Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Geitlerinema sp. PCC 7407
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

[Biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseImported, TransferaseUniRule annotationSAAS annotationImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP1173025:G1HCN-1631-MONOMER
UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:2.1.3.15UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:GEI7407_1566Imported
OrganismiGeitlerinema sp. PCC 7407Imported
Taxonomic identifieri1173025 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeOscillatorialesColeofasciculaceaeGeitlerinema
Proteomesi
  • UP000010383 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 298CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST255

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili17 – 37Sequence analysisAdd BLAST21
Coiled coili282 – 302Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK01962
OrthoDBiPOG091H0647

Family and domain databases

HAMAPiMF_00823 AcetylCoA_CT_alpha, 1 hit
InterProiView protein in InterPro
IPR001095 Acetyl_CoA_COase_a_su
IPR029045 ClpP/crotonase-like_dom_sf
IPR011763 COA_CT_C
PANTHERiPTHR42853 PTHR42853, 1 hit
PfamiView protein in Pfam
PF03255 ACCA, 1 hit
PRINTSiPR01069 ACCCTRFRASEA
SUPFAMiSSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR00513 accA, 1 hit
PROSITEiView protein in PROSITE
PS50989 COA_CT_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

K9S606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSTRRPIL LDFEKPLAEL EARITQIREL AEENDVDVSG EIRQLESRAM
60 70 80 90 100
QLRQEIFSSL TPAQRLQVAR HPRRPSTLDY IQSITDEWIE LHGDRGGADD
110 120 130 140 150
PALVGGIGRL NGQPVVFLGH QKGRDTKDNV ARNFGMASPG GYRKAMRLME
160 170 180 190 200
HADRFGMPII SFIDTPGAYP GPEGERLGQG EAIAYNLREM FRLEVPIICT
210 220 230 240 250
VIGEGGSGGA LGIGVAERLL MFEHSVYYVA SPEACSAILW KDAGKAPQAA
260 270 280 290 300
EALRITAWDL KNLGILDDLL PEPVGGAHSD PIKAAAILKE ALVRNLNELN
310 320
QLTSHQRRDL RYQKFRNIGV FTEATA
Length:326
Mass (Da):35,916
Last modified:March 6, 2013 - v1
Checksum:i71A8F3667C476A39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003591 Genomic DNA Translation: AFY66057.1
RefSeqiWP_015171624.1, NC_019703.1

Genome annotation databases

EnsemblBacteriaiAFY66057; AFY66057; GEI7407_1566
KEGGigei:GEI7407_1566
PATRICifig|1173025.3.peg.1748

Similar proteinsi

Entry informationi

Entry nameiK9S606_9CYAN
AccessioniPrimary (citable) accession number: K9S606
Entry historyiIntegrated into UniProtKB/TrEMBL: March 6, 2013
Last sequence update: March 6, 2013
Last modified: June 20, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health