UniProtKB - K9N7D2 (ORF5_MERS1)
Protein
Non-structural protein ORF5
Gene
ORF5
Organism
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1)
Status
Functioni
Seems to play a role in the inhibition of host innate immune repsonse.1 Publication
GO - Biological processi
- suppression by virus of host innate immune response Source: UniProtKB-KW
- suppression by virus of host type I interferon production Source: UniProtKB
Keywordsi
Biological process | Host-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion |
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural protein ORF5Short name: ORF5 |
Gene namesi | Name:ORF5 |
Organismi | Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) |
Taxonomic identifieri | 1263720 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus › |
Virus hosti | Camelus dromedarius (Dromedary) (Arabian camel) [TaxID: 9838] Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host membrane Curated; Multi-pass membrane protein Curated
- Host Golgi apparatus 1 Publication Note: Localizes also in the host perinuclear area.
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 89 – 109 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell Golgi apparatus Source: UniProtKB-SubCell
- host cell membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host Golgi apparatus, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422438 | 1 – 224 | Non-structural protein ORF5Add BLAST | 224 |
i Sequence
Sequence statusi: Complete.
K9N7D2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFSASLFKP VQLVPVSPAF HRIESTDSIV FTYIPASGYV AALAVNVCLI
60 70 80 90 100
PLLLLLRQDT CRRSIIRTMV LYFLVLYNFL LAIVLVNGVH YPTGSCLIAF
110 120 130 140 150
LVILIILWFV DRIRFCLMLN SYIPLFDMRS HFIRVSTVSS HGMVPVIHTK
160 170 180 190 200
PLFIRNFDQR CSCSRCFYLH SSTYIECTYI SRFSKISLVS VTDFSLNGNV
210 220
STVFVPATRD SVPLHIIAPS SLIV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13311.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13311.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ORF5_MERS1 | |
Accessioni | K9N7D2Primary (citable) accession number: K9N7D2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2013 |
Last sequence update: | March 6, 2013 | |
Last modified: | December 2, 2020 | |
This is version 27 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |