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Entry version 35 (19 Jan 2022)
Sequence version 1 (06 Mar 2013)
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Protein
Submitted name:

Sorbin and SH3 domain-containing protein 2

Gene

PAL_GLEAN10021672

Organism
Pteropus alecto (Black flying fox)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sorbin and SH3 domain-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PAL_GLEAN10021672Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPteropus alecto (Black flying fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9402 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMegachiropteraPteropodidaePteropodinaePteropus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010552 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini245 – 306SoHoInterPro annotationAdd BLAST62
Domaini1017 – 1078SH3InterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni314 – 386DisorderedSequence analysisAdd BLAST73
Regioni943 – 1019DisorderedSequence analysisAdd BLAST77
Regioni1081 – 1129DisorderedSequence analysisAdd BLAST49
Regioni1349 – 1375DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi314 – 340Polar residuesSequence analysisAdd BLAST27
Compositional biasi346 – 361Pro residuesSequence analysisAdd BLAST16
Compositional biasi362 – 386Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi953 – 967Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi984 – 1003Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1098 – 1112Polar residuesSequence analysisAdd BLAST15
Compositional biasi1352 – 1375Polar residuesSequence analysisAdd BLAST24

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
L5KAX9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR14167:SF56, PTHR14167:SF56, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018, SH3_1, 1 hit
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 2 hits
SM00459, Sorb, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 1 hit
PS50831, SOHO, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

L5KAX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSNEDDSSQ TIVYSEESNT TVSYTQKITN LLPAASSTSP PADADLTSPF
60 70 80 90 100
LQEDYVQDSQ TQRISTLKLI HNQDVGSSIP FNTPQFPKSV DVPSFPKKTC
110 120 130 140 150
SPPPNPAPEI HTASLSIQIA PPSGHNPESH KQLPELSPET TKIPLQQERQ
160 170 180 190 200
KSAVAAASQS SDCRVSQITV NGNSGGVSPM SYYQRPFSPS AYSLPGSLNS
210 220 230 240 250
SIIMQHGRSL DSTETYPQHA QSLDGTVGSS IPLYRSSEEE KRVTIIKAPH
260 270 280 290 300
YPGIGPVDES GIPTAIRTTV DRPKDWYKTM FKQIHMVHKP DDDTDMYNTP
310 320 330 340 350
YTYNAGLYNS PYSAQSHPAA KTQTYRPLSK SHSDNGTDVI KDASSPVPPP
360 370 380 390 400
HVPPPVPPLR PRDRSSTEKH DWDPPDRKVD TRKFRSEPRS IFEYEPGKSS
410 420 430 440 450
ILQHERPTDR IHPDDIDLEN EPWYKFFSEL EFGRPASLYQ SSIDRSLERP
460 470 480 490 500
TSYSELNSNP SSELDYCNTY RQHLDVPRDS QRAITFKNGW QMARQNAEVW
510 520 530 540 550
SSTEETVSPK IKSRSCDDLL NDDCDSFPDP KTKSESMGSL LCEEVSEEHG
560 570 580 590 600
PMPWASPYIQ EGRSNGRSRL RHRPAHDAPG FLKMYKKMHR INRKDLMNSE
610 620 630 640 650
VICSVKSRIM QYEKEQQHKG LLHGWSQSST EEVPRDMVPT RISEFEKLIQ
660 670 680 690 700
KSKSMPNLGD EMLSPIILEP QQNGLCPKRR FSIESLLEEE NQSRHPCQVQ
710 720 730 740 750
RSYKSKTLVP IHIEVTSDEQ PRAHVEFSDS DQDGVVSDHS DYVHVEGSSF
760 770 780 790 800
CSESDFDHFS FTSSESFYGS SHHHHHHHHH HHRHLISSCK GRCPASYTRF
810 820 830 840 850
TTMLKHERAK HENAEEPRRQ EMDPGLSKLA FLVSPVPFRR KKNSTPKKQT
860 870 880 890 900
EKAKCKTSVF EALDSALKDI CDQIKAEKRR GSLPDNSILH RLISGLLPDI
910 920 930 940 950
PERNSSLKAL KRSPMHQPFH PLPQDGAIHC PLYPSECGRM PHSASFQDMD
960 970 980 990 1000
TNNNYHHQDH ESTLSLQDRE SPRSYSSALT DLGRSAPRER RGTPEKEKLM
1010 1020 1030 1040 1050
PPEKAQPARP PPPAQPGEIG EAIAKYNFNA DTNVELSLRK GDRVILLKRV
1060 1070 1080 1090 1100
DQNWYEGKIP GTNRQGIFPV SYVEVVKRNT SKGAEDYPDP PIPHSYSSDR
1110 1120 1130 1140 1150
IHSLSSNKLA SSERAPPPRH KASPDSDKGA LQGITQEWLS LTAKSPPANP
1160 1170 1180 1190 1200
LTPTPPPFLD NFLDELEKLG ALTLSDDQAK PNILEEITLE IKEESSVLLP
1210 1220 1230 1240 1250
LPPASVPAKS PSFQPPFLCS GVTSTTVQPS EAMPLQDPRK TTQNKCADVT
1260 1270 1280 1290 1300
KMRKVFAGLE KIPEVLGDKF VASGHTDVGP LPQTLPIIGE EDEDICEGVT
1310 1320 1330 1340 1350
SGIQRGPESQ EPDALWFGHD GTEVTPSLHI EEEEEERKPD CLEYAVTTSA
1360 1370 1380 1390 1400
GPRTPKEDSN AAKTINETNL DPQNGRLMYQ NREDGTILFQ ALYNYTPRNE
1410 1420 1430 1440 1450
DELELRESDV IDVMEKCDDG WNLKKNQILW YFSRKLCQEA VNHSPSYLCC
1460 1470
KRQGMTAGGL REPFRQVMLQ LPLLRLL
Length:1,477
Mass (Da):166,070
Last modified:March 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD4E10F00678D896
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KB030862 Genomic DNA Translation: ELK08844.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KB030862 Genomic DNA Translation: ELK08844.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

InParanoidiL5KAX9

Family and domain databases

InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type
PANTHERiPTHR14167:SF56, PTHR14167:SF56, 2 hits
PfamiView protein in Pfam
PF00018, SH3_1, 1 hit
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit
SMARTiView protein in SMART
SM00326, SH3, 2 hits
SM00459, Sorb, 1 hit
SUPFAMiSSF50044, SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 1 hit
PS50831, SOHO, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL5KAX9_PTEAL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: L5KAX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: January 19, 2022
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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