UniProtKB - K9N638 (R1A_MERS1)
Replicase polyprotein 1a
1a
Functioni
Catalytic activityi
- TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position. EC:3.4.22.69
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1592 | For PL-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1759 | For PL-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3288 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 3395 | For 3CL-PRO activityPROSITE-ProRule annotation | 1 | |
Metal bindingi | 4311 | Zinc | 1 | |
Metal bindingi | 4314 | Zinc | 1 | |
Metal bindingi | 4320 | Zinc | 1 | |
Metal bindingi | 4327 | Zinc | 1 | |
Metal bindingi | 4354 | Zinc | 1 | |
Metal bindingi | 4357 | Zinc | 1 | |
Metal bindingi | 4365 | Zinc | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1672 – 1709 | C4-typePROSITE-ProRule annotationAdd BLAST | 38 | |
Zinc fingeri | 4311 – 4327 | Add BLAST | 17 | |
Zinc fingeri | 4354 – 4367 | Add BLAST | 14 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
- single-stranded RNA binding Source: InterPro
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- transferase activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- induction by virus of catabolism of host mRNA Source: UniProtKB-KW
- induction by virus of host autophagy Source: UniProtKB-KW
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host IRF3 activity Source: UniProtKB-KW
- suppression by virus of host ISG15 activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- viral genome replication Source: InterPro
- viral protein processing Source: InterPro
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1aShort name: pp1a Alternative name(s): ORF1a polyprotein Cleaved into the following 11 chains: Alternative name(s): Leader protein Alternative name(s): p65 homolog Alternative name(s): Non-structural protein 3 Short name: nsp3 Alternative name(s): nsp5 Alternative name(s): Growth factor-like peptide Short name: GFL |
Gene namesi | ORF Names:1a |
Organismi | Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) |
Taxonomic identifieri | 1263720 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus › |
Virus hosti | Camelus dromedarius (Dromedary) (Arabian camel) [TaxID: 9838] Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host membrane ; Multi-pass membrane protein
- Host cytoplasm Note: Localizes in virally-induced cytoplasmic double-membrane vesicles.By similarity
- Host membrane Curated; Multi-pass membrane protein Curated
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2105 – 2125 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2177 – 2197 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2281 – 2301 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2305 – 2325 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2330 – 2350 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2757 – 2777 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3028 – 3048 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3062 – 3082 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3104 – 3124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3125 – 3145 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3559 – 3579 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3593 – 3613 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3618 – 3638 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3664 – 3684 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3691 – 3711 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3740 – 3760 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3765 – 3785 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cytoplasm, Host membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422454 | 1 – 193 | Host translation inhibitor nsp1By similarityAdd BLAST | 193 | |
ChainiPRO_0000422455 | 194 – 853 | Non-structural protein 2By similarityAdd BLAST | 660 | |
ChainiPRO_0000422456 | 854 – 2740 | Papain-like proteinaseBy similarityAdd BLAST | 1887 | |
ChainiPRO_0000422457 | 2741 – 3247 | Non-structural protein 4Sequence analysisAdd BLAST | 507 | |
ChainiPRO_0000422458 | 3248 – 3553 | 3C-like proteinaseBy similarityAdd BLAST | 306 | |
ChainiPRO_0000422459 | 3554 – 3845 | Non-structural protein 6By similarityAdd BLAST | 292 | |
ChainiPRO_0000422460 | 3846 – 3928 | Non-structural protein 7By similarityAdd BLAST | 83 | |
ChainiPRO_0000422461 | 3929 – 4127 | Non-structural protein 8By similarityAdd BLAST | 199 | |
ChainiPRO_0000422462 | 4128 – 4237 | Non-structural protein 9By similarityAdd BLAST | 110 | |
ChainiPRO_0000422463 | 4238 – 4377 | Non-structural protein 10By similarityAdd BLAST | 140 | |
ChainiPRO_0000422464 | 4378 – 4391 | Non-structural protein 11By similarityAdd BLAST | 14 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 193 – 194 | CleavageBy similarity | 2 | |
Sitei | 853 – 854 | Cleavage; by PL-PROBy similarity | 2 | |
Sitei | 2740 – 2741 | Cleavage; by PL-PROBy similarity | 2 | |
Sitei | 3247 – 3248 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3553 – 3554 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3845 – 3846 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3928 – 3929 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4127 – 4128 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4237 – 4238 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4377 – 4378 | Cleavage; by 3CL-PROBy similarity | 2 |
Proteomic databases
PRIDEi | K9N638 |
Interactioni
Subunit structurei
Nsp2 interacts with host PHB and PHB2. 3CL-PRO exists as monomer and homodimer. Nsp4 interacts with PL-PRO and nsp6. Only the homodimer shows catalytic activity. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer dsRNA-encircling ring structure. Nsp9 is a dimer.
By similarityProtein-protein interaction databases
IntActi | K9N638, 1 interactor |
Structurei
Secondary structure
3D structure databases
SMRi | K9N638 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1110 – 1276 | MacroPROSITE-ProRule annotationAdd BLAST | 167 | |
Domaini | 1552 – 1823 | Peptidase C16PROSITE-ProRule annotationAdd BLAST | 272 | |
Domaini | 3248 – 3553 | Peptidase C30PROSITE-ProRule annotationAdd BLAST | 306 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2040 – 2363 | HD1Add BLAST | 324 | |
Regioni | 2761 – 3171 | HD2Add BLAST | 411 | |
Regioni | 3571 – 3785 | HD3Add BLAST | 215 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1672 – 1709 | C4-typePROSITE-ProRule annotationAdd BLAST | 38 | |
Zinc fingeri | 4311 – 4327 | Add BLAST | 17 | |
Zinc fingeri | 4354 – 4367 | Add BLAST | 14 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerFamily and domain databases
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.220.20, 1 hit 3.40.50.11020, 1 hit 3.90.70.90, 1 hit |
InterProi | View protein in InterPro IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR002589, Macro_dom IPR043472, Macro_dom-like IPR042570, NAR_sf IPR036333, NSP10_sf_CoV IPR021590, NSP1_bCoV IPR024375, NSP3_bCoV IPR032592, NSP3_NAR_bCoV IPR038400, NSP3_SUD-M_sf_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR018995, RNA_synth_NSP10_CoV |
Pfami | View protein in Pfam PF16251, bCoV_NAR, 1 hit PF11501, bCoV_NSP1, 1 hit PF11633, bCoV_SUD_M, 1 hit PF09401, CoV_NSP10, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSFVAGVTAQ GARGTYRAAL NSEKHQDHVS LTVPLCGSGN LVEKLSPWFM
60 70 80 90 100
DGENAYEVVK AMLLKKEPLL YVPIRLAGHT RHLPGPRVYL VERLIACENP
110 120 130 140 150
FMVNQLAYSS SANGSLVGTT LQGKPIGMFF PYDIELVTGK QNILLRKYGR
160 170 180 190 200
GGYHYTPFHY ERDNTSCPEW MDDFEADPKG KYAQNLLKKL IGGDVTPVDQ
210 220 230 240 250
YMCGVDGKPI SAYAFLMAKD GITKLADVEA DVAARADDEG FITLKNNLYR
260 270 280 290 300
LVWHVERKDV PYPKQSIFTI NSVVQKDGVE NTPPHYFTLG CKILTLTPRN
310 320 330 340 350
KWSGVSDLSL KQKLLYTFYG KESLENPTYI YHSAFIECGS CGNDSWLTGN
360 370 380 390 400
AIQGFACGCG ASYTANDVEV QSSGMIKPNA LLCATCPFAK GDSCSSNCKH
410 420 430 440 450
SVAQLVSYLS ERCNVIADSK SFTLIFGGVA YAYFGCEEGT MYFVPRAKSV
460 470 480 490 500
VSRIGDSIFT GCTGSWNKVT QIANMFLEQT QHSLNFVGEF VVNDVVLAIL
510 520 530 540 550
SGTTTNVDKI RQLLKGVTLD KLRDYLADYD VAVTAGPFMD NAINVGGTGL
560 570 580 590 600
QYAAITAPYV VLTGLGESFK KVATIPYKVC NSVKDTLTYY AHSVLYRVFP
610 620 630 640 650
YDMDSGVSSF SELLFDCVDL SVASTYFLVR LLQDKTGDFM STIITSCQTA
660 670 680 690 700
VSKLLDTCFE ATEATFNFLL DLAGLFRIFL RNAYVYTSQG FVVVNGKVST
710 720 730 740 750
LVKQVLDLLN KGMQLLHTKV SWAGSNISAV IYSGRESLIF PSGTYYCVTT
760 770 780 790 800
KAKSVQQDLD VILPGEFSKK QLGLLQPTDN STTVSVTVSS NMVETVVGQL
810 820 830 840 850
EQTNMHSPDV IVGDYVIISE KLFVRSKEED GFAFYPACTN GHAVPTLFRL
860 870 880 890 900
KGGAPVKKVA FGGDQVHEVA AVRSVTVEYN IHAVLDTLLA SSSLRTFVVD
910 920 930 940 950
KSLSIEEFAD VVKEQVSDLL VKLLRGMPIP DFDLDDFIDA PCYCFNAEGD
960 970 980 990 1000
ASWSSTMIFS LHPVECDEEC SEVEASDLEE GESECISETS TEQVDVSHEI
1010 1020 1030 1040 1050
SDDEWAAAVD EAFPLDEAED VTESVQEEAQ PVEVPVEDIA QVVIADTLQE
1060 1070 1080 1090 1100
TPVVSDTVEV PPQVVKLPSE PQTIQPEVKE VAPVYEADTE QTQSVTVKPK
1110 1120 1130 1140 1150
RLRKKRNVDP LSNFEHKVIT ECVTIVLGDA IQVAKCYGES VLVNAANTHL
1160 1170 1180 1190 1200
KHGGGIAGAI NAASKGAVQK ESDEYILAKG PLQVGDSVLL QGHSLAKNIL
1210 1220 1230 1240 1250
HVVGPDARAK QDVSLLSKCY KAMNAYPLVV TPLVSAGIFG VKPAVSFDYL
1260 1270 1280 1290 1300
IREAKTRVLV VVNSQDVYKS LTIVDIPQSL TFSYDGLRGA IRKAKDYGFT
1310 1320 1330 1340 1350
VFVCTDNSAN TKVLRNKGVD YTKKFLTVDG VQYYCYTSKD TLDDILQQAN
1360 1370 1380 1390 1400
KSVGIISMPL GYVSHGLDLI QAGSVVRRVN VPYVCLLANK EQEAILMSED
1410 1420 1430 1440 1450
VKLNPSEDFI KHVRTNGGYN SWHLVEGELL VQDLRLNKLL HWSDQTICYK
1460 1470 1480 1490 1500
DSVFYVVKNS TAFPFETLSA CRAYLDSRTT QQLTIEVLVT VDGVNFRTVV
1510 1520 1530 1540 1550
LNNKNTYRSQ LGCVFFNGAD ISDTIPDEKQ NGHSLYLADN LTADETKALK
1560 1570 1580 1590 1600
ELYGPVDPTF LHRFYSLKAA VHKWKMVVCD KVRSLKLSDN NCYLNAVIMT
1610 1620 1630 1640 1650
LDLLKDIKFV IPALQHAFMK HKGGDSTDFI ALIMAYGNCT FGAPDDASRL
1660 1670 1680 1690 1700
LHTVLAKAEL CCSARMVWRE WCNVCGIKDV VLQGLKACCY VGVQTVEDLR
1710 1720 1730 1740 1750
ARMTYVCQCG GERHRQIVEH TTPWLLLSGT PNEKLVTTST APDFVAFNVF
1760 1770 1780 1790 1800
QGIETAVGHY VHARLKGGLI LKFDSGTVSK TSDWKCKVTD VLFPGQKYSS
1810 1820 1830 1840 1850
DCNVVRYSLD GNFRTEVDPD LSAFYVKDGK YFTSEPPVTY SPATILAGSV
1860 1870 1880 1890 1900
YTNSCLVSSD GQPGGDAISL SFNNLLGFDS SKPVTKKYTY SFLPKEDGDV
1910 1920 1930 1940 1950
LLAEFDTYDP IYKNGAMYKG KPILWVNKAS YDTNLNKFNR ASLRQIFDVA
1960 1970 1980 1990 2000
PIELENKFTP LSVESTPVEP PTVDVVALQQ EMTIVKCKGL NKPFVKDNVS
2010 2020 2030 2040 2050
FVADDSGTPV VEYLSKEDLH TLYVDPKYQV IVLKDNVLSS MLRLHTVESG
2060 2070 2080 2090 2100
DINVVAASGS LTRKVKLLFR ASFYFKEFAT RTFTATTAVG SCIKSVVRHL
2110 2120 2130 2140 2150
GVTKGILTGC FSFVKMLFML PLAYFSDSKL GTTEVKVSAL KTAGVVTGNV
2160 2170 2180 2190 2200
VKQCCTAAVD LSMDKLRRVD WKSTLRLLLM LCTTMVLLSS VYHLYVFNQV
2210 2220 2230 2240 2250
LSSDVMFEDA QGLKKFYKEV RAYLGISSAC DGLASAYRAN SFDVPTFCAN
2260 2270 2280 2290 2300
RSAMCNWCLI SQDSITHYPA LKMVQTHLSH YVLNIDWLWF AFETGLAYML
2310 2320 2330 2340 2350
YTSAFNWLLL AGTLHYFFAQ TSIFVDWRSY NYAVSSAFWL FTHIPMAGLV
2360 2370 2380 2390 2400
RMYNLLACLW LLRKFYQHVI NGCKDTACLL CYKRNRLTRV EASTVVCGGK
2410 2420 2430 2440 2450
RTFYITANGG ISFCRRHNWN CVDCDTAGVG NTFICEEVAN DLTTALRRPI
2460 2470 2480 2490 2500
NATDRSHYYV DSVTVKETVV QFNYRRDGQP FYERFPLCAF TNLDKLKFKE
2510 2520 2530 2540 2550
VCKTTTGIPE YNFIIYDSSD RGQESLARSA CVYYSQVLCK SILLVDSSLV
2560 2570 2580 2590 2600
TSVGDSSEIA TKMFDSFVNS FVSLYNVTRD KLEKLISTAR DGVRRGDNFH
2610 2620 2630 2640 2650
SVLTTFIDAA RGPAGVESDV ETNEIVDSVQ YAHKHDIQIT NESYNNYVPS
2660 2670 2680 2690 2700
YVKPDSVSTS DLGSLIDCNA ASVNQIVLRN SNGACIWNAA AYMKLSDALK
2710 2720 2730 2740 2750
RQIRIACRKC NLAFRLTTSK LRANDNILSV RFTANKIVGG APTWFNALRD
2760 2770 2780 2790 2800
FTLKGYVLAT IIVFLCAVLM YLCLPTFSMV PVEFYEDRIL DFKVLDNGII
2810 2820 2830 2840 2850
RDVNPDDKCF ANKHRSFTQW YHEHVGGVYD NSITCPLTVA VIAGVAGARI
2860 2870 2880 2890 2900
PDVPTTLAWV NNQIIFFVSR VFANTGSVCY TPIDEIPYKS FSDSGCILPS
2910 2920 2930 2940 2950
ECTMFRDAEG RMTPYCHDPT VLPGAFAYSQ MRPHVRYDLY DGNMFIKFPE
2960 2970 2980 2990 3000
VVFESTLRIT RTLSTQYCRF GSCEYAQEGV CITTNGSWAI FNDHHLNRPG
3010 3020 3030 3040 3050
VYCGSDFIDI VRRLAVSLFQ PITYFQLTTS LVLGIGLCAF LTLLFYYINK
3060 3070 3080 3090 3100
VKRAFADYTQ CAVIAVVAAV LNSLCICFVA SIPLCIVPYT ALYYYATFYF
3110 3120 3130 3140 3150
TNEPAFIMHV SWYIMFGPIV PIWMTCVYTV AMCFRHFFWV LAYFSKKHVE
3160 3170 3180 3190 3200
VFTDGKLNCS FQDAASNIFV INKDTYAALR NSLTNDAYSR FLGLFNKYKY
3210 3220 3230 3240 3250
FSGAMETAAY REAAACHLAK ALQTYSETGS DLLYQPPNCS ITSGVLQSGL
3260 3270 3280 3290 3300
VKMSHPSGDV EACMVQVTCG SMTLNGLWLD NTVWCPRHVM CPADQLSDPN
3310 3320 3330 3340 3350
YDALLISMTN HSFSVQKHIG APANLRVVGH AMQGTLLKLT VDVANPSTPA
3360 3370 3380 3390 3400
YTFTTVKPGA AFSVLACYNG RPTGTFTVVM RPNYTIKGSF LCGSCGSVGY
3410 3420 3430 3440 3450
TKEGSVINFC YMHQMELANG THTGSAFDGT MYGAFMDKQV HQVQLTDKYC
3460 3470 3480 3490 3500
SVNVVAWLYA AILNGCAWFV KPNRTSVVSF NEWALANQFT EFVGTQSVDM
3510 3520 3530 3540 3550
LAVKTGVAIE QLLYAIQQLY TGFQGKQILG STMLEDEFTP EDVNMQIMGV
3560 3570 3580 3590 3600
VMQSGVRKVT YGTAHWLFAT LVSTYVIILQ ATKFTLWNYL FETIPTQLFP
3610 3620 3630 3640 3650
LLFVTMAFVM LLVKHKHTFL TLFLLPVAIC LTYANIVYEP TTPISSALIA
3660 3670 3680 3690 3700
VANWLAPTNA YMRTTHTDIG VYISMSLVLV IVVKRLYNPS LSNFALALCS
3710 3720 3730 3740 3750
GVMWLYTYSI GEASSPIAYL VFVTTLTSDY TITVFVTVNL AKVCTYAIFA
3760 3770 3780 3790 3800
YSPQLTLVFP EVKMILLLYT CLGFMCTCYF GVFSLLNLKL RAPMGVYDFK
3810 3820 3830 3840 3850
VSTQEFRFMT ANNLTAPRNS WEAMALNFKL IGIGGTPCIK VAAMQSKLTD
3860 3870 3880 3890 3900
LKCTSVVLLS VLQQLHLEAN SRAWAFCVKC HNDILAATDP SEAFEKFVSL
3910 3920 3930 3940 3950
FATLMTFSGN VDLDALASDI FDTPSVLQAT LSEFSHLATF AELEAAQKAY
3960 3970 3980 3990 4000
QEAMDSGDTS PQVLKALQKA VNIAKNAYEK DKAVARKLER MADQAMTSMY
4010 4020 4030 4040 4050
KQARAEDKKA KIVSAMQTML FGMIKKLDND VLNGIISNAR NGCIPLSVIP
4060 4070 4080 4090 4100
LCASNKLRVV IPDFTVWNQV VTYPSLNYAG ALWDITVINN VDNEIVKSSD
4110 4120 4130 4140 4150
VVDSNENLTW PLVLECTRAS TSAVKLQNNE IKPSGLKTMV VSAGQEQTNC
4160 4170 4180 4190 4200
NTSSLAYYEP VQGRKMLMAL LSDNAYLKWA RVEGKDGFVS VELQPPCKFL
4210 4220 4230 4240 4250
IAGPKGPEIR YLYFVKNLNN LHRGQVLGHI AATVRLQAGS NTEFASNSSV
4260 4270 4280 4290 4300
LSLVNFTVDP QKAYLDFVNA GGAPLTNCVK MLTPKTGTGI AISVKPESTA
4310 4320 4330 4340 4350
DQETYGGASV CLYCRAHIEH PDVSGVCKYK GKFVQIPAQC VRDPVGFCLS
4360 4370 4380 4390
NTPCNVCQYW IGYGCNCDSL RQAALPQSKD SNFLNESGVL L
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13305.1 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13305.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4R3D | X-ray | 2.82 | A/B | 1481-1811 | [»] | |
5DUS | X-ray | 1.43 | A | 1110-1273 | [»] | |
5HIH | X-ray | 1.66 | A | 1109-1275 | [»] | |
5WKJ | X-ray | 2.05 | A | 3248-3553 | [»] | |
5WKK | X-ray | 1.55 | A | 3248-3553 | [»] | |
5WKL | X-ray | 1.85 | A | 3248-3553 | [»] | |
5WKM | X-ray | 2.25 | A | 3248-3553 | [»] | |
SMRi | K9N638 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | K9N638, 1 interactor |
Proteomic databases
PRIDEi | K9N638 |
Family and domain databases
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.1190, 1 hit 1.10.8.370, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.10.20.350, 1 hit 3.10.20.540, 1 hit 3.40.220.10, 1 hit 3.40.220.20, 1 hit 3.40.50.11020, 1 hit 3.90.70.90, 1 hit |
InterProi | View protein in InterPro IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR002589, Macro_dom IPR043472, Macro_dom-like IPR042570, NAR_sf IPR036333, NSP10_sf_CoV IPR021590, NSP1_bCoV IPR024375, NSP3_bCoV IPR032592, NSP3_NAR_bCoV IPR038400, NSP3_SUD-M_sf_bCoV IPR038083, NSP3A-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043177, PLpro_N_sf_CoV IPR043503, PLpro_palm_finger_dom_CoV IPR043178, PLpro_thumb_sf_CoV IPR018995, RNA_synth_NSP10_CoV |
Pfami | View protein in Pfam PF16251, bCoV_NAR, 1 hit PF11501, bCoV_NSP1, 1 hit PF11633, bCoV_SUD_M, 1 hit PF09401, CoV_NSP10, 1 hit PF19212, CoV_NSP2_C, 1 hit PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 1 hit SSF159936, SSF159936, 1 hit SSF50494, SSF50494, 1 hit SSF52949, SSF52949, 1 hit |
PROSITEi | View protein in PROSITE PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1A_MERS1 | |
Accessioni | K9N638Primary (citable) accession number: K9N638 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2013 |
Last sequence update: | March 6, 2013 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families