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Protein

RNA polymerase II transcription factor B subunit 2

Gene

Bathy11g03500

Organism
Bathycoccus prasinos
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:Bathy11g03500Imported
OrganismiBathycoccus prasinosImported
Taxonomic identifieri41875 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaprasinophytesMamiellophyceaeMamiellalesBathycoccaceaeBathycoccus
Proteomesi
  • UP000198341 Componenti: Chromosome_11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili132 – 155Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

K8EKQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGCSFSQSS SKYSSGSSQS AFVEFFAHLS EEKINHLYTI SPWATLAVLR
60 70 80 90 100
ALTPLAKQYI MRCVFLPEGA KQRTRWRLKA LVQLRAFVEV ESHSSEEEGK
110 120 130 140 150
KEENASKGGG FIVHEHFRKH VKRAIERGFE DLDDEEEEEK ENEGEKKKKK
160 170 180 190 200
KANVKTTNTT STTTTRFNEE DAGFLDHYAK SRWETVLLEL TSEASVEKKR
210 220 230 240 250
KKKKMMKKKG DGGAGAQHAL HLRKLFYAAR LITKDGRITS EGFSFLLGAT
260 270 280 290 300
SEQIWILLAR YARGGDFEKK MKNKTTNEEN GEGDKMETNG EDEKQQHKLK
310 320 330 340 350
SDESSAAAMA FLVRLSFQHP GRKYSKANLS EAERRVASHL SALGVLYENE
360 370 380 390 400
DDENDNNWYV PTVLSAGLSS VSTTSSAKSA LARIDGHIIV ETNFRVYAYT
410 420 430 440 450
HSELETEVLR LFTRPDYKLP NAYVGMITRD SILDAMRAGI SPDQIVNYLQ
460 470 480 490 500
TRAHPRCTIG KRPNHPAVPP TVCDQIRLWA RDLYRVKADD CVMYTDFPMQ
510 520 530 540
GNQFQDAVNN ARNVGAQILW MDENKRRFAV DADSHERLKV FL
Length:542
Mass (Da):61,516
Last modified:February 6, 2013 - v1
Checksum:i9EC9F58297BE1135
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082268 Genomic DNA Translation: CCO18621.1
RefSeqiXP_007510276.1, XM_007510214.1

Genome annotation databases

GeneIDi19013029
KEGGibpg:Bathy11g03500

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO082268 Genomic DNA Translation: CCO18621.1
RefSeqiXP_007510276.1, XM_007510214.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19013029
KEGGibpg:Bathy11g03500

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK8EKQ5_9CHLO
AccessioniPrimary (citable) accession number: K8EKQ5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 6, 2013
Last sequence update: February 6, 2013
Last modified: February 28, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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