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Entry version 56 (13 Feb 2019)
Sequence version 1 (06 Feb 2013)
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Protein
Submitted name:

ATP-binding cassette subfamily C member 1

Gene

abcc1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi673 – 680ATPPROSITE-ProRule annotation8
Nucleotide bindingi1308 – 1315ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: GO_Central
  • ATP binding Source: UniProtKB-UniRule

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-XTR-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-XTR-382556 ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATP-binding cassette subfamily C member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:abcc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-960171 abcc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 54HelicalSequence analysisAdd BLAST20
Transmembranei74 – 92HelicalSequence analysisAdd BLAST19
Transmembranei104 – 122HelicalSequence analysisAdd BLAST19
Transmembranei134 – 153HelicalSequence analysisAdd BLAST20
Transmembranei173 – 189HelicalSequence analysisAdd BLAST17
Transmembranei323 – 342HelicalSequence analysisAdd BLAST20
Transmembranei362 – 384HelicalSequence analysisAdd BLAST23
Transmembranei436 – 458HelicalSequence analysisAdd BLAST23
Transmembranei464 – 492HelicalSequence analysisAdd BLAST29
Transmembranei542 – 570HelicalSequence analysisAdd BLAST29
Transmembranei582 – 606HelicalSequence analysisAdd BLAST25
Transmembranei1078 – 1109HelicalSequence analysisAdd BLAST32
Transmembranei1180 – 1201HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
K9J8B4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000019661 Expressed in 11 organ(s), highest expression level in egg cell

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000042600

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini325 – 607ABC transmembrane type-1InterPro annotationAdd BLAST283
Domaini639 – 863ABC transporterInterPro annotationAdd BLAST225
Domaini1005 – 1237ABC transmembrane type-1InterPro annotationAdd BLAST233
Domaini1276 – 1508ABC transporterInterPro annotationAdd BLAST233

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054 Eukaryota
COG1132 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160271

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K9J8B4

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEWRVDA

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957 MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K9J8B4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESFCSYDGS ERFWDSNLTW YTENPDFTKC FQNTVLIWIP CIYLWFCLPF
60 70 80 90 100
YFAYLRKNDQ GYIQMSHLNK AKTAIGFILW LACWADLFYS FWERSQSIYR
110 120 130 140 150
APVYVVSPTV LGITMLLATF LIQYERIKGV QSSGVMLNFW IVALLCAIII
160 170 180 190 200
FRSKVLHALK PDAQIDVFRD TTFYIYFLLV LVELILSAFP DRPPLFSERV
210 220 230 240 250
NDPNPCPESS ASFLSQITFW WISRMMVQGF KRPLEAKDLW SLNKEDKSLE
260 270 280 290 300
VVPVLSKNWE KEYNKAKAKK VPLKMVYSPK KQTKKLNSKE DVREEAEALI
310 320 330 340 350
VKPAPKELEP SLLKALYKTF GPYFFISCFF KFFHDVLMFS GPQLLQLLIK
360 370 380 390 400
FVGDKDAPDW HGYLYTFLLF FCACLQTLIL HKYFHICFVT GMRLKTAVVG
410 420 430 440 450
LVYRKALVIN NSARRTSTIG EIVNLMSVDA QRFMDLATYI NMIWSAPLQV
460 470 480 490 500
ILAFYLLWQN VGPSVLAGIA VMVVMLMLVA PCIFSAAVTS VVQMKCKDNR
510 520 530 540 550
IKLMNEILNG IKVLKLYAWE LAFKEKVLGI RKDELKVLKK SAYLAAVGTF
560 570 580 590 600
TWVCAPFLVA LSTFAVYVLI DKQNVLDAEK AFVSLALFNI LRFPLNMLPM
610 620 630 640 650
VISSMVQASV SLKRLRVFLS HEELEPESII REPQKSSGMH NGDSIKVDVF
660 670 680 690 700
LRASTYHIIN ISIPEGSLVA VVGQVGCGKS SLLSALLGEM EKQDGYVAMK
710 720 730 740 750
GSVGYVSQQA WIQNASLKDN VLFGRESNES MYKKVIEACA LLPDLEILPT
760 770 780 790 800
GDRTEIGEKG VNLSGGQKQR VSLARAVYCN TDIYLLDDPL SAVDAHVGKH
810 820 830 840 850
IFDKVIGPKG MLKNKTRILV THGVSYLPQM DSIIVMVDGK ITEVGSYQDL
860 870 880 890 900
LMQDGAFAEF LRTYANAEQN KDQEVESGTC PIEAPSPVPS EEKRLENGIL
910 920 930 940 950
RNERNLQRQL SASSETKSLN QNKTGDLNSS EKDDWKLTEA DKAKTGRVSY
960 970 980 990 1000
TFYYYYDPLL WMKTTFTENE QFLSGSYGLL QTNTAGPDHS EANEAEGNVC
1010 1020 1030 1040 1050
HFLPIVGIAV YGYSTAVSLG GILASRFLHT DLLHNVLRFP MSFFERTPSG
1060 1070 1080 1090 1100
NLVNRFSKEI DTIDNTIPQI IKMFMGSLFN VIGACVIILT ATPIVAVIIP
1110 1120 1130 1140 1150
PLGLVYFFVQ RFYVATSRQL KRLESVSRSP VYSHFNETLL GSSVIRAFGE
1160 1170 1180 1190 1200
QKRFIQISDF KVDENQRAYY PSIVSNSRWL AIRLEFVGNC IVLFASLFAV
1210 1220 1230 1240 1250
ISRTTLSPGL VGLSVSYALQ VTTYLNWLVR MSSELETNIV AVERVKEYAD
1260 1270 1280 1290 1300
LKQEAAWTVQ ETAPEATWPH EGKIEFRGYG LRYREDLDLA LKNINVTIQG
1310 1320 1330 1340 1350
GEKVGIVGRT GAGKSSLTLG LFRINEAAAG EIVIDGCNLA KIGLHDLRFR
1360 1370 1380 1390 1400
VTIIPQDPVL FSGTLRMNLD PFDKYTDDDI WTSLELAHLK RFVANLPDRL
1410 1420 1430 1440 1450
NHECAEGGEN LSIGQRQLVC LARALLRKTK ILVLDEATAA VDLETDGLIQ
1460 1470 1480 1490 1500
STIRKEFQDC TVITIAHRLN TIMDYTKVIV LDKGQVVEFD SPSNLLQQQG
1510
IFFNMAKDSG LV
Length:1,512
Mass (Da):170,422
Last modified:February 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E9E2963B3A49286
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAMC01009816 Genomic DNA No translation available.
AAMC01009817 Genomic DNA No translation available.
AAMC01009818 Genomic DNA No translation available.
AAMC01009819 Genomic DNA No translation available.
AAMC01009820 Genomic DNA No translation available.
AAMC01009821 Genomic DNA No translation available.
AAMC01009822 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000042600; ENSXETP00000042600; ENSXETG00000019661

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01009816 Genomic DNA No translation available.
AAMC01009817 Genomic DNA No translation available.
AAMC01009818 Genomic DNA No translation available.
AAMC01009819 Genomic DNA No translation available.
AAMC01009820 Genomic DNA No translation available.
AAMC01009821 Genomic DNA No translation available.
AAMC01009822 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000042600

Proteomic databases

PaxDbiK9J8B4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000042600; ENSXETP00000042600; ENSXETG00000019661

Organism-specific databases

XenbaseiXB-GENE-960171 abcc1

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00940000160271
InParanoidiK9J8B4
OMAiNEWRVDA
TreeFamiTF105199

Enzyme and pathway databases

ReactomeiR-XTR-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
R-XTR-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-XTR-382556 ABC-family proteins mediated transport

Gene expression databases

BgeeiENSXETG00000019661 Expressed in 11 organ(s), highest expression level in egg cell

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK9J8B4_XENTR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K9J8B4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2013
Last sequence update: February 6, 2013
Last modified: February 13, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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