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Protein

Kinesin-like protein KIF14

Gene

Kif14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (PubMed:24949858). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (By similarity). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (By similarity). Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (By similarity). During late neurogenesis, regulates the cerebellar and cerebral cortex development and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (PubMed:23308235, PubMed:24931760). Also is required for chromosome congression and alignment during mitotic cell cycle process (By similarity). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (By similarity).By similarity3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=62 µM for ATP1 Publication
  2. KM=33 µM for ATP (in the presence of microtubule)1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi482 – 489ATPPROSITE-ProRule annotationCombined sources8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMotor protein
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-5625900 RHO GTPases activate CIT

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Kinesin-like protein KIF14Curated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Kif141 PublicationImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:1098226 Kif14

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    The lag homozygous mutant mice that lack detectable Kif14 expression are indistinguishable from normal littermates at birth. At P10, mutants exhibit an overt ataxic phenotype that increased in severity over time. At P12, lag homozygous mutant mice are unable to stand for 10 s on a narrow platform. Their gait is wide and uncoordinated, and they frequently fell on their backs while walking. These defects in voluntary movement control, posture and balance are accompanied by progressive weakness and failure to gain body weight. By P14, the homozygous mutants in a litter could be identified by their small size and uncontrolled movements. The homozygous mutants all died by P21. The lag homozygous mutant mice also display a flathead, a reduction in brain size, slender optic nerves, and a translucent spinal cord.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004317061 – 1674Kinesin-like protein KIF14Add BLAST1674

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei257PhosphoserineBy similarity1
    Modified residuei262PhosphothreonineBy similarity1
    Modified residuei973PhosphoserineBy similarity1
    Modified residuei1326PhosphoserineBy similarity1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    L0N7N1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    L0N7N1

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    L0N7N1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    L0N7N1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000041498 Expressed in 28 organ(s), highest expression level in embryonic stem cell

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    L0N7N1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    L0N7N1 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23; targets to the central spindle. Directly interacts with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form); targets to the midbody. Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation (By similarity). Interacts with AKT1; the interaction is detected in the plasma membrane upon INS stimulation and promotes AKT1 phosphorylation. Interacts with SVIL; at midbody during cytokinesis. Interacts with RADIL (via PDZ domain); recruits RADIL to the microtubule network restricting RADIL from interaction with activated RAP1A.By similarity

    GO - Molecular functioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000044257

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    11674
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    L0N7N1

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    L0N7N1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini393 – 736Kinesin motorPROSITE-ProRule annotationAdd BLAST344
    Domaini860 – 911FHAPROSITE-ProRule annotationAdd BLAST52

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 391Required for PRC1-bindingBy similarityAdd BLAST391
    Regioni391 – 772Required for microtubule-binding with high affinity1 PublicationAdd BLAST382
    Regioni936 – 1674Required for CIT-bindingBy similarityAdd BLAST739

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili743 – 826Sequence analysisAdd BLAST84
    Coiled coili961 – 1110Sequence analysisAdd BLAST150

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The kinesin motor domain binds to microtubules with high affinity and has a robust ATPase activity but a very slow motility. The kinesin motor domain protects microtubules from cold depolymerization. Binds to each tubulin heterodimer resulting in a microtubule complexes. Binds at the tubulin intradimer interface, at the crest of the protofilament, and orients slightly toward the next protofilament.1 Publication

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0245 Eukaryota
    COG5059 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156834

    KEGG Orthology (KO)

    More...
    KOi
    K17915

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    QEVSYHL

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0159

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00060 FHA, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.850.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000253 FHA_dom
    IPR027640 Kinesin-like_fam
    IPR032405 Kinesin_assoc
    IPR019821 Kinesin_motor_CS
    IPR001752 Kinesin_motor_dom
    IPR036961 Kinesin_motor_dom_sf
    IPR027417 P-loop_NTPase
    IPR008984 SMAD_FHA_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR24115 PTHR24115, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00498 FHA, 1 hit
    PF00225 Kinesin, 1 hit
    PF16183 Kinesin_assoc, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00380 KINESINHEAVY

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00240 FHA, 1 hit
    SM00129 KISc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49879 SSF49879, 1 hit
    SSF52540 SSF52540, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50006 FHA_DOMAIN, 1 hit
    PS00411 KINESIN_MOTOR_1, 1 hit
    PS50067 KINESIN_MOTOR_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

    L0N7N1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSVHTSHSRH NIGSLEVSSS QKISASSGLV HSSRLELHLK ADMSECENHD
    60 70 80 90 100
    PFVNAGSKTI DINSTYVISA CKKTRETPVT SDPRRLSLQR RATCGDRESS
    110 120 130 140 150
    LLGSELGNRR TADTSLRLQR RHGRADYVGK WETLNPVGGN PGSDSASQAS
    160 170 180 190 200
    RTEAKGVNND TRVLSSVVSV KDSNDTGLTR CKDPGPPVGA SNEKVTVKDT
    210 220 230 240 250
    NSRAPVGSQR QTEAMRSGHL VVQLTESKSD TPVSGGRNSH RGNAGKDTAK
    260 270 280 290 300
    QVGTFGSSDT RTPVKCVLEH RWTPRHDPPP PKSPALSTPK NNGKDIPKHG
    310 320 330 340 350
    STFRSASSES RTPVKCVPEH RWTPRHDLPP PKSPALSTLK NRIASPRVKP
    360 370 380 390 400
    RPKSSLFANK RESSRESTLP PEENSLVQKT FTEPDSLKVE NSQVTVAVRV
    410 420 430 440 450
    RPFSKREKTE KASQVVFTNG EEITVEHPDM KQVYSFIYDV SFWSFDECHP
    460 470 480 490 500
    GYASQTTVYE TLAAPLLDRA FEGYNTCLFA YGQTGSGKSY TMMGLNEEPG
    510 520 530 540 550
    IIPRFCEDLF AQIAKKQTSE VSYHLEMSFF EVYNEKIHDL LVCKGENGQR
    560 570 580 590 600
    KQPLRAREHP VSGPYVEGLS MNVVSSYSDI QSWLELGNKQ RATAATGMND
    610 620 630 640 650
    KSSRSHSVFT LVMTQTKTEV VEGEEHDHRI TSRINLVDLA GSERCSTAHS
    660 670 680 690 700
    SGQRLKEGVS INKSLLTLGK VISALSEQAN GKRVFIPYRE STLTWLLKES
    710 720 730 740 750
    LGGNSKTAMI ATVSPAASNI EETLSTLRYA TQARLIVNIA KVNEDMNAKL
    760 770 780 790 800
    IRELKAEIEK LKAAQRSNRN IDPERYRLCR QEITSLRMKL HQQERDMAEI
    810 820 830 840 850
    QRVWKEKFEQ AEKRKLQETK ELQKAGVTFQ MDNHLPNLVN LNEDPQLSEM
    860 870 880 890 900
    LLYMVKEGVT TVGKHTPSSS HDIQLSGVLI ADDHCTIRNF GGTVSIVPAG
    910 920 930 940 950
    EAKTYVNGTH ISEPTVLHHG DRVVLGGDHY FRFNHPVEVQ KGKKLSSRNN
    960 970 980 990 1000
    LTTSEGPKDF EFAKNELLTA QRSRLEAEIK DAQLKAKEEM MQGIQIAKEM
    1010 1020 1030 1040 1050
    AQQELSSQKA VYERKIQALE AELREESQRK RLEELNNQKA SHKIEELERA
    1060 1070 1080 1090 1100
    KQHLEQEVYV NKRRLEMETL ATKQALEDHR IRHARILEAL EIEKQKIAEE
    1110 1120 1130 1140 1150
    VQMLQENRGN RDKTFTIQPN WNSMKLSTMI QEANAISDKF KKCYIFGRHD
    1160 1170 1180 1190 1200
    ASDKGRSDTS VRVRNLQLGI STFWSLEKFE SKLAAMKELY ESNGGDRDED
    1210 1220 1230 1240 1250
    VFCDPADEWE PDITSTPVSS LSRRRSRSLM KNRRVSGCLH DIHPIQSMQS
    1260 1270 1280 1290 1300
    SHSSGLMEKP STIYSNSSES FLPGICKELI GSSIDFLGQS FDEEKTIADS
    1310 1320 1330 1340 1350
    LINNLLRLHN GVIAISKAHE EQDEESQDNL FSDRAAQALT IQVACAFEQL
    1360 1370 1380 1390 1400
    VVLFKHWLGD FLPCTGSARL EDELRQDIKK LGGYLQLFLQ GCCSDISSMV
    1410 1420 1430 1440 1450
    KEAQNKVMKI IQQAVQCVGQ LAVLKGSKLC VLENSSKVSS TQEFMAALQD
    1460 1470 1480 1490 1500
    GVTSGMKSLL DSGLETAQDL RQDLSRQSAR EEVTKQMKAS TVEWVGSLEN
    1510 1520 1530 1540 1550
    AVAEWRTKSF RTQAQEGSRQ QVSKLLSLAS EFLKLKSCLQ QTVEMIVSAL
    1560 1570 1580 1590 1600
    RGCPSDLHCL RSCTETICSL ARKLHSDFSA HSASAGSCGN ELPRADCEEL
    1610 1620 1630 1640 1650
    ESLAKSLLLC FECGESPGLS KPWESCSSNS KEEQCKSDRA DCGKSGPRRA
    1660 1670
    CEPHGDATPA VSSGDCTPNR IQWV
    Length:1,674
    Mass (Da):186,445
    Last modified:March 6, 2013 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A2616CA801C4183
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9Q3T3E9Q3T3_MOUSE
    Kinesin-like protein KIF14
    Kif14
    1,624Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0J9YUN5A0A0J9YUN5_MOUSE
    Kinesin-like protein KIF14
    Kif14
    497Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    L0N759L0N759_MOUSE
    Kinesin-like protein KIF14
    Kif14
    69Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB731728 mRNA Translation: BAM74185.1
    AC122127 Genomic DNA No translation available.
    AC126606 Genomic DNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS78693.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001274108.1, NM_001287179.2
    XP_006529792.1, XM_006529729.3

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Mm.458468

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000189413; ENSMUSP00000139698; ENSMUSG00000041498

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    381293

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:381293

    UCSC genome browser

    More...
    UCSCi
    uc007cuv.2 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB731728 mRNA Translation: BAM74185.1
    AC122127 Genomic DNA No translation available.
    AC126606 Genomic DNA No translation available.
    CCDSiCCDS78693.1
    RefSeqiNP_001274108.1, NM_001287179.2
    XP_006529792.1, XM_006529729.3
    UniGeneiMm.458468

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4OZQX-ray2.71A/B390-738[»]
    ProteinModelPortaliL0N7N1
    SMRiL0N7N1
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000044257

    PTM databases

    iPTMnetiL0N7N1
    PhosphoSitePlusiL0N7N1

    Proteomic databases

    PaxDbiL0N7N1
    PRIDEiL0N7N1

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000189413; ENSMUSP00000139698; ENSMUSG00000041498
    GeneIDi381293
    KEGGimmu:381293
    UCSCiuc007cuv.2 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    9928
    MGIiMGI:1098226 Kif14

    Phylogenomic databases

    eggNOGiKOG0245 Eukaryota
    COG5059 LUCA
    GeneTreeiENSGT00940000156834
    KOiK17915
    OMAiQEVSYHL
    OrthoDBiEOG091G0159

    Enzyme and pathway databases

    ReactomeiR-MMU-5625900 RHO GTPases activate CIT

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Kif14 mouse

    Protein Ontology

    More...
    PROi
    PR:L0N7N1

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000041498 Expressed in 28 organ(s), highest expression level in embryonic stem cell
    ExpressionAtlasiL0N7N1 baseline and differential
    GenevisibleiL0N7N1 MM

    Family and domain databases

    CDDicd00060 FHA, 1 hit
    Gene3Di3.40.850.10, 1 hit
    InterProiView protein in InterPro
    IPR000253 FHA_dom
    IPR027640 Kinesin-like_fam
    IPR032405 Kinesin_assoc
    IPR019821 Kinesin_motor_CS
    IPR001752 Kinesin_motor_dom
    IPR036961 Kinesin_motor_dom_sf
    IPR027417 P-loop_NTPase
    IPR008984 SMAD_FHA_dom_sf
    PANTHERiPTHR24115 PTHR24115, 1 hit
    PfamiView protein in Pfam
    PF00498 FHA, 1 hit
    PF00225 Kinesin, 1 hit
    PF16183 Kinesin_assoc, 1 hit
    PRINTSiPR00380 KINESINHEAVY
    SMARTiView protein in SMART
    SM00240 FHA, 1 hit
    SM00129 KISc, 1 hit
    SUPFAMiSSF49879 SSF49879, 1 hit
    SSF52540 SSF52540, 1 hit
    PROSITEiView protein in PROSITE
    PS50006 FHA_DOMAIN, 1 hit
    PS00411 KINESIN_MOTOR_1, 1 hit
    PS50067 KINESIN_MOTOR_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKIF14_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: L0N7N1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
    Last sequence update: March 6, 2013
    Last modified: December 5, 2018
    This is version 46 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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