Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 30 (08 May 2019)
Sequence version 1 (06 Feb 2013)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Nonribosomal peptide synthase sidN

Gene

sidN

Organism
Epichloe festucae (strain E2368)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthase required for the biosynthetis of epichloenin A, an extracellular siderophore that plays a crucial role in endophyte-grass symbioses (PubMed:23658520). SidN assembles epichloenin A by activating and incorporating three trans-anhydromevalonylhydroxyornithine (trans-AMHO), 1 glutamine and 4 glycine moieties (PubMed:23658520). Trans-AMHO is produced from L-ornithine via 2 steps involving a L-ornithine N5-monooxygenase and an AHMO-N5-transacylase that have still to be identified (PubMed:23658520). The third adenylation domain (A3) of sidN incorporates the hydroxamate groups of the siderophore which forms an octahedral iron complex (PubMed:23658520). The other component amino acids are assembled by sidN adenylation domains A1 and A2 (PubMed:23658520).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthase sidN1 Publication (EC:6.3.2.-1 Publication)
Short name:
NPRS sidN1 Publication
Alternative name(s):
Epichloenin A synthetase1 Publication
Extracellular siderophore synthetase N1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sidN1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEpichloe festucae (strain E2368)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri696363 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaeEpichloe

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to the accumulation of the intermediate N-5-trans-anhydromevalonyl-N-5-hydroxyornithine (trans-AMHO), displays sensitivity to oxidative stress and shows deficiencies in both polarized hyphal growth and sporulation (PubMed:23658520). Changes its interaction with the plant Lolium perenne from mutually beneficial to antagonistic (PubMed:23658520).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004443811 – 4690Nonribosomal peptide synthase sidNAdd BLAST4690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei816O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1926O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3040O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3598O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4156O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is repressed by iron (PubMed:23658520).1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini779 – 856Carrier 1PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini1889 – 1965Carrier 2PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini3002 – 3079Carrier 3PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini3564 – 3637Carrier 4PROSITE-ProRule annotation1 PublicationAdd BLAST74
Domaini4119 – 4195Carrier 5PROSITE-ProRule annotation1 PublicationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni238 – 656Adenylation 1Sequence analysis1 PublicationAdd BLAST419
Regioni925 – 1175Condensation 1Sequence analysis1 PublicationAdd BLAST251
Regioni1349 – 1760Adenylation 2Sequence analysis1 PublicationAdd BLAST412
Regioni2001 – 2285Condensation 2Sequence analysis1 PublicationAdd BLAST285
Regioni2464 – 2869Adenylation 3Sequence analysis1 PublicationAdd BLAST406
Regioni3121 – 3530Condensation 3Sequence analysis1 PublicationAdd BLAST410
Regioni3679 – 4087Condensation 4Sequence analysis1 PublicationAdd BLAST409
Regioni4262 – 4589Condensation 5Sequence analysis1 PublicationAdd BLAST328

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity). SdiN has the following architecture: A-T-C-A-T-C-A-T-C-T-C-T-C (PubMed:23658520).By similarity1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 3 hits
3.30.559.10, 5 hits
3.40.50.12780, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 3 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 5 hits
PS00012 PHOSPHOPANTETHEINE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K7NCX6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQVAVTRFP ALHCFEGPKQ RQSVGSNARH HTIRGNIDTQ HQSQDETLRR
60 70 80 90 100
FANFVSSLVG DDEISFDFII SPSNGGSDIA ESGTAQAKKD PTQATSDYNG
110 120 130 140 150
ITLLRSTPFV ESGHSEFGII IRRQLRNNDS SLFTLEKSFV VAVDKSSYSV
160 170 180 190 200
RICRDLVPRP LLQSISTSLC SYMGWTNPSQ HSEEESNQEL QLQTLNFQGQ
210 220 230 240 250
SVLNHPPLMT PPDFESQLCL PKRPQEYAKP LLHNAFLARV RENPGRIALD
260 270 280 290 300
ALSSTGRATY TYKSLDDLSS DLAEKILQII GVDADHTDRN ITVALSTSAE
310 320 330 340 350
LYIAWLGILK AGCVVSPVPT DCPSGLLQHM TGLTSSKVVL GSAETLEYFD
360 370 380 390 400
RIIGDSSTFT FINVETIARQ NYEHLLQRPP PLVNTSENDV AYILFTSGST
410 420 430 440 450
GKPKGVQITH HAAVCSIAAN IAASPYSFES GPSSIRWFQM AAPTFDLSVL
460 470 480 490 500
EIFVTFSIGG TICACDRTMM LTDAESVITQ LEATITMTTP TLASLLRPSR
510 520 530 540 550
IPKLREVWVC GEMLKREASE LFARDRDPSV ADGDTNLLNA YGPTEATITC
560 570 580 590 600
TVDARVSLKH RGSLIGPPLP TCSNIILDSS EPPKAVPLGF AGELAIGGPQ
610 620 630 640 650
LSIGYLKSPE KTAAAFVDVE PYGKLYRTGD MARLIMGPDG TLQVEFLGRL
660 670 680 690 700
SSDQIKILGR RVELGEIEAG LRNPLIAEVA AVALKPEVSG LPQVQLIAVV
710 720 730 740 750
TCRTEKSDSD ILAACQERAE NVLQPHMRPS IYYVMDKLPR LASEKTDRKT
760 770 780 790 800
LAKYCLSPEK SGLRRLRNGD VDGHREAGSS SIPMLQSVIE AVSSVAIVGS
810 820 830 840 850
DKITSATTLL SLGIDSLRSV RLLQNFREIG IEGLQVTDIL TCHNLGDLDT
860 870 880 890 900
KAQQALNRST PSLAKARNLQ TLLIDFENRH KKQCLSALGF NEDNIVSFLP
910 920 930 940 950
VTTSQAVALA SFLLTADANG FQAVPGGKAF IQHTVYTVKP ELNSQRIVES
960 970 980 990 1000
WTRVLSRYDI MRSVFVEVND DLTPFAQCIL SPDHEAAQIK PHFYSAKSDN
1010 1020 1030 1040 1050
ECKDVIQAAQ KAAEEKISLY EPPRRLSVVQ SPTQTIIVFS QLHSVFDGGS
1060 1070 1080 1090 1100
ETLLLEDIER EYFGQPSIER TGVLTAVERH FSENRAEAAQ FWQAYMDGFL
1110 1120 1130 1140 1150
SPSFPCLRST VPGPDENVCG GYSFMSDLSL ESLTRQAAAL QCSPLSILQA
1160 1170 1180 1190 1200
AWAQILFTYT GERDVAFGNT MSGRFTTELV NCSAPVLTIQ STRVNLNEEN
1210 1220 1230 1240 1250
DKRNIDILLE RTAQNTAALS YLHTPITGAR YDTTIALQMY LNSGKGEALY
1260 1270 1280 1290 1300
ERVCHPGMQN DLAVMIEVYP DRSGLLEFRL TYQTALLDDD AAYTMLANLA
1310 1320 1330 1340 1350
RVTNHIMSYP NAKYMDPSVW TSLQGPGQLE QINGYHHLGQ QLLHECVAEF
1360 1370 1380 1390 1400
AQKSPNAIAL AFYDDLSVDH PKVQLTYADL EVKATRVAGF LMSQLPAKEG
1410 1420 1430 1440 1450
SKHVVPIFME KCPELYITLL GILKAGAAWC PVDPSYPPAR QIFLIEKTTA
1460 1470 1480 1490 1500
GICFTSKSTT SQLSSILPAS FKSISVSDLL EGGSCSTSRT LKASESARLD
1510 1520 1530 1540 1550
NLSIQRSDIA YVIFTSGTTG TPKGVPISHE SASLSIDSYI QRVNVDLDLR
1560 1570 1580 1590 1600
GCEVRFLQFA NYTFDAFVCD VFTAWRLGGT LVSATRDILL GSFIALANKV
1610 1620 1630 1640 1650
GATHTSMTPT FASTLQPQDF ETLRVATMGG EVLPQILADK WKSRMSLCNV
1660 1670 1680 1690 1700
YGPAETAINT TINRLSAASR SGNIGTALPA VNAYVMASGY PVMKHMLGEL
1710 1720 1730 1740 1750
VISGPQLSPG YWDNVHSSNN RFRWNSTLQC RVYHTGDYVR QLADGSFDFV
1760 1770 1780 1790 1800
GRKDDLVKIR GMRVELTEIS TVCSAGHESV VHSEVLLAKL PGSTQSSLIC
1810 1820 1830 1840 1850
FVDCGLQKSS DVDNFCILKN EEAQLVAQAV KRHATAELPR HMVPDVFMPL
1860 1870 1880 1890 1900
NCLPRNQSSK VNRKRLLEVI GREWSMQPMS PVADEQVDPA WCIKHRPLLE
1910 1920 1930 1940 1950
KIQGVIKIMP TTLSRSTTLS ELGVDSIGAI RLSSRLKNDG HDISAIQVLD
1960 1970 1980 1990 2000
SVTIEDLINH LSVKRQGTSN WKTLLSRYLD HWKPLVSRHL ARDPAHFSLV
2010 2020 2030 2040 2050
PTTVFQDGML VETLRDPMLY WASYSWRLPS TVDIARVRQA WQHVSKNHDI
2060 2070 2080 2090 2100
LKVSFVPTAY FEQEETQSSG PSSMFIQLID YNASMGWQEI VSDSGDWQQS
2110 2120 2130 2140 2150
IHALCANLQR TQHENNFSSP PWRVTILAQQ DQRIMNLTIH HSLCDGEMLR
2160 2170 2180 2190 2200
SLMHDVAWAY STAELPVKRC QVQEAVSRLA VRYSEPEGHK FWGDMLSPLV
2210 2220 2230 2240 2250
SQTSLGDATS NSPKAVVRKI RHRTTELQAT RSTSKLTGLA RRLGASSLSP
2260 2270 2280 2290 2300
LFRVTFGIML TEYYEQQSVL FGEVRSERLL ESQLVGAMAP LSATYPVPFR
2310 2320 2330 2340 2350
SSGNLKDMVH SQQILVMDSI RYGPPQPSDV RKILKKSRDE ALYSAVYVLR
2360 2370 2380 2390 2400
QRSEDDGGSL APWEEFKDIF EIFVDHEFAL NVLEGADDTV TISLSVDETL
2410 2420 2430 2440 2450
MSSSAQAIFL QQLDALLIAF DKSAPEISLS GLNAHFPLDL LSIASSKVSA
2460 2470 2480 2490 2500
QYTSTVPPSH YIETWAKTHP EWKAVEVATG FLGSQKIVTE DWTYKKLNET
2510 2520 2530 2540 2550
ANQVANLIIH ASLHGRAIAV SLDRSLIAFA IIVGIMKSGN TYVPIEAGLP
2560 2570 2580 2590 2600
NDRKSFLLRD SRAAMAFVCD NNFDGVELPP ETKVLDTKNQ SFIENLSTQD
2610 2620 2630 2640 2650
TSDILNNYPE NLDAYLLYTS GSTGAPKGVR VSRHNLSSFS DAWGKLIGNV
2660 2670 2680 2690 2700
APKSLELGGV GKFLCLASRA FDVHIGEMFL AWRFGLCAVT GERLSMLDDL
2710 2720 2730 2740 2750
PRTFRELGVT HAGIVPSLLD QTGLVPEDAP HLVYLGVGGE KMTPRTQQIW
2760 2770 2780 2790 2800
SSSDRVALVN VYGPTEVTIG CSAGRILPDS DTRCIGHPLG DSVAHVLAPG
2810 2820 2830 2840 2850
SNEHVKKGMA GELVIEGSLV ANGYLNRPDA KGFCDINGRK MYRTGDIVRM
2860 2870 2880 2890 2900
DADSSILFLG RKDEQVKVRG QRLELGEVSE VIRSLSPTDI DVVTLLLNHP
2910 2920 2930 2940 2950
GTSKQFLVSF VASSGAAVRG ELRWINENYK EINNSLRQAC EQTLPAYMVP
2960 2970 2980 2990 3000
DFIIPISFIP LRDTSAKTDA KALEHMFHTL SLGELFGESS SLVNKPTTAP
3010 3020 3030 3040 3050
SRDLTSIEKQ ILTVVKSVVG QDDKRDARPG STLFQLGLDS IASVKLSFKL
3060 3070 3080 3090 3100
KKLGFSTTVA RLLQNPTIEE LGRMKNALKG SHHAEPSNSE SITTRFEELE
3110 3120 3130 3140 3150
KETMNSLKDR ETTHIESIRP CMPLQEVLVA HTMSHGSEAD NAYVSHMIFE
3160 3170 3180 3190 3200
LDPAVVVEHV KAAWAAVVKN TELLRTCFID RENDIVQLVI KENHATPVWK
3210 3220 3230 3240 3250
HLSNGTNMLK EELLSCKKEI ADDIVTNIDK SPPVRFTLAS CDGADETNEM
3260 3270 3280 3290 3300
SLFMLSIHHA LYDMVSIEMI FQDFEVAYTD SSLSRRPSTL PLLEHIAAQQ
3310 3320 3330 3340 3350
QNESKAKSYW TTLFDGYDHR IEKISPRTAQ TTARTLNASL TTLESLCSQT
3360 3370 3380 3390 3400
NMTLSALIQG VFAYVLARTL KRPDLIFGVV LSGRSIDVEG IDAMAAPCIS
3410 3420 3430 3440 3450
TIPQRLNIGT DGETIAELIT TVQDRLFKSM EYQYTSLRSL SRWLEISGPL
3460 3470 3480 3490 3500
FSSLFSFTKL SPPEDSGSSK SRILKPTEGE MFLDFELALE CEADPGTDTV
3510 3520 3530 3540 3550
TLRTRSTMFD KMEELDALLE QMESLVTSFT RGENKAVDGD FGSMLHTRLL
3560 3570 3580 3590 3600
PPHGSLQEES DDWSVLEQQI RDVVVAFSGA SPNEVKRTTP FIKYGIDSIT
3610 3620 3630 3640 3650
TIRFSTLLRK NGFWVSGADV LRNPSVAKLA THIQTTSSFN GTAKDSDDEA
3660 3670 3680 3690 3700
SESAGIGNWS KALLAGAVST KVLDDVVAVY PLTPLQAGMI SATVMMDPTL
3710 3720 3730 3740 3750
YAHHHPFRLP QGTSIDQVRS AWSRLVAKHD ILRTSFHEIN QPRPQLVGAV
3760 3770 3780 3790 3800
HQESILNWHE VATEDVQVAI DDLIKRTQFP SVSSFETPPV KATVIRSPED
3810 3820 3830 3840 3850
MLLVVSLHHA TYDGTSIRFI FEDLWAILRG NRVPERNPFY ETAMKIHNMS
3860 3870 3880 3890 3900
SGSVGFWADS LSGYGGAAAI AEAEDIQNKM TSKTMLLAQD TSALEQWCTE
3910 3920 3930 3940 3950
KGITIQTICQ LAVSKAVCAQ TKSRDVVLGQ VHAARLDING ADKVAGPMLN
3960 3970 3980 3990 4000
TVPLRLCIHD DSFTNHDYLR DLQAFQNKSL DHLHASLSDI QRLWRKENGR
4010 4020 4030 4040 4050
DGQLFEVLFI FRKGEDATEA PFWQPFEPEG SKESLPPSHY DLVIEVHQKS
4060 4070 4080 4090 4100
RGGLELEVHS RFADDTTSNL MSLLVESFES IRKHPDELAI SSPGVLSKVP
4110 4120 4130 4140 4150
KPGLTRETGA VPTSPFDQSA IDQFLDPLRK VLSETTDTPV SSIDAQTSIF
4160 4170 4180 4190 4200
SIGVDSIVAI RVAGACRKAH IPLHTMEIMR NAKIGKLCEV AFAKSGQAAP
4210 4220 4230 4240 4250
NRSTTESNGV APLLDQEVKK AAASKLGRAE AEIQEILPVL PGQEYHLACW
4260 4270 4280 4290 4300
LTSGKTLLEP VWVFKAENGL DAGRLRDTWI SLVQKNDSLR TCFAQVKPTL
4310 4320 4330 4340 4350
AVQAILKPDC VDAAKSFTVQ QVPENMTMEE YVKSEIHHLS LSPSSLYEPP
4360 4370 4380 4390 4400
VRIVLIQGGR EGVSVLLRLH HALYDAWSMG ILIDELSSLY CGTMQKPCPP
4410 4420 4430 4440 4450
LSVSHFAQFT QQKLRGKNEE QFWTETLGQC DPTILTPKAD INTDSKSCNR
4460 4470 4480 4490 4500
AFVSFECVDV SMGALKSAAR AFGITPQCLI QVAFGRMLSD VTESSSPVFG
4510 4520 4530 4540 4550
YYTAGRSAEL EGIEALASPT LNMLPVAVPK DLVASQLAGT SLSILLQSFQ
4560 4570 4580 4590 4600
DRTNSQSDYE QSRLRDVIKW APNKGVSPLF NAHLNILWND EILLKPQVSK
4610 4620 4630 4640 4650
DTLLRPWPLG VPSDYASPTP LSRGSSVDGL DTSFLPTNVL FADVGPSRET
4660 4670 4680 4690
ANLAIGIGCD PTLRDAQGLE EIARMFSGHL SRLVGSRDLV
Length:4,690
Mass (Da):516,329
Last modified:February 6, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB696F23D447239C9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JN132403 Genomic DNA Translation: AET13875.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JN132403 Genomic DNA Translation: AET13875.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.30.559.10, 5 hits
3.40.50.12780, 3 hits
InterProiView protein in InterPro
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 3 hits
PF00668 Condensation, 5 hits
PF00550 PP-binding, 4 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 4 hits
SUPFAMiSSF47336 SSF47336, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 3 hits
PS50075 CARRIER, 5 hits
PS00012 PHOSPHOPANTETHEINE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIDN_EPIFE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7NCX6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: February 6, 2013
Last modified: May 8, 2019
This is version 30 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again