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Protein

General transcription factor IIH subunit 4

Gene

TFB2

Organism
Guillardia theta CCMP2712
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
Name:TFB2Imported
ORF Names:GUITHDRAFT_104031Imported
OrganismiGuillardia theta CCMP2712Imported
Taxonomic identifieri905079 [NCBI]
Taxonomic lineageiEukaryotaCryptophytaPyrenomonadalesGeminigeraceaeGuillardia
Proteomesi
  • UP000011087 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 85Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK03144
OMAiYLEQYAH

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 2 hits
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

L1JP30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVVEDMAWE VCRTVGELPE SACSKLYENQ WACVSMMRLM PPLGRQLLMR
60 70 80 90 100
LVHLGQERVE LLRWVDEGEV QRQRLEEVVR KMEEVKILYL DEDVKESDGV
110 120 130 140 150
SVRINPTFSE RILQFLLQRD TSPWSKGRIM GDSPDTTAEE LQQWAQNRWE
160 170 180 190 200
SILHYMVSPG LDPMKRPEPG WKPTKWVRGI LVGEDKNGNS FMMSLQNLAP
210 220 230 240 250
KITAFGFQFL LRPLRNQILQ MLMHVLTKKG SENKDLQDSL SCIFQLSFCT
260 270 280 290 300
LGAGYRLDLL SRSNQELITS LHDLGAVYFK PNDRQYFFPT PLIVNLCTES
310 320 330 340 350
EVPSGPSTDA GVADEFSAEP AAGILRLFTR PIYKFPHMII AVITRESIRN
360 370 380 390 400
ALIIEYLRMH AHPQCLENWP IVPEVVTDQI CFWEQERCRI RAEPAVAYHN
410 420 430 440 450
FFSGEAHRAC EKEARRLKFN DKGPGEVAKR EACLYSDTSE QLLVVPEAAD
460
PLIRKFIETS INE
Length:463
Mass (Da):53,275
Last modified:March 6, 2013 - v1
Checksum:i199C16B01AFC85BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH992979 Genomic DNA Translation: EKX50217.1
RefSeqiXP_005837197.1, XM_005837140.1

Genome annotation databases

EnsemblProtistsiEKX50217; EKX50217; GUITHDRAFT_104031
GeneIDi17306832
KEGGigtt:GUITHDRAFT_104031

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JH992979 Genomic DNA Translation: EKX50217.1
RefSeqiXP_005837197.1, XM_005837140.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEKX50217; EKX50217; GUITHDRAFT_104031
GeneIDi17306832
KEGGigtt:GUITHDRAFT_104031

Phylogenomic databases

KOiK03144
OMAiYLEQYAH

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 2 hits
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiL1JP30_GUITH
AccessioniPrimary (citable) accession number: L1JP30
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: February 28, 2018
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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