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Entry version 30 (29 Sep 2021)
Sequence version 1 (06 Mar 2013)
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Protein

Methylcytosine dioxygenase tet3-B

Gene

tet3-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. Conversion of 5mC into 5hmC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes, including pax6, rax, sox9 and six3. May also contribute to the regulation of target genes in ways that do not require its enzyme activity.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi68Zinc 1PROSITE-ProRule annotation1
Metal bindingi71Zinc 1PROSITE-ProRule annotation1
Metal bindingi74Zinc 1PROSITE-ProRule annotation1
Metal bindingi80Zinc 2PROSITE-ProRule annotation1
Metal bindingi83Zinc 2PROSITE-ProRule annotation1
Metal bindingi86Zinc 2PROSITE-ProRule annotation1
Metal bindingi96Zinc 2PROSITE-ProRule annotation1
Metal bindingi101Zinc 1PROSITE-ProRule annotation1
Metal bindingi974Zinc 3By similarity1
Metal bindingi976Zinc 3By similarity1
Metal bindingi1034Zinc 4By similarity1
Metal bindingi1060Zinc 1; via pros nitrogenBy similarity1
Metal bindingi1062Zinc 3By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei11022-oxoglutarateBy similarity1
Metal bindingi1112Zinc 4By similarity1
Metal bindingi1114Zinc 4By similarity1
Metal bindingi1130Zinc 3By similarity1
Metal bindingi1139Zinc 3By similarity1
Metal bindingi1199Zinc 3By similarity1
Binding sitei12152-oxoglutarateBy similarity1
Metal bindingi1221Zinc 2; via tele nitrogenBy similarity1
Metal bindingi1223Iron; catalyticBy similarity1
Metal bindingi1225Iron; catalyticBy similarity1
Binding sitei12572-oxoglutarateBy similarity1
Metal bindingi1794Iron; catalyticBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri61 – 102CXXC-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, Dioxygenase, DNA-binding, Oxidoreductase
LigandIron, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methylcytosine dioxygenase tet3-B (EC:1.14.11.n21 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tet3-bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Morpholino knockdown of both tet3-a and tet3-b causes defects in embryonic development, including malformations of the eye (eyeless), small head, and missing pigmentation along the lateral body, leading to embryonic death between stages 35 and 40.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004423161 – 1915Methylcytosine dioxygenase tet3-BAdd BLAST1915

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryo (at protein level). Detected in embryonic head, in developing brain and eye.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression in oocytes is very low. Barely detectable from stage 2 (2-cell stage) to stage 9. Increases strongly from stage 9 to 17, and decreases again at stage 25.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
K9JHZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 49DisorderedSequence analysisAdd BLAST22
Regioni629 – 679DisorderedSequence analysisAdd BLAST51
Regioni776 – 806DisorderedSequence analysisAdd BLAST31
Regioni831 – 880DisorderedSequence analysisAdd BLAST50
Regioni1298 – 1356DisorderedSequence analysisAdd BLAST59
Regioni1469 – 1516DisorderedSequence analysisAdd BLAST48
Regioni1719 – 1753DisorderedSequence analysisAdd BLAST35
Regioni1809 – 18112-oxoglutarate bindingBy similarity3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1827 – 1860Sequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi640 – 675Basic and acidic residuesSequence analysisAdd BLAST36
Compositional biasi835 – 880Polar residuesSequence analysisAdd BLAST46
Compositional biasi1298 – 1338Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi1339 – 1356Polar residuesSequence analysisAdd BLAST18
Compositional biasi1469 – 1507Polar residuesSequence analysisAdd BLAST39
Compositional biasi1719 – 1736Polar residuesSequence analysisAdd BLAST18
Compositional biasi1737 – 1753Basic and acidic residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds target DNA that contains at least one unmethylated cytosine via the CXXC-type zinc-finger domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri61 – 102CXXC-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3
IPR002857, Znf_CXXC

The PANTHER Classification System

More...
PANTHERi
PTHR23358, PTHR23358, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12851, Tet_JBP, 1 hit
PF02008, zf-CXXC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01333, Tet_JBP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058, ZF_CXXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K9JHZ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METQPASVPC VLPQDVYEFS EDRESLGRLR VSEMPSELNG GGDGSKGDGA
60 70 80 90 100
AVVATEVSQQ SNKKRKRCGV CVPCLRKEPC GTCYNCVNRS TSHQICKMRK
110 120 130 140 150
CEQLKKKRVV PMKGVEAVDK DDAKNQAKEQ VPSVKNCSES ILVDGPKTDQ
160 170 180 190 200
MEAGPVNHVQ EGRLKQECDS TLPSKGSEDL ANQLLMEANS WLSNTAAPQD
210 220 230 240 250
PCNKLNWDKP IIPNHIAANN NSNLEDAKNL VAFSAVAEAM SNYGMPASGT
260 270 280 290 300
PSSISMQLYE KFNYETNQDN SGHSEGNAPS CPEDLNTLKE ALALAKHGVK
310 320 330 340 350
PPNCNCDGPE CPDYLEWLEN KIKSTGKGSQ ESPFPSLGQV SKKLVQKSYH
360 370 380 390 400
KEQVLNLENT NVTCPSGNLP FSQNALSLAK EKNISLQTAI AIEALTQLSS
410 420 430 440 450
ALPQTNNEYP NAPSQPLINH NDQLTHFPTA KGNQLPMLPL SCNELFQNQQ
460 470 480 490 500
AQLYTGKNAL PVPQSPRQAS WEQNKKPGYQ ESEYIPENLS QSSSVLPSDA
510 520 530 540 550
STPQKKEFLQ QWVQNADLLK SPSDPMTGLK QLLGNTDEYI KSAFKGPEGL
560 570 580 590 600
SKKIKNVKSK HTIKSIKKES ADFTKMSPDQ QLSQLLQGND FHRNTQAALQ
610 620 630 640 650
QHLHHKRNLF VDSNTMEACT QEQQNWWVPN SQQAPVSKTT EKPVKERKKR
660 670 680 690 700
RQSPSQKQVE PKPKPPRKQV QIKKPRVKEG NAVFMPVSQI SLDSFRRVEK
710 720 730 740 750
EENQVKELDL ENSLPINVQP DLLGSQSIQL TGSQANLENQ KTVNTQETCN
760 770 780 790 800
ENQTSIGKAN NFALCVNKTN SLVAKGRCPT PSTGDSSSGQ GDSANQHTNL
810 820 830 840 850
TDVPGQNDLS CIDDKFEDLI KQFAAEFGED FSLPGSEVPS QNGERPPKQQ
860 870 880 890 900
TSGVPQFKMP FPSQLPSENA THSNPALSNN LLTHNASHKF DSLFSSKSPK
910 920 930 940 950
QIKIESSGAI TVVSTTCSYS EENQHLDGTP TKSELPFNPT LSGFLESPLK
960 970 980 990 1000
YLTSPTKSLI DTPAKMAQAE FPTCDCVEQI NEKDEGPYYT HLGSGPTVAS
1010 1020 1030 1040 1050
IRELMEERFG EKGEAIRIEK VIYTGKEGKS SRGCPIAKWV IRRQSEDEKL
1060 1070 1080 1090 1100
MCLVRQRAGH HCENAVIIIL IMAWEGIPRA LGDSLYDDIS GTITKYGNPT
1110 1120 1130 1140 1150
SRRCGLNDDR TCACQGKDPN TCGASFSFGC SWSMYFNGCK YARSKTPRKF
1160 1170 1180 1190 1200
RLIGDNPKEE EFLKDSFQDL ATKVAPVYKM LAPQAYQNQA NNEDVAIDCR
1210 1220 1230 1240 1250
LGLEEGRPFS GVTACMDFCA HAHKDQHNLY NGCTVVCTLT KEDNRMIGKI
1260 1270 1280 1290 1300
AEDEQLHVLP LYKVSTTDEF GSEERQLEKI RKGGIQVLSS FPREVRKLSE
1310 1320 1330 1340 1350
PAKSCRQRQL DAKKATAEKK KLQKEKLVSP DKTKQEPSDT KTCQQNPGVP
1360 1370 1380 1390 1400
QQQTKPCVKV EPSNHYNTFK YNGNGVVESY SVLGSCRPSD PYSMNSVYSY
1410 1420 1430 1440 1450
HSFYAQPNLP SVNGFHSKFA LPPFGFYSFP NNPVVPNQFM NYGTGDARNS
1460 1470 1480 1490 1500
GWMNNSFEKK PELQSLADGM NQSYGSELPE QNYRRSSEVP HHYSLQNSNS
1510 1520 1530 1540 1550
QKSVGVPHRT TPAPMETTPY SNVPCYNKVI KKEPVCDPLV DPFQRSNSVH
1560 1570 1580 1590 1600
SQSPGVNHSL QTNDLSYKAN GALPSSGRTN KEGPCSMFLP SDKNGLEKRD
1610 1620 1630 1640 1650
YFGVHSNVPG LKEKQWTPYG IDVPVGQRDS LDSQCSGKVW SSCKLSDSPA
1660 1670 1680 1690 1700
VMPSTVQDKN WTGRQASLNQ GVKEPMPFQE KLWNSVAASG RCSTTPNDRS
1710 1720 1730 1740 1750
SVTPCAELQD KNWMSFPNPA VNSLKTDSSQ NHWDPYSLDD NMDDGQSKSV
1760 1770 1780 1790 1800
KEEEDEEEIW SDSEHNFLDG NIGGVAVAPG HGSILIECAR RELHATTPLK
1810 1820 1830 1840 1850
KPNRCHPTRI SLVFYQHKNL NQPNHGLALW EAKMKQLAER ARVKEEEAAK
1860 1870 1880 1890 1900
LGIKQEVKSL GKKRKWGGAA TTETPPVEKK DFIPTRQAAT SLTDSTTTAF
1910
SYAYTKVTGP YSRFI
Length:1,915
Mass (Da):212,099
Last modified:March 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49CC646926FBE86C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
HQ220208 mRNA Translation: ADU77106.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ220208 mRNA Translation: ADU77106.1

3D structure databases

SMRiK9JHZ4
ModBaseiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR024779, 2OGFeDO_noxygenase_dom
IPR040175, TET1/2/3
IPR002857, Znf_CXXC
PANTHERiPTHR23358, PTHR23358, 1 hit
PfamiView protein in Pfam
PF12851, Tet_JBP, 1 hit
PF02008, zf-CXXC, 1 hit
SMARTiView protein in SMART
SM01333, Tet_JBP, 1 hit
PROSITEiView protein in PROSITE
PS51058, ZF_CXXC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTET3B_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K9JHZ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: March 6, 2013
Last modified: September 29, 2021
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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