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Entry version 61 (07 Oct 2020)
Sequence version 1 (09 Jan 2013)
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Protein
Submitted name:

Vomeronasal 2, receptor 10

Gene

Vmn2r10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Vomeronasal 2, receptor 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vmn2r10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1316730, Vmn2r10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei581 – 606HelicalSequence analysisAdd BLAST26
Transmembranei618 – 639HelicalSequence analysisAdd BLAST22
Transmembranei651 – 675HelicalSequence analysisAdd BLAST25
Transmembranei695 – 719HelicalSequence analysisAdd BLAST25
Transmembranei739 – 763HelicalSequence analysisAdd BLAST25
Transmembranei775 – 795HelicalSequence analysisAdd BLAST21
Transmembranei801 – 823HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500390880122 – 847Sequence analysisAdd BLAST826

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
K7N621

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
K7N621

PRoteomics IDEntifications database

More...
PRIDEi
K7N621

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000067010, Expressed in pancreas and 7 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000078162

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
K7N621, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini581 – 845G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST265

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1056, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183069

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005389_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K7N621

KEGG Orthology (KO)

More...
KOi
K04613

Database of Orthologous Groups

More...
OrthoDBi
546292at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
K7N621

TreeFam database of animal gene trees

More...
TreeFami
TF340115

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR004073, GPCR_3_vmron_rcpt_2
IPR028082, Peripla_BP_I

The PANTHER Classification System

More...
PANTHERi
PTHR24061, PTHR24061, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00248, GPCRMGR
PR01535, VOMERONASL2R

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

K7N621-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNLCVFTLS FFLLEFSLIL CHLTEPICFW RINNNEDNDG DLRSDCGFFL
60 70 80 90 100
AAVEGPTDDS YNISDLRIPA RRYEFFLVMF FATDEINKNP YLLPNMSLIF
110 120 130 140 150
PINHGQCEKT LGDLDKIYSE KNYTVEFTDY ICVSFGTCFI ALIGPSWKTS
160 170 180 190 200
IKLSINSGTP RVFFGPFNPK LSDHDQFPYV HQVATKDTRL SHAMVSLMFH
210 220 230 240 250
FTWIWIGMVI SDDDQSIQFL SDMREEMQRH GICLAFVNMI PEDMQLYMTR
260 270 280 290 300
ATIYDKQIME STAKVVMIYG EMNSTLEVSF RRWEDLSIRR IWITTSQWDV
310 320 330 340 350
ITNKNDFSLD FFQGTVTFAH HVGEIANFRN FLQTMNSEKY TVNISESRLG
360 370 380 390 400
WNYFNCSISK NSNKKDHFTF NNTLEWTTLH KYDMVLSEEG YNLYNAVYAV
410 420 430 440 450
AHTYHELVLQ QVESQQMTVP KGTFTDCQQV SSMLKSRIFT NPVGELVNMK
460 470 480 490 500
HRENQCTEYD IFIIWNFPQG LGLKVKIGSY LPCFQQSQQL HISEDLEWAT
510 520 530 540 550
GGSSVPPSLC SVTCTAGFRK IHQKQTADCC FDCDQCPENA VSNETVDMEQ
560 570 580 590 600
CMRCPDDKYA NLEKTHCLQR AVSFLAYEDP LGMALGCTAL SFSALTVLVL
610 620 630 640 650
VTFVKYKDTP IVKANNRILS YILLISLVFC FLCSLLFIGH PNQATCILQQ
660 670 680 690 700
TTFGVFFTVA ISTVLAKTIT VLMAFKLTTP GRRMRGMLAS GAPNIVIPIC
710 720 730 740 750
TLIQLVLCGI WLVTSPPFID RDMQSEHGKT IIICNKGSVI AFHFVLGYLG
760 770 780 790 800
ALALGSFTVA FLARNLPDRF NEAKFLTFSM LVFCSVWITF LPVYHSTQGT
810 820 830 840
VMVVVEVFSI LASSAGLLGC IFLPKCCVLL RIQNSNFLHK YKHELHS
Length:847
Mass (Da):96,454
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i497A1E36D1BBB93B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O35204O35204_MOUSE
Putative pheromone receptor
Vmn2r10 V2r16, VR16
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B2WCF2A0A3B2WCF2_MOUSE
Vomeronasal 2, receptor 10
Vmn2r10
563Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC133456 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_033517.3, NM_009491.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000079163; ENSMUSP00000078162; ENSMUSG00000067010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22307

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22307

UCSC genome browser

More...
UCSCi
uc009vdh.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133456 Genomic DNA No translation available.
RefSeqiNP_033517.3, NM_009491.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078162

Proteomic databases

jPOSTiK7N621
PaxDbiK7N621
PRIDEiK7N621

Genome annotation databases

EnsembliENSMUST00000079163; ENSMUSP00000078162; ENSMUSG00000067010
GeneIDi22307
KEGGimmu:22307
UCSCiuc009vdh.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22307
MGIiMGI:1316730, Vmn2r10

Phylogenomic databases

eggNOGiKOG1056, Eukaryota
GeneTreeiENSGT00950000183069
HOGENOMiCLU_005389_5_0_1
InParanoidiK7N621
KOiK04613
OrthoDBi546292at2759
PhylomeDBiK7N621
TreeFamiTF340115

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22307, 2 hits in 14 CRISPR screens
RNActiK7N621, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000067010, Expressed in pancreas and 7 other tissues

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR004073, GPCR_3_vmron_rcpt_2
IPR028082, Peripla_BP_I
PANTHERiPTHR24061, PTHR24061, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit
PRINTSiPR00248, GPCRMGR
PR01535, VOMERONASL2R
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7N621_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7N621
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: October 7, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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