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Entry version 47 (08 May 2019)
Sequence version 1 (06 Feb 2013)
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Protein

Carboxypeptidase

Gene

CELE_Y16B4A.2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • serine-type carboxypeptidase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseUniRule annotationSAAS annotationImported, Hydrolase, Protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-2132295 MHC class II antigen presentation
R-CEL-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S10.A57

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CarboxypeptidaseUniRule annotation (EC:3.4.16.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CELE_Y16B4A.2Imported, Y16B4A.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
Y16B4A.2 ; CE48023 ; WBGene00012445

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21UniRule annotationAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500513849622 – 2161CarboxypeptidaseUniRule annotationAdd BLAST2140

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
K8ESM2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
K8ESM2

PeptideAtlas

More...
PeptideAtlasi
K8ESM2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00012445 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.Y16B4A.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
K8ESM2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S10 family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1282 Eukaryota
COG2939 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K8ESM2

KEGG Orthology (KO)

More...
KOi
K13289

Identification of Orthologs from Complete Genome Data

More...
OMAi
DPYNMYQ

Database of Orthologous Groups

More...
OrthoDBi
607679at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS

The PANTHER Classification System

More...
PANTHERi
PTHR11802 PTHR11802, 12 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00450 Peptidase_S10, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00724 CRBOXYPTASEC

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 4 hits
PS00131 CARBOXYPEPT_SER_SER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K8ESM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAHQILLLC LLLLLAPLRN GQTTPTTRAQ ADLVNQLPGT IFQVNFKQYA
60 70 80 90 100
GYLNSDPNKN YNNLHYWLIE SQLTPSNDTL LLWINGGPGC SSVFGQIQEI
110 120 130 140 150
GPFHVSSDSQ TVYENVFAWN KVSNLLAIDG PGAGFSWQQN LFQDDSYVTG
160 170 180 190 200
ALLNALMDFY TVYPNMLNSD LYIAGEGYGS FFASSLVESL MVNNTPRPDI
210 220 230 240 250
VTSPVNIRGL LLANGDLSAR LQYNSLIPFY YTHGFAGSKQ YDDLKSVCCT
260 270 280 290 300
NASTQTCDFF NSNTACRTKA DNAIATWSNY QIDNTNINED CYRNQAAWQT
310 320 330 340 350
SFKQLGINAA VDNYNSTDSF RGYPCFALSA TAAYLNRQDV QAALHVSVNA
360 370 380 390 400
STNFQTCRNL TYGELSTDLQ IRISSILTSE KYAQNNMKIM IYNGDLDLWS
410 420 430 440 450
NFIGAQRFGQ EIAAALKLNT TEDRIWRHNY DSAAFVWMDG GVITSYSSNF
460 470 480 490 500
HIASIRGGGH FAPQNRPSQS LQLYRDFVLG LFFNNCLSRV NKVAAPLLPA
510 520 530 540 550
YQQLAAPATR RDADKIVNLP GLTYQINFNQ YSGYLNASDT HRFHYWFVES
560 570 580 590 600
QNDPTNSPVL LWLNGGPGSS SLWGMLTENG PFRPNKDGQT LYENVHSWNK
610 620 630 640 650
FANVLYLESP HQVGYSYSTV ANDYTYGDDL TASDNYNALK DFFNNIFPQY
660 670 680 690 700
KQNPFYITGE SYGGVYIPTL SKLLLQMLSA GEININFKGI AIGNGELTTK
710 720 730 740 750
LQVNSAIFQL YTYGLFGENE YNALVARCCK NVTDPTQCDF YTPYVFFDYL
760 770 780 790 800
GNYKAVDGAD PFCSSTILGV VNDQVWNSAN NPYNIYGDCY TTSASSSSSS
810 820 830 840 850
SSKSNKQNRA AVRDNAGLLN LASSDPFDGF PCWSTDATTT YLNRDDVRNA
860 870 880 890 900
LHIPTTVQQW QSFNQTVNAQ LYNRSYFELD AVLNRILSSY YYKQNNMKIL
910 920 930 940 950
IYNGDVDMVC NHLGDQWLIE QVASNAGLKT VSPRQPWNYV MAGQNYLPQL
960 970 980 990 1000
AGYVKVFDSN LNLVTVKGSG HLVPQDRPGP ALQMIFNFIS GVNLNTTFPY
1010 1020 1030 1040 1050
ALPAAPLLPA YSDLQGCQAP QYPTAQSLPT LPPLPPLPPG VTYPFVAKKD
1060 1070 1080 1090 1100
VVEVAEPGTI AADEHGSQIY PTALNDAAKA DMILSLPGLT FNVTYRMFSG
1110 1120 1130 1140 1150
YLTADETPLN HLFYWFVESQ NDPVNDPVVL WLNGGPGCSS LGGFFTELGP
1160 1170 1180 1190 1200
FHPNDDGGQT LYENVFSWNK KANVIFLEAP AKVGFSYTED PNYYWDDDTT
1210 1220 1230 1240 1250
AQNNGYAIKS FFQKKFPQYA QNQFFITGES YGGVYCPTLT LNLVQQIDAG
1260 1270 1280 1290 1300
ILNLNFKGTA VGNGILSEYL QTNSEIVLQY GRGFNGVDDW NNLKTACNLT
1310 1320 1330 1340 1350
NSDTIYYDYQ GAPEGSACYQ AVDDNQKKFY GLDERYGDPY NMYQDCYLYN
1360 1370 1380 1390 1400
NKGAWQTPSA QQQTKPKTRR ERALRAHMNR RKSFASASIK FDNSNSKNWY
1410 1420 1430 1440 1450
GSTDPFRGLN CFAGDALVTY LSRDDVQTAI HSRKQPLWVD CADENPANHF
1460 1470 1480 1490 1500
RYHTQEKYYD MQNTISDIMD SKWYTQNSMR LMFYNGDVDT ICQFLGDQWL
1510 1520 1530 1540 1550
IEKLVTRRNL TVTSPRQPWY YQQGSQYVTT IAGYAKSWTQ NLVQLTVKGS
1560 1570 1580 1590 1600
GHFVPSDRPA QALQMLTNFL SNQANYSTPA GIDVTPQPLT NVISQTNCTT
1610 1620 1630 1640 1650
GQTDRIINLP GLPADMLFKQ YSGFLDGLSG HKVHYWLVES ENNPSTDPLL
1660 1670 1680 1690 1700
LWLNGGPGSS SLMGLFEENG PFRVSKDSQT LSRNPYSWNK FANVLYLESP
1710 1720 1730 1740 1750
IGVGYSYAYN NTNIQYDDVT TAQENYAALK SFFAQYPQYT TSDFYTTGES
1760 1770 1780 1790 1800
YAGVYLPGLS ALLVQGIKSG DININYKGVS IGNGVIDKRT DMNSQLHYQY
1810 1820 1830 1840 1850
YHGGISATTY NTALQLCCSG DEFKCRFSDR MTNFNNSIPW GDLSDPCYDF
1860 1870 1880 1890 1900
VVATGAQLLL TAFDPYNMYQ QCWTIPYNDT TPRTPYGETW TGINYESSDF
1910 1920 1930 1940 1950
LNGYPCYDDS AMEGYLNRPV VRKALNIPDS VPYWAANNNI INAYNQQVDS
1960 1970 1980 1990 2000
IVPNLQIIMA NAPANFKMLL YSGDADTMVN WLGAEIFTAN NFAALGLTTS
2010 2020 2030 2040 2050
SPRAQWTFQY NSTFQPTVAG YQTSYTSNAI NIDVLTVKGS GHFVPLDRPQ
2060 2070 2080 2090 2100
QALQMIYNFV KSRGYNTPFD LNSNFTTTTT TSTTTTTPGT GPTVTAAQTT
2110 2120 2130 2140 2150
TTTPSTPGAG TTGTPGTGPT VTAAPTNGIS TTQPIITTTK GAEGRGVLTI
2160
MATILSVLLF N
Length:2,161
Mass (Da):240,430
Last modified:February 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FE2524C9EED28A8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCO25893.1

NCBI Reference Sequences

More...
RefSeqi
NP_510452.4, NM_078051.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y16B4A.2; Y16B4A.2; WBGene00012445

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
181572

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y16B4A.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCO25893.1
RefSeqiNP_510452.4, NM_078051.6

3D structure databases

SMRiK8ESM2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y16B4A.2

Protein family/group databases

MEROPSiS10.A57

Proteomic databases

EPDiK8ESM2
PaxDbiK8ESM2
PeptideAtlasiK8ESM2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY16B4A.2; Y16B4A.2; WBGene00012445
GeneIDi181572
KEGGicel:CELE_Y16B4A.2

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181572
WormBaseiY16B4A.2 ; CE48023 ; WBGene00012445

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
InParanoidiK8ESM2
KOiK13289
OMAiDPYNMYQ
OrthoDBi607679at2759

Enzyme and pathway databases

ReactomeiR-CEL-2132295 MHC class II antigen presentation
R-CEL-6798695 Neutrophil degranulation

Gene expression databases

BgeeiWBGene00012445 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di3.40.50.1820, 4 hits
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 12 hits
PfamiView protein in Pfam
PF00450 Peptidase_S10, 4 hits
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 4 hits
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 4 hits
PS00131 CARBOXYPEPT_SER_SER, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK8ESM2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K8ESM2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2013
Last sequence update: February 6, 2013
Last modified: May 8, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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