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Entry version 38 (16 Jan 2019)
Sequence version 1 (09 Jan 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

100121676

Organism
Nasonia vitripennis (Parasitic wasp)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:100121676Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNasonia vitripennis (Parasitic wasp)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7425 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaParasitoidaChalcidoideaPteromalidaePteromalinaeNasonia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002358 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7425.NV18057-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 156Helicase ATP-bindingInterPro annotationAdd BLAST134
Domaini432 – 590Helicase C-terminalInterPro annotationAdd BLAST159
Domaini613 – 708Dicer dsRNA-binding foldInterPro annotationAdd BLAST96
Domaini886 – 1032PAZInterPro annotationAdd BLAST147
Domaini1378 – 1573RNase IIIInterPro annotationAdd BLAST196
Domaini1657 – 1817RNase IIIInterPro annotationAdd BLAST161

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG0571 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
K7J9I6

KEGG Orthology (KO)

More...
KOi
K11592

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKPDQPC

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
K7J9I6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K7J9I6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFFFNDHIH TKSFTPREHQ VELLYSAKEK NIIICLGKIT EQTFIVTKVI
60 70 80 90 100
QELAINNRRT LSHDGKRTIY LLENEEACTE KANHIKQLTD LKVLKCNDVK
110 120 130 140 150
DFDSKEFSSN TQVLILTVDM CSKLLLANKI NPNQINLLII DKCHNLVTNC
160 170 180 190 200
KLSKILNIFR NCDSTTKIIG FAVPLYSLTK EPGALSYEIE RIESLLQCQI
210 220 230 240 250
ETASDLLSIL RYSPKPKEYL LAYKIEDKKV VEKDITDFTS FTLNFLSDHR
260 270 280 290 300
YDPTEIYSEE FLEDIKKIPN PVHKPCQMIE EFLRILNTLG LWAADKAALV
310 320 330 340 350
LLMLIEKLKI KTPYERHYLL FSVVATLFLK IRAYCDDIFS GLTEAEKILK
360 370 380 390 400
FSTPKIHRLI EVLKTFSPPP KEETVTPNNR VEKNDSANTK DQNHDKSVKN
410 420 430 440 450
LHKKTDGGFK KFRPFRHSRG LTDPDLLCGV IFVDDAVTAK VLFYLLNEMS
460 470 480 490 500
KCEESLHFLS PLFTSEKSND ELFCGRDLEL EYRKQEEVLK KFRIHECNLL
510 520 530 540 550
ISTAILEEGI DIPKCNFVMR FEFPKNYQSY VQCKSRARAT DALHVLLVPE
560 570 580 590 600
IESEVYIQRL AHYHYIEKIL LSKCTSKEAD ECEETEADAY DSVLPEYKPL
610 620 630 640 650
DEEDAPKVTL NSAISLVNRY CAKLPSDTFT KLTPEWKINN ITVENKQMYI
660 670 680 690 700
CSLRLPINSP LKYSISSYPM PNKALAKRMA ALQMCVCLHK ENEIDDYLLP
710 720 730 740 750
VGKENFKAHP EDSEVPALPD DENMDLTEAR PGTTKRRQYY YKKIADALID
760 770 780 790 800
CKPELEEPCY LYHINMVLSC PLPEEQNTRG RKIYPPEESD IGFGILTRKK
810 820 830 840 850
IPKVCPFPIY TRSGEVRVDL KLSKETVVLD ESKIDKVVSF LNYTFTNVLR
860 870 880 890 900
LQKYLMLFDP NVSENSYIIV PVKKQPNASD ICVDWDFVEC IYANRDSMPN
910 920 930 940 950
RISEENRQNF VFEASKYHDA VIMPWYRNQD QPQYFYVAEI CNHLNPKSSF
960 970 980 990 1000
PGADYSTFEE YYSKKYGIQI QNLEQPLLDV DHTSARLNFL TPRYVNRKGV
1010 1020 1030 1040 1050
ALPTSSEETK RAKRENLEQK QILIAELCAI HPFPASLWRQ AVCLPCILYR
1060 1070 1080 1090 1100
INALLLADQI RRHVAQSISL GQETLDEDFN WPPLDFGWSL ADVLKKSKEN
1110 1120 1130 1140 1150
EKTNSNKPEK EKSDKIKEEA PAVKEKPENI KAERLDDSGN DEMEIGTWSN
1160 1170 1180 1190 1200
EMVNMAPVVV ADAGLAVQSN YEWGNIRYGS PTYDSEFDDA SINSSDDDFG
1210 1220 1230 1240 1250
DDSDSDSQYD KEEGLTIAYT GDNVAEAFDK KGKAFEAEKE KQNCVELQEK
1260 1270 1280 1290 1300
SELMHWNFEG DLSDEFYQLH RLAHIDKAKM NVEIILSQDI FIPCDKPVAF
1310 1320 1330 1340 1350
KRKTSKVLNN SYVERKHEEY VSVVSNYFKH ELIESAKKRR NKQGPAELTK
1360 1370 1380 1390 1400
LVPKYNKGSF SFDYQPELDG HSGPSPSLIL QALTMSNAND GINLERLETI
1410 1420 1430 1440 1450
GDSFLKYAIT TYLFCTYNNI HEGKLSHLRS KQVSNLNLYR LGRQKMLGES
1460 1470 1480 1490 1500
MIASKFEPHD NWLPPCYYVP KELEQALIES GVPSAMWNQA DIPPFSRFSE
1510 1520 1530 1540 1550
INDLVRETEH KLEIIKSELS QSEHGALNGL NGLTGDPLRS FIPYNLITQH
1560 1570 1580 1590 1600
SIPDKSIADC VEALIGAYLI ACGPRGALLF MSWLGIHVLP TEEVVTISDS
1610 1620 1630 1640 1650
KPTDRLPGST PYVELGEEGG STKWTQLRYK KLQEPPSPLF YNVPQPEIEL
1660 1670 1680 1690 1700
EIMLDGYDSL ERSIGYTFRN RSYLLQAFTH ASYQPNRLTD CYQRLEFLGD
1710 1720 1730 1740 1750
AVLDYLITRH LYEDPRQHSP GALTDLRSAL VNNTIFASLA VRCGFHKYFR
1760 1770 1780 1790 1800
HLSPGLNTVI DRFVRIQEEN GHSISEEYYL IGEREFEEAE EAEDVEVPKA
1810 1820 1830 1840 1850
LGDVFESLAG AIYLDSNMSL DAVWAVYFEI MKSEIEQFSA NVPKSPIREL
1860 1870 1880 1890 1900
LELEPETAKF GKPEKLADGR RVRVTVDVFG KGSFKGIGRN YRIAKCTAAK
1910
CALKKLKKSQ SCIKGRK
Length:1,917
Mass (Da):219,668
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB021EDAC55F56690
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_001605287.1, XM_001605237.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
NV18057-RA; NV18057-PA; NV18057

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100121676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nvi:100121676

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_001605287.1, XM_001605237.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7425.NV18057-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiNV18057-RA; NV18057-PA; NV18057
GeneIDi100121676
KEGGinvi:100121676

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
InParanoidiK7J9I6
KOiK11592
OMAiPKPDQPC
OrthoDBi1337630at2759
PhylomeDBiK7J9I6

Family and domain databases

CDDicd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7J9I6_NASVI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7J9I6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: January 16, 2019
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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