1010, Eukaryota
InParanoidiL5KEH9
OrthoDBi113612at2759

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR002720, RB_A
IPR002719, RB_B
IPR015030, RB_C
IPR028309, RB_fam
IPR024599, RB_N
PANTHERiPTHR13742, PTHR13742, 1 hit
PfamiView protein in Pfam
PF11934, DUF3452, 1 hit
PF01858, RB_A, 1 hit
PF01857, RB_B, 1 hit
PF08934, Rb_C, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SM01367, DUF3452, 1 hit
SM01368, RB_A, 1 hit
SM01369, Rb_C, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL5KEH9_PTEAL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: L5KEH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: February 10, 2021
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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