UniProtKB - K9N643 (ORF4B_MERS1)
Protein
Non-structural protein ORF4b
Gene
ORF4b
Organism
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1)
Status
Functioni
Plays a role in the inhibition of host innate immunity by inhibiting the interaction between host IKBKE and MAVS. In turn, this inhibition prevents the production of host interferon beta. Additionally, inhibits host NF-kappa-B by interacting with host KPNA4 and thereby preventing the translocation of the NF-kappa-B complex into the nucleus by this importin (PubMed:29370303).4 Publications
GO - Biological processi
- suppression by virus of host IKBKE activity Source: UniProtKB-KW
- suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB-KW
- suppression by virus of host type I interferon production Source: UniProtKB
Keywordsi
Enzyme and pathway databases
SIGNORi | K9N643 |
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural protein ORF4bShort name: ORF4b |
Gene namesi | Name:ORF4b |
Organismi | Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) |
Taxonomic identifieri | 1263720 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus › |
Virus hosti | Camelus dromedarius (Dromedary) (Arabian camel) [TaxID: 9838] Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host nucleus 4 Publications
- host nucleolus 1 Publication
- Host cytoplasm 1 Publication Note: Mainly localized in the host nucleus.3 Publications
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB-SubCell
- host cell nucleolus Source: UniProtKB-SubCell
- host cell nucleus Source: UniProtKB
Keywords - Cellular componenti
Host cytoplasm, Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422437 | 1 – 246 | Non-structural protein ORF4bAdd BLAST | 246 |
Interactioni
Subunit structurei
Interacts with host KPNA4; this interaction inhibits the nuclear import of NF-kappa-B complex.
1 PublicationBinary interactionsi
Hide detailsK9N643
Protein-protein interaction databases
IntActi | K9N643, 12 interactors |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 22 – 38 | Nuclear localization motif1 PublicationAdd BLAST | 17 |
i Sequence
Sequence statusi: Complete.
K9N643-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEESLMDVPS TSGTQVYSRK ARKRSHSPTK KLRYVKRRFS LLRPEDLSVI
60 70 80 90 100
VQPTHYVRVT FSDPNMWYLR SGHHLHSVHN WLKPYGGQPV SEYHITLALL
110 120 130 140 150
NLTDEDLARD FSPIALFLRN VRFELHEFAL LRKTLVLNAS EIYCANIHRF
160 170 180 190 200
KPVYRVNTAI PTIKDWLLVQ GFSLYHSGLP LHMSISKLHA LDDVTRNYII
210 220 230 240
TMPCFRTYPQ QMFVTPLAVD VVSIRSSNQG NKQIVHSYPI LHHPGF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13310.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13310.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | K9N643, 12 interactors |
Enzyme and pathway databases
SIGNORi | K9N643 |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ORF4B_MERS1 | |
Accessioni | K9N643Primary (citable) accession number: K9N643 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2013 |
Last sequence update: | March 6, 2013 | |
Last modified: | February 10, 2021 | |
This is version 27 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |