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Protein

Putrescine aminotransferase

Gene

patA

Organism
Enterobacteriaceae bacterium (strain FGI 57)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine.UniRule annotation

Catalytic activityi

Putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: putrescine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Putrescine aminotransferase (patA)
This subpathway is part of the pathway putrescine degradation, which is itself part of Amine and polyamine degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-aminobutanal from putrescine (transaminase route), the pathway putrescine degradation and in Amine and polyamine degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00188;UER00290

Names & Taxonomyi

Protein namesi
Recommended name:
Putrescine aminotransferaseUniRule annotation (EC:2.6.1.82UniRule annotation)
Alternative name(s):
Putrescine--2-oxoglutaric acid transaminaseUniRule annotation
Short name:
PATUniRule annotation
Short name:
PATaseUniRule annotation
Gene namesi
Name:patAUniRule annotation
Ordered Locus Names:D782_0607Imported
OrganismiEnterobacteriaceae bacterium (strain FGI 57)Imported
Taxonomic identifieri693444 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceae
Proteomesi
  • UP000011002 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei339N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliL0LYE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili474 – 494Sequence analysisAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK09251
OMAiLIHGQYT
OrthoDBiPOG091H0A4W

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01276 Putres_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR017747 Putrescine_aminotransferase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03372 putres_am_tran, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

L0LYE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLHFSLVFI PIFSARVEVA QSLQYLIQYR VIRDPRELIL NRLPSSASAL
60 70 80 90 100
ACSAHALNLI EKRTLDHEEM KALNQEVREY FKEHVNPGFL EYRKSVTAGG
110 120 130 140 150
DYGAVEWQAG SLNTLVDTQG QEFIDCLGGF GIFNVGHRNP VVVSAVQNQL
160 170 180 190 200
VKQPLHSQEL LDPLRAMLAK TLAALAPGKL KYSFFSNSGT ESVEAALKLA
210 220 230 240 250
KAYQSPRGKF TFIATSGAFH GKSLGALSAT AKSTFRKPFM PLLPGFRHVP
260 270 280 290 300
FGNIDAMRLA LSECQKTGDD VAAVILEPIQ GEGGVILPPQ GYLPAVRKLC
310 320 330 340 350
DEFGALLIFD EVQTGMGRTG KMFACEHENV QPDILCLAKA LGGGVMPIGA
360 370 380 390 400
TIATEEVFSV LFDNPFLHTT TFGGNPLACA AALATINVLL TENLPAQAEQ
410 420 430 440 450
KGDMLLDGFR SLAREYPDLV REARGKGMLM AIEFVDNEIG YSFASEMFRQ
460 470 480 490 500
RVLVAGTLNN AKTIRIEPPL TLTIEQCELV LKATRKALAS LRVEKQVTTE

Q
Length:501
Mass (Da):54,716
Last modified:March 6, 2013 - v1
Checksum:iCE9B0775224748F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003938 Genomic DNA Translation: AGB76663.1

Genome annotation databases

EnsemblBacteriaiAGB76663; AGB76663; D782_0607
KEGGiebf:D782_0607
PATRICifig|693444.3.peg.590

Similar proteinsi

Entry informationi

Entry nameiL0LYE8_ENTBF
AccessioniPrimary (citable) accession number: L0LYE8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: March 28, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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