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Entry version 55 (07 Apr 2021)
Sequence version 3 (02 Dec 2020)
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Protein

Sodium channel protein

Gene

cdknx

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-5576892, Phase 0 - rapid depolarisation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdknxImported
Synonyms:scn2aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1032978, cdknx
XB-GENE-6447552, scn2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei219 – 239HelicalUniRule annotationAdd BLAST21
Transmembranei335 – 362HelicalUniRule annotationAdd BLAST28
Transmembranei683 – 701HelicalUniRule annotationAdd BLAST19
Transmembranei752 – 775HelicalUniRule annotationAdd BLAST24
Transmembranei796 – 821HelicalUniRule annotationAdd BLAST26
Transmembranei883 – 906HelicalUniRule annotationAdd BLAST24
Transmembranei1135 – 1153HelicalUniRule annotationAdd BLAST19
Transmembranei1174 – 1193HelicalUniRule annotationAdd BLAST20
Transmembranei1205 – 1228HelicalUniRule annotationAdd BLAST24
Transmembranei1249 – 1277HelicalUniRule annotationAdd BLAST29
Transmembranei1376 – 1399HelicalUniRule annotationAdd BLAST24
Transmembranei1458 – 1476HelicalUniRule annotationAdd BLAST19
Transmembranei1488 – 1506HelicalUniRule annotationAdd BLAST19
Transmembranei1518 – 1538HelicalUniRule annotationAdd BLAST21
Transmembranei1575 – 1603HelicalUniRule annotationAdd BLAST29
Transmembranei1677 – 1702HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
K9J7Z6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSXETG00000021004, Expressed in trigeminal nerve and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000019636

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 368Ion_transInterPro annotationAdd BLAST238
Domaini448 – 632Na_trans_cytoplInterPro annotationAdd BLAST185
Domaini683 – 911Ion_transInterPro annotationAdd BLAST229
Domaini920 – 1128Na_trans_assocInterPro annotationAdd BLAST209
Domaini1133 – 1407Ion_transInterPro annotationAdd BLAST275
Domaini1457 – 1712Ion_transInterPro annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 54DisorderedSequence analysisAdd BLAST29
Regioni435 – 462DisorderedSequence analysisAdd BLAST28
Regioni516 – 557DisorderedSequence analysisAdd BLAST42
Regioni1031 – 1066DisorderedSequence analysisAdd BLAST36
Regioni1872 – 1924DisorderedSequence analysisAdd BLAST53

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili359 – 396Sequence analysisAdd BLAST38
Coiled coili624 – 644Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 51PolyampholyteSequence analysisAdd BLAST26
Compositional biasi442 – 462PolyampholyteSequence analysisAdd BLAST21
Compositional biasi516 – 543PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1873 – 1899PolarSequence analysisAdd BLAST27
Compositional biasi1900 – 1924PolyampholyteSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163423

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000540_5_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K9J7Z6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KGIFCWE

TreeFam database of animal gene trees

More...
TreeFami
TF323985

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

K9J7Z6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRIVPPGP DSFRYFTRES LKAIEKRISE EKENNAKQEQ KEGEENGPKP
60 70 80 90 100
NRDLEAGQSL PFIYGDIPPR MVSEPLEDLD PYYANQKTFI VLNKGKTLFR
110 120 130 140 150
FSATSALYIL TPFNPVRQAA IKILVHSYPL QFLPLKWTKN VEYTFTGIYT
160 170 180 190 200
LESLIKILAR GFCLEKFTFL RDPWNWLDFS VIVLAATFRL LHFTYKEAFF
210 220 230 240 250
SLKTIVGALI QSVKKLSDVM ILTVFCLSVF ALIGLQLFMG HLRNKCLLWP
260 270 280 290 300
YNSSVDISLF YKLENQKDPL VCGNSSDTGK CPEGYVCVKA GRNPNYGYTS
310 320 330 340 350
FDTFNWAFLS LFRLMTQDCW ENLYQLTLRA AGKTYMIFFV LVIFLGSFYL
360 370 380 390 400
VNLILAVVAM AYEEQNQATI EEAVQKEAEF QRLKKQQEEA QALAAAVADV
410 420 430 440 450
FGESQELSEE VGLEDASECS STVSKLSSKS AKERRNWRKQ RKQVAHCDGQ
460 470 480 490 500
EKGDKEKCYK SGSEDSIKRK GLNFTREGRR LEEYRKSSII QGPVFSPRRN
510 520 530 540 550
SKTSIFSFKD RAKDVGSEND FADDERSTFE EDSRRDPLFV PGRHRARRNS
560 570 580 590 600
NISQTSRSSR ILPLLSMNGK MHSTVDCNGV VSLVGGSSAP IGLFPEGTTT
610 620 630 640 650
ETDRKRRPSS YKISMDLMED PSLRQRAQSI ASILTNTMEE LQESRRKCPS
660 670 680 690 700
CWYKFANCFL IWDCCEAWLK VKRIVKLIVM DPFVDLAITI SIVLNTIFMA
710 720 730 740 750
VEHAHMTPYF ISVLTTGNQV FTGIFTAEMV LKLIALDPYY YFQEGWNIFD
760 770 780 790 800
GLIVSLSLME LGLSSTGGFS VLRSFRLLRV FKLAKSWPTL NKLIKIIGNS
810 820 830 840 850
VGALGNLTLV LAIIVFIFAV VGMQLFGKSY KECVCKIAEN CELPRWHMND
860 870 880 890 900
FFHSFLIVFR VLCGEWIETM WDCMEVAGQS MCLLVFMLVM VIGNLVVLNL
910 920 930 940 950
FLALLLSSFS SDNLSATDED SEINNIQIAV GRIQRGVASG KIILREFFEK
960 970 980 990 1000
LFLQKQKDIN ETKQLEETPG KNDTCVLGNA VVEILKEKND VRDSDGMTSE
1010 1020 1030 1040 1050
IGSSVEKSAE NEKEYMTVIN KTSLTVAVPI APGESDFENP NTEEFSSESD
1060 1070 1080 1090 1100
PEETKEKIKV SSSSEGSTID IRAPGVERIE EFLDYEYEET FDPEPCFTDD
1110 1120 1130 1140 1150
CVASFTCCQI NIENGTGRDW WNLRKTCYTI VEHSWFESFI IFMILLSSGA
1160 1170 1180 1190 1200
LAFEDIYVEQ RRNVKAILEY ADKVFAYIFI MEMLLKWVAY GFIKYFTNAW
1210 1220 1230 1240 1250
CWLDFIIVDI SLVSLIANAL GYSELGAIKS LRTLRALRPL RALSRFEGMR
1260 1270 1280 1290 1300
VVVNALIGAI PSIMNVLLVC LIFWLIFSIM GVNLFAGKFY YCVNTTSGVP
1310 1320 1330 1340 1350
FPATDVNNYS DCRMYINTTG AARWKNVKVN FDNVGAGYLA LLQVATFKGW
1360 1370 1380 1390 1400
MPIMYAAVDS REINEQPKYE NNTTMYLYFV AFIIFGSFFT LNLFIGVIID
1410 1420 1430 1440 1450
NFNQQKKKIR GQDIFMTEEQ KKYYNAMKKL GSKKPQKPIP RPANCCQGLI
1460 1470 1480 1490 1500
FDFVTKQAFD IIIMILIFLN MVTMMIETDD QSQEMEMYLY RINAVFIILF
1510 1520 1530 1540 1550
TGEFLLKLIS LRQYYFTIGW NIFDLVVVIL SIVGMFLADI IERYFFSPTL
1560 1570 1580 1590 1600
FRVIRLARIG RILRLIKAAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY
1610 1620 1630 1640 1650
AIFGMSNFAY VKKQSGIDDM FNFETFGNSM ICLFQITTSA GWDLLLEPIL
1660 1670 1680 1690 1700
NSGEPDCDPN AEHPGSLFKG DCGNPSVGIF FFVSYIIISF LIVVNMYIAV
1710 1720 1730 1740 1750
ILENFSVATE ESAEPLGEDD FEMFYEVWEK FDPSASQFIE YSKLSDFADA
1760 1770 1780 1790 1800
LDPPLRVPKP NNIQLIAMDL PMVSGDRIHC LDILFAFTKR VLGEGGEMDS
1810 1820 1830 1840 1850
LRQPMEERFM TSNPSKVPYE PITTTLRRKQ EEQSAVVIQR CYRRFRLKKR
1860 1870 1880 1890 1900
QASQTYKGNR NKQIEEIERN VNKSQQRYTT EISDTSTSTM SPPSYDSVEK
1910 1920
TQQEKYEKDR QKKKISLKTQ NDVH
Length:1,924
Mass (Da):219,678
Last modified:December 2, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02AAC57283F022F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6I8QER8A0A6I8QER8_XENTR
Sodium channel protein
scn2a
1,875Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8QP97A0A6I8QP97_XENTR
Sodium channel protein
scn2a
1,944Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8QQ01A0A6I8QQ01_XENTR
Sodium channel protein
scn2a
1,915Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8QW83A0A6I8QW83_XENTR
Sodium channel protein
scn2a
1,958Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8RHB6A0A6I8RHB6_XENTR
Sodium channel protein
scn2a
1,815Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8RIV2A0A6I8RIV2_XENTR
Sodium channel protein
scn2a
1,962Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8SBC2A0A6I8SBC2_XENTR
Sodium channel protein
scn2a
1,947Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8SY41A0A6I8SY41_XENTR
Sodium channel protein
scn2a
1,969Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8T2N0A0A6I8T2N0_XENTR
Sodium channel protein
scn2a
1,964Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6TGL4F6TGL4_XENTR
Cyclin-dependent kinase inhibitor x...
cdknx
207Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_002934672.1, XM_002934626.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSXETT00000019636; ENSXETP00000019636; ENSXETG00000021004

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100126686

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:100126686

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_002934672.1, XM_002934626.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000019636

Proteomic databases

PaxDbiK9J7Z6

Genome annotation databases

EnsembliENSXETT00000019636; ENSXETP00000019636; ENSXETG00000021004
GeneIDi100126686
KEGGixtr:100126686

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
100126686
XenbaseiXB-GENE-1032978, cdknx
XB-GENE-6447552, scn2a

Phylogenomic databases

eggNOGiKOG2301, Eukaryota
GeneTreeiENSGT00940000163423
HOGENOMiCLU_000540_5_2_1
InParanoidiK9J7Z6
OMAiKGIFCWE
TreeFamiTF323985

Enzyme and pathway databases

ReactomeiR-XTR-5576892, Phase 0 - rapid depolarisation

Gene expression databases

BgeeiENSXETG00000021004, Expressed in trigeminal nerve and 6 other tissues

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 2 hits
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit
PRINTSiPR00170, NACHANNEL

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK9J7Z6_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K9J7Z6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2013
Last sequence update: December 2, 2020
Last modified: April 7, 2021
This is version 55 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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