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Protein

Fibroblast growth factor receptor

Gene

FGFR4

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei715Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SSC-109704 PI3K Cascade
R-SSC-1257604 PIP3 activates AKT signaling
R-SSC-1307965 betaKlotho-mediated ligand binding
R-SSC-190322 FGFR4 ligand binding and activation
R-SSC-5654228 Phospholipase C-mediated cascade, FGFR4
R-SSC-5654693 FRS-mediated FGFR1 signaling
R-SSC-5654700 FRS-mediated FGFR2 signaling
R-SSC-5654706 FRS-mediated FGFR3 signaling
R-SSC-5654712 FRS-mediated FGFR4 signaling
R-SSC-5654719 SHC-mediated cascade:FGFR4
R-SSC-5654720 PI-3K cascade:FGFR4
R-SSC-5654733 Negative regulation of FGFR4 signaling
R-SSC-5673001 RAF/MAP kinase cascade
R-SSC-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:FGFR4Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 55HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiK7GRT5

Expressioni

Gene expression databases

BgeeiENSSSCG00000014047 Expressed in 6 organ(s), highest expression level in liver
ExpressionAtlasiK7GRT5 baseline and differential

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 343Ig-likeInterPro annotationAdd BLAST89
Domaini352 – 452Ig-likeInterPro annotationAdd BLAST101
Domaini570 – 858Protein kinaseInterPro annotationAdd BLAST289

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118923

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

K7GRT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGVCTVSEM CSRGVACALY IAIAMHRAVI ACALCVCVCV CVCVCVCVCV
60 70 80 90 100
CFLGSGMCCP ACVLRTVCVI YTRGVALALR VAPVACGCVK VKEHWVSSMS
110 120 130 140 150
KGACAQCVQH VLCMQGADSA RATGLTDLCP GPTEPCLAPS PEEQERELTV
160 170 180 190 200
VLGQSVRLCC GRAERSGHWY KEGSRLAPAG RVRGWRGRLE IASFLPEDAG
210 220 230 240 250
RYFCLARGSM LVLHNVTLVM DDSMISSNGD EDPGTHSGPS NGHIYPQQAP
260 270 280 290 300
YWTHPQRMEK KLHAVPAGNT VKFRCPAAGN PMPTIRWLKD GQDFHGENRI
310 320 330 340 350
GGIRLRHQHW SLVMESVVPS DRGTYTCLVE NSLGSIRYSY LLDVLERSPH
360 370 380 390 400
RPILQAGLPA NTTAVVGSDV ELLCKVYSDA QPHIQWLKHI VINGSSFGAD
410 420 430 440 450
GFPYVQVLKT ADINSSEVEV LYLRNVSAED AGEYTCLAGN SIGLSYQSAW
460 470 480 490 500
LTVLPEEDLT WTAAGPEARY TDVILYASGS LALLVLLLLA GLYRRQVLHG
510 520 530 540 550
RHPRQPATVQ KLSRFPLARQ FSLESGSSAK SSSSLVRGVR LSSSGPPLLA
560 570 580 590 600
GLVSLDLPLD PLWEFPRDRL VLGKPLGEGC FGQVVCAEAF GMDPTRPDQA
610 620 630 640 650
STVAVKMLKD NASDKDLADL VSEMEVMKLI GRHKNIINLL GVCTQEGPLY
660 670 680 690 700
VIVECAAKGN LREFLRARRP PGPDLSPDGP RSSEGPLSFP ALVSCAYQVA
710 720 730 740 750
RGMQYLESQK CIHRDLAARN VLVTEDNVMK IADFGLARGI HHIDYYKKTS
760 770 780 790 800
NGRLPVKWMA PEALFDRVYT HQSDVWSFGI LLWEIFTLGG SPYPGIPVEE
810 820 830 840 850
LFSLLREGHR MDRPPHCPPE LYGLMRECWH AAPSQRPTFK QLVEALDKVL
860 870 880 890 900
LAVSEEYLDL RLTFGPYSPA GGDASSSCSS SDSVFSHEPL PLGPSSFFPG

VQT
Length:903
Mass (Da):98,445
Last modified:November 22, 2017 - v2
Checksum:i5DC73CEBD72241BE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1S3B8F1S3B8_PIG
Fibroblast growth factor receptor
FGFR4
718Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000012 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSSCT00000035375; ENSSSCP00000030615; ENSSSCG00000014047

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000012 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiK7GRT5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000035375; ENSSSCP00000030615; ENSSSCG00000014047

Phylogenomic databases

GeneTreeiENSGT00760000118923

Enzyme and pathway databases

ReactomeiR-SSC-109704 PI3K Cascade
R-SSC-1257604 PIP3 activates AKT signaling
R-SSC-1307965 betaKlotho-mediated ligand binding
R-SSC-190322 FGFR4 ligand binding and activation
R-SSC-5654228 Phospholipase C-mediated cascade, FGFR4
R-SSC-5654693 FRS-mediated FGFR1 signaling
R-SSC-5654700 FRS-mediated FGFR2 signaling
R-SSC-5654706 FRS-mediated FGFR3 signaling
R-SSC-5654712 FRS-mediated FGFR4 signaling
R-SSC-5654719 SHC-mediated cascade:FGFR4
R-SSC-5654720 PI-3K cascade:FGFR4
R-SSC-5654733 Negative regulation of FGFR4 signaling
R-SSC-5673001 RAF/MAP kinase cascade
R-SSC-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Gene expression databases

BgeeiENSSSCG00000014047 Expressed in 6 organ(s), highest expression level in liver
ExpressionAtlasiK7GRT5 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR016248 FGF_rcpt_fam
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PIRSFiPIRSF000628 FGFR, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7GRT5_PIG
AccessioniPrimary (citable) accession number: K7GRT5
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: November 22, 2017
Last modified: September 12, 2018
This is version 43 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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