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Protein

NAD kinase

Gene

nadK

Organism
Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Proton acceptorUniRule annotation1
Binding sitei68NADUniRule annotation1
Binding sitei142NADUniRule annotation1
Binding sitei159NADUniRule annotation1
Binding sitei161NADUniRule annotation1
Binding sitei196NAD; via carbonyl oxygenUniRule annotation1
Binding sitei230NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 64NADUniRule annotation2
Nucleotide bindingi131 – 132NADUniRule annotation2
Nucleotide bindingi172 – 177NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingUniRule annotation, NADUniRule annotation, NADPUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMFOR593750:G1HDW-1491-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Metfor_1503Imported
OrganismiMethanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)Imported
Taxonomic identifieri593750 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
Proteomesi
  • UP000010824 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

L0HFG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAVIVSRID NAEALAFARS IRATLSEASC PAEFDHDTAI AVGESGPRLA
60 70 80 90 100
ETDADIVIVI GGDGTILRTI QQLGSPVPVL GINWGEVGFL ADLETADALP
110 120 130 140 150
FLRNLVHGFT VEERMRISLA KDGVPLGTAL NEALIVTTRP AKMLRFSIII
160 170 180 190 200
DGVVAEQFRA DGLLVSTPTG STAYAMSAGG PIVDPRIQGF LLVPLAPYML
210 220 230 240 250
SSRPHLISEG RRLEIRLESA KPAKLVLDGQ QTIDLGTSSQ IHIQRSPVPA
260 270
QFVDVKRNFF EKVDKKLRNL
Length:270
Mass (Da):29,086
Last modified:March 6, 2013 - v1
Checksum:i0BA64E9C2C5EF554
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003167 Genomic DNA Translation: AGB02536.1
RefSeqiWP_015285499.1, NC_019943.1

Genome annotation databases

EnsemblBacteriaiAGB02536; AGB02536; Metfor_1503
GeneIDi14307892
KEGGimfo:Metfor_1503

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003167 Genomic DNA Translation: AGB02536.1
RefSeqiWP_015285499.1, NC_019943.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAGB02536; AGB02536; Metfor_1503
GeneIDi14307892
KEGGimfo:Metfor_1503

Phylogenomic databases

KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Enzyme and pathway databases

BioCyciMFOR593750:G1HDW-1491-MONOMER

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 1 hit
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiL0HFG1_METFS
AccessioniPrimary (citable) accession number: L0HFG1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: November 7, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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