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Entry version 50 (07 Oct 2020)
Sequence version 1 (06 Mar 2013)
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Protein

Genome polyprotein

Gene
N/A
Organism
Deformed wing virus
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase
Biological processViral RNA replicationARBA annotation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Genome polyproteinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDeformed wing virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri198112 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesIflaviridaeIflavirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host membraneARBA annotation, Membrane, VirionARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
L0CTV4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1446 – 1612SF3 helicaseInterPro annotationAdd BLAST167
Domaini2633 – 2763RdRp catalyticInterPro annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 226DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1697 – 1717Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00205, rhv_like, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.10.10, 2 hits
2.60.120.20, 3 hits
3.30.70.270, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014872, Dicistrovirus_capsid-polyPr_C
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08762, CRPV_capsid, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 2 hits
PF00910, RNA_helicase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

L0CTV4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFSCGTLSY SAAAQAPSVA HAPRTWEVDE ARRRPVIKRL ALEQERMRNV
60 70 80 90 100
RDVDVYDQAT WEQEDARDNE FLMEQLNNLY TIYSIAERCA RRPIKEHSPI
110 120 130 140 150
SVSNRFAPLE SLKVEVGQEA SECIFKKPKY TRVCKKVKRV ATRFVREKVV
160 170 180 190 200
RPMCPRSPML LFKLKKIIYD LHLYRLRKQI RLLRRQKQRE YELECVTSLL
210 220 230 240 250
QLSDPVQAKP EMDNPNPGPD GEGEVELEKD SNVVLTTQRD PSTSIPAPVS
260 270 280 290 300
VKWSRWTSND VVDDYATITS RWYQIAEFVW SKDDPFDKEL ARLILPRALL
310 320 330 340 350
SSIEANSDAI CDVPNTIPFK VHAYWRGDME VRVQINSNKF QVGQLQATWY
360 370 380 390 400
YSDHENLNIS SKRSVYGFSQ MDHALISASA SNEAKLVIPY KHVYPFLPTR
410 420 430 440 450
IVPDWTTGIL DMGALNIRVI APLRMSATGP TTCNVVVFIK LNNSEFTGTS
460 470 480 490 500
SGKFYASQIR VKPEMDRILN LAEGLLNNTI GGNNMDNPSY QQSPRHFVPT
510 520 530 540 550
GMHSLALGTN LVEPLHALRL DAAGTTQHPV GCAPDEDMTV SSIASRYGLI
560 570 580 590 600
RQVQWKKDHA KGALLLQLDA DPFVEQRIEG TNPISLYWFA PVGVVSSMFM
610 620 630 640 650
QWRGSLEYRF DIIASQFHTG RLIVGYVPGL TASLQLQMDY MKLKSSSYVV
660 670 680 690 700
FDLQESNSFT FEVPYVSYRP WWVRKYGGNY LPSSTDAPST LFMYVQVPLI
710 720 730 740 750
PMEAVSDTID INVYVRGGSS FEVCVPVQPS LGLNWNTDFI LRNDEEYRAK
760 770 780 790 800
TGYAPYYAGV WHSFNNSNSL VFRWGSASDQ IAQWPTISVP RGELAFLRIR
810 820 830 840 850
DGKQAAVGTQ PWRTMVVWPS GHGYNIGIPT YNADGARQLA QHLYGGGSLT
860 870 880 890 900
DEKAKQLFVP ANQQGPGKVS NGNPVWEVMR APLATQRAHV QDFEFIEAIP
910 920 930 940 950
EGEESRNTTV LDTTTTLQSS GFGRAFFGEA FNDLKTLMRR YQLYGQLLLS
960 970 980 990 1000
VTTDKDIDHC MFTFPCLPQG LALDIGSAGS PHEIFNRCRD GIIPLIASGY
1010 1020 1030 1040 1050
RFYRGDLRYK IVFPSNVNSN IWVQHRPDRR LEGWSAAKIV NCDAVSTGQG
1060 1070 1080 1090 1100
VYNHGYASHI QITRVNNVIE LEVPFYNATC YNYLQAFNAS SAASSYAVSL
1110 1120 1130 1140 1150
GEISVGFQAT SDDIASIVNK PVTIYYSIGD GMQFSQWVGY QPMMILDQLP
1160 1170 1180 1190 1200
APVVRAVPEG PIAKIKNFFH QTADEVREAQ AAKMREDMGM VVQDVIGELS
1210 1220 1230 1240 1250
QAIPDLQQPE VQANVFSLVS QLVHAIIGTS LKTVAWAIVS IFVTLGLIGR
1260 1270 1280 1290 1300
EMMHSVITVV KRLLEKYHLA TQPQESASSG TVISAVPEAP NAEAEEASAW
1310 1320 1330 1340 1350
VSIIYNGVCN MLNVAAQKPK QFKDWVKLAT VDFSNTCRGS NQVFVFFKNT
1360 1370 1380 1390 1400
FEVLKKMWGY VFCQSNPAAR LLKAVNDEPE ILKAWVKECL YLDDPKFRMR
1410 1420 1430 1440 1450
RAHDQEYIER VFAAHSYGQI LLHDLTAEMN QSRNLSVFTR VYDQISKLKT
1460 1470 1480 1490 1500
DLMEMGSNPY IRRDCFTICM CGASGIGKSY FTDSLCRELL RASRTPVTTG
1510 1520 1530 1540 1550
IKCVVNPLSD YWDQCDFQPV LWVDDMWSVE TSTTLDKQLN MLFQVHSPIV
1560 1570 1580 1590 1600
LSPPKADLEG KKMRYNPEIF IYNTNKPFPR FDRIAMEAIY RRRNVLIECK
1610 1620 1630 1640 1650
ANEEKKRGCK HCENDIPIAE CSPKMLKDFH HIKFRYAHDV CNSETTWSEW
1660 1670 1680 1690 1700
MTYNEFLERI TPVYMANRRK ANESFRMRVD EMQMLRMDEP LEGDNILNKY
1710 1720 1730 1740 1750
VEVNQRLVEE MKAFKERTLW SDLHRVGAEI SASVKKALPT ISITEKLPHW
1760 1770 1780 1790 1800
TVQCGIAKPE MDHAYEVMSS YAAGMNAEIE AHEQVRRSSV ECQYAEPQAP
1810 1820 1830 1840 1850
RNPDDEGPTI DEELMGDTEF ASQALERLVD EGYITGKQKK YIATWCSKRR
1860 1870 1880 1890 1900
EHSADFDLVW TDNLRVLSAY VLERSSSTRL STDDVKLYKT ITMLHQKYDT
1910 1920 1930 1940 1950
SECAKCQHWY APLTDVYVDD KKLFWCQKEK KTLIDVRKLS KEDVTVQSKL
1960 1970 1980 1990 2000
INLSVPCGEV CVLHSKYFNY LFHKAWLCEN PTWRLIYNGT KKGMPEYFMN
2010 2020 2030 2040 2050
CVDEISLDSK FGKVRVWLQA IIDKYLTRPG KMIRDFLFKW WPQVAYVLSL
2060 2070 2080 2090 2100
LGIIGITAYE MRNPKPTSEE LADHRVNRHC TSDFCSPGQA SPQGLKYRVA
2110 2120 2130 2140 2150
VTDKAPRIHR LPVTTRPQGS TQQVDAAVNK ILQNMVYIGV VFPKVPGSKW
2160 2170 2180 2190 2200
RDINFRCLML HNRQCLMLRH YIESTAAFPE GTKYYFKYIH NQETRMSGDI
2210 2220 2230 2240 2250
SGIEIDLLNL PRLYYGGLAG EESFDSNIVL VTMPNRIPEC KSIIKFIASH
2260 2270 2280 2290 2300
NEHIRAQNDG VLVTGDHTQL LAFENNNKTP ISINADGSYE VILQGVYTYP
2310 2320 2330 2340 2350
YHGDGVCGPK LLSRNLQRPI IGIHVAGTEG LHGFGVAEPL VHEMFTGKAI
2360 2370 2380 2390 2400
ESEREPYERV YELPLRELDE SDIGLDTDLY PIGKVDAKLA HAQSPSTGIK
2410 2420 2430 2440 2450
KTLIHGTFDV RTEPNPMSSR DPRIAPHDPL KLGCEKHGMP CSPFNRKHLE
2460 2470 2480 2490 2500
LATNHLKEKL VSVVKPINGC KIRSLQDAVC GVPGLDGFDS ISWNTSAGFP
2510 2520 2530 2540 2550
LSSLKPPGTS GKRWLFDIEL QDSGCYLLRG MPPELEIQLS TTQLMRKKGI
2560 2570 2580 2590 2600
KPHTIFTDCL KDTCLPVEKC RIPGKTRIFS ISPVQFTIPF RQYYLDFMAS
2610 2620 2630 2640 2650
YRAARLNAEH GIGIDVNSLE WTNLATSLSK YGTHIVTGDY KNFGPGLDSD
2660 2670 2680 2690 2700
VAASAFEIII DWVLHYTEED NKDEMKRVMW TVAQEILAPS HLCRDLVYRV
2710 2720 2730 2740 2750
PCGIPSGSPI TDILNTISNC LLIRLAWLGI TDLPLSEFSQ NVVLVCYGDD
2760 2770 2780 2790 2800
LIMNVSDNMI DKFNAVTIGR FFSQYKMEFT DQDKSGNTVK WRTLQTATFL
2810 2820 2830 2840 2850
KHGFLKHPTR PVFLANLDKV SVEGTTNWTH ARGLGRRAAT IENAKQALEL
2860 2870 2880 2890
AFGWGPEYFN YVRSTIKMAF DKLGIYEDLI TWEEMDVRCY ASA
Length:2,893
Mass (Da):328,037
Last modified:March 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A1FD5B5CD0E8F30
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JX878304 Genomic RNA Translation: AGA20422.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX878304 Genomic RNA Translation: AGA20422.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5L7Qelectron microscopy3.44A902-1159[»]
5L8Qelectron microscopy3.20A902-1159[»]
5MUPelectron microscopy3.80A902-1159[»]
5MV5electron microscopy3.10A902-1159[»]
5MV6electron microscopy3.50A902-1159[»]
6F5Jelectron microscopy3.10A902-1159[»]
SMRiL0CTV4
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

CDDicd00205, rhv_like, 2 hits
Gene3Di2.40.10.10, 2 hits
2.60.120.20, 3 hits
3.30.70.270, 1 hit
InterProiView protein in InterPro
IPR014872, Dicistrovirus_capsid-polyPr_C
IPR043502, DNA/RNA_pol_sf
IPR000605, Helicase_SF3_ssDNA/RNA_vir
IPR014759, Helicase_SF3_ssRNA_vir
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001676, Picornavirus_capsid
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR033703, Rhv-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR029053, Viral_coat
PfamiView protein in Pfam
PF08762, CRPV_capsid, 1 hit
PF00680, RdRP_1, 1 hit
PF00073, Rhv, 2 hits
PF00910, RNA_helicase, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50507, RDRP_SSRNA_POS, 1 hit
PS51218, SF3_HELICASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL0CTV4_9VIRU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: L0CTV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: October 7, 2020
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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