UniProtKB - K9N4V0 (ORF4A_MERS1)
Protein
Non-structural protein ORF4a
Gene
ORF4a
Organism
Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1)
Status
Functioni
DsRNA-binding protein that plays a role in the inhibition of host innate response. Suppresses host PACT-induced activation of DDX58 and MDA5 and thereby circumvents the production of type I inteferons. Prevents also the activation of host NF-kappaB.3 Publications
GO - Biological processi
- modulation by virus of host apoptotic process Source: UniProtKB-KW
- modulation by virus of host G0/G1 transition checkpoint Source: UniProtKB-KW
- suppression by virus of host innate immune response Source: UniProtKB-KW
- suppression by virus of host NF-kappaB transcription factor activity Source: UniProtKB
- suppression by virus of host type I interferon production Source: UniProtKB
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural protein ORF4aShort name: ORF4a |
Gene namesi | Name:ORF4a |
Organismi | Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) (MERS-CoV) (Betacoronavirus England 1) |
Taxonomic identifieri | 1263720 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Merbecovirus › |
Virus hosti | Camelus dromedarius (Dromedary) (Arabian camel) [TaxID: 9838] Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host cytoplasm 1 Publication
GO - Cellular componenti
- host cell cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Host cytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000422436 | 1 – 109 | Non-structural protein ORF4aAdd BLAST | 109 |
Interactioni
Subunit structurei
Interacts with host PRKRA/PACT.
1 PublicationProtein-protein interaction databases
IntActi | K9N4V0, 48 interactors |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 102 – 105 | Poly-GluSequence analysis | 4 |
i Sequence
Sequence statusi: Complete.
K9N4V0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYVSLLNQI WQKYLNSPYT TCLYIPKPTA KYTPLVGTSL HPVLWNCQLS
60 70 80 90 100
FAGYTESAVN STKALAKQDA AQRIAWLLHK DGGIPDGCSL YLRHSSLFAQ
SEEEESFSN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13309.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KC164505 Genomic RNA Translation: AFY13309.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | K9N4V0, 48 interactors |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ORF4A_MERS1 | |
Accessioni | K9N4V0Primary (citable) accession number: K9N4V0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2013 |
Last sequence update: | March 6, 2013 | |
Last modified: | February 10, 2021 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |