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Protein
Submitted name:

Malate dehydrogenase, NAD-dependent

Gene

Metho_2062

Organism
Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Active sitei174Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation

Enzyme and pathway databases

BioCyciMHOL867904:G139N-1980-MONOMER

Names & Taxonomyi

Protein namesi
Submitted name:
Malate dehydrogenase, NAD-dependentImported
Gene namesi
Ordered Locus Names:Metho_2062Imported
OrganismiMethanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1)Imported
Taxonomic identifieri867904 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanomethylovorans
Proteomesi
  • UP000010866 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 141Ldh_1_NInterPro annotationAdd BLAST139
Domaini146 – 302Ldh_1_CInterPro annotationAdd BLAST157

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

KOiK00024
OMAiMDLMQTA
OrthoDBiPOG093Z062E

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

L0L1F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKLSVIGAG NVGASTVQRL AESKLGDIVM LDVVPGLPQG KALDLMQAAP
60 70 80 90 100
LMGYDVNIKG TNDYADIEGS DIVIITAGIA RKPGMTRDDL LNINAKITRE
110 120 130 140 150
VCGNIREYAP KSIVITVTNP LDIITYAVYK CTGFGKKRVF GMSGLLDSSR
160 170 180 190 200
FASFVAMEVG CSVKDVDAMV LGGHGDSMVP LPQYTTVSGI PISEFLPKDT
210 220 230 240 250
IDRLVARTID AGAEIVSLLK EGSAFYAPSA AIVSMVDAII NDSGRVVPVS
260 270 280 290 300
VYLEGEYGFS DLCLGVPAKL GKNGIEKVIE IQLSEEQIVA LSKSEKSVRH
310
GIGKLDMGLY EKAFLV
Length:316
Mass (Da):33,594
Last modified:March 6, 2013 - v1
Checksum:i19D9DEE24D532EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003362 Genomic DNA Translation: AGB50228.1
RefSeqiWP_015325393.1, NC_019977.1

Genome annotation databases

EnsemblBacteriaiAGB50228; AGB50228; Metho_2062
GeneIDi14406575
KEGGimhz:Metho_2062

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003362 Genomic DNA Translation: AGB50228.1
RefSeqiWP_015325393.1, NC_019977.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAGB50228; AGB50228; Metho_2062
GeneIDi14406575
KEGGimhz:Metho_2062

Phylogenomic databases

KOiK00024
OMAiMDLMQTA
OrthoDBiPOG093Z062E

Enzyme and pathway databases

BioCyciMHOL867904:G139N-1980-MONOMER

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiL0L1F9_METHD
AccessioniPrimary (citable) accession number: L0L1F9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: October 10, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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