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Entry version 34 (26 Feb 2020)
Sequence version 1 (09 Jan 2013)
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Protein

Integrase catalytic domain-containing protein

Gene
N/A
Organism
Nasonia vitripennis (Parasitic wasp)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrase catalytic domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNasonia vitripennis (Parasitic wasp)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7425 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaParasitoidaChalcidoideaPteromalidaePteromalinaeNasonia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002358 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini253 – 419Integrase catalyticInterPro annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni345 – 366DisorderedSequence analysisAdd BLAST22
Regioni477 – 561DisorderedSequence analysisAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili177 – 197Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi517 – 540PolyampholyteSequence analysisAdd BLAST24
Compositional biasi541 – 559PolarSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KGFB Eukaryota
ENOG410XS4D LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001650_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K7JC54

Identification of Orthologs from Complete Genome Data

More...
OMAi
GMGVKFD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
K7JC54

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025724 GAG-pre-integrase_dom
IPR001584 Integrase_cat-core
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR013103 RVT_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13976 gag_pre-integrs, 1 hit
PF00665 rve, 1 hit
PF07727 RVT_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50994 INTEGRASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K7JC54-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTDFSGNHL NKFDGTNFQA WKFQVRTILV ANDIYDVVTG KKEKPASLTS
60 70 80 90 100
EDGKKWTKEN AKSMYILSSS MLPAQLENYL TCETAKEMWD KMALIFEQKS
110 120 130 140 150
ATNKATLLQK FYTCQMTTSE KVVQYITKVS NMAHALRDLN EPISDEGVIA
160 170 180 190 200
KILGSLPEKY NAFVTAWDSV DPAKQTIVTL QERLIKEEQK LSEQEDKTWH
210 220 230 240 250
ERAGHVNKRT LLHMVKNKLV EGADVEGDPS LACETCHLGK AHRLPFVKKC
260 270 280 290 300
EPHPRKPGEY FHSDICGPMS TESLGGSRYF LLFKDDASGY RHIYCVKHKS
310 320 330 340 350
DTYEKFKEFE RLVFNKFNRS MKVLRTDNGG EFCNQNMQNY MRTKGIKHET
360 370 380 390 400
TAPYTPEQNG RSERDNRTIV ESARTMLLQK DLPKFLWAEA MHTAVYLMNM
410 420 430 440 450
TPTSRNPNKS PYEVWTDKKP SIKHLRVFGS AAVEHIPKLH RTKLDATGRR
460 470 480 490 500
VIIVGYQGDS TNYRVYDPST RKISTSRNVT FLEKENDETE ASEERESDDS
510 520 530 540 550
RDEWQDATNS TEEPVEQQQQ KEPDVSKPTE NDERTPVNNA VEENGEKNPV
560 570 580 590 600
NNTSAGRILR DRSTLKKPSW LRVLSAEIPE PATFQEAITG PDARWWQEAI
610 620 630 640 650
DEELQAHRIN GTWEIVDRPE GCAVIDSKWV FKRQEAKAGK PSKYKARLCA
660 670 680 690 700
RGFSQQYGVD YDETFAPVVR YEAIRTMLAL AVQEDLHIVQ FDVKTAFLHG
710 720 730 740 750
ILKEDVYMAV PEGVYVSDAK NKVCKLVKAL YGLKQSSRCW NDTIKCVLSE
760 770 780 790 800
INLLTSNAER SIFCGMIEND RAYVLLFVDD GLIMARESKT VNYITAVLKE
810 820 830 840 850
KFNVTTCEPD VFVGVKIERD RENGKMFLHQ ADYARKILVR FNMEDANPIS
860 870 880 890 900
TPLEKGLDLS LMKEHCASDI NFPYREIVGS LMYLSVVSRP DITYAVNVLS
910 920 930 940 950
RYLDKYTIVH CKASKRVLRY VKATIDFGIT YVRVKENFDL EGFCDSDFAG
960 970 980 990 1000
ETQTRRSTSG YIFKICKGPI SWCAQRQSMV ASSSTEVEYL AANLACKEAM
1010 1020 1030 1040 1050
WLRQLMADIG YPCANPTVLQ IDNQSAMQLI KNPVYGDINV KYVSTLVQLA
1060 1070
DILTKALPRS RHEELCGLIG LHHM
Length:1,074
Mass (Da):122,554
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8C12C91CDF5AB39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAZX01015857 Genomic DNA No translation available.
AAZX01019482 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
NV18998-RA; NV18998-PA; NV18998

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZX01015857 Genomic DNA No translation available.
AAZX01019482 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiNV18998-RA; NV18998-PA; NV18998

Phylogenomic databases

eggNOGiENOG410KGFB Eukaryota
ENOG410XS4D LUCA
HOGENOMiCLU_001650_5_1_1
InParanoidiK7JC54
OMAiGMGVKFD
PhylomeDBiK7JC54

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR025724 GAG-pre-integrase_dom
IPR001584 Integrase_cat-core
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR013103 RVT_2
PfamiView protein in Pfam
PF13976 gag_pre-integrs, 1 hit
PF00665 rve, 1 hit
PF07727 RVT_2, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7JC54_NASVI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7JC54
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: February 26, 2020
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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