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UniProtKB - K7GLM4 (K7GLM4_PIG)
Protein
Angiotensin-converting enzyme
Gene
ACE2
Organism
Sus scrofa (Pig)
Status
Functioni
Catalytic activityi
- This reaction proceeds in the forwardARBA annotation direction.
- EC:3.4.17.23ARBA annotationThis reaction proceeds in the forwardARBA annotation direction.
Cofactori
Protein has several cofactor binding sites:GO - Molecular functioni
- carboxypeptidase activity Source: UniProtKB-KW
- endopeptidase activity Source: Ensembl
- identical protein binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: GO_Central
- peptidyl-dipeptidase activity Source: Ensembl
- virus receptor activity Source: Ensembl
GO - Biological processi
- angiotensin-mediated drinking behavior Source: Ensembl
- negative regulation of signaling receptor activity Source: Ensembl
- positive regulation of cardiac muscle contraction Source: Ensembl
- positive regulation of gap junction assembly Source: Ensembl
- positive regulation of L-proline import across plasma membrane Source: Ensembl
- receptor-mediated virion attachment to host cell Source: Ensembl
- regulation of cardiac conduction Source: Ensembl
- regulation of transmembrane transporter activity Source: Ensembl
- tryptophan transport Source: Ensembl
Keywordsi
Molecular function | CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Enzyme and pathway databases
BRENDAi | 3.4.17.23, 6170 |
Reactomei | R-SSC-2022377, Metabolism of Angiotensinogen to Angiotensins |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACE2Imported |
Organismi | Sus scrofa (Pig)Imported |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:85008, ACE2 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Plasma membrane
- Apical cell membrane ARBA annotation
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cilium ARBA annotation
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- apical plasma membrane Source: Ensembl
- brush border membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: Ensembl
- cilium Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 739 – 762 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, CytoplasmARBA annotation, Membrane, SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5015095988 | 18 – 805 | Angiotensin-converting enzymeSequence analysisAdd BLAST | 788 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinUniRule annotationARBA annotation, PhosphoproteinARBA annotationProteomic databases
PeptideAtlasi | K7GLM4 |
Expressioni
Gene expression databases
Bgeei | ENSSSCG00000012138, Expressed in adipose tissue and 31 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
IntActi | K7GLM4, 1 interactor |
STRINGi | 9823.ENSSSCP00000012921 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 617 – 770 | CollectrinInterPro annotationAdd BLAST | 154 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 772 – 805 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 777 – 805 | Polar residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG3690, Eukaryota |
GeneTreei | ENSGT00940000158077 |
OrthoDBi | 422699at2759 |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR031588, Collectrin_dom IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF16959, Collectrin, 1 hit PF01401, Peptidase_M2, 1 hit |
PRINTSi | PR00791, PEPDIPTASEA |
i Sequence
Sequence statusi: Complete.
K7GLM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGSFWLLLS LIPVTAAQST TEELAKTFLE KFNLEAEDLA YQSSLASWNY
60 70 80 90 100
NTNITDENIQ KMNDARAKWS AFYEEQSRIA KTYPLDEIQT LILKRQLQAL
110 120 130 140 150
QQSGTSGLSA DKSKRLNTIL NTMSTIYSSG KVLDPNNPQE CLVLEPGLDE
160 170 180 190 200
IMENSKDYSR RLWAWESWRA EVGKQLRPLY EEYVVLENEM ARANNYEDYG
210 220 230 240 250
DYWRGDYEVT GTGDYDYSRN QLMEDVERTF AEIKPLYEHL HAYVRAKLMD
260 270 280 290 300
AYPSRISPTG CLPAHLLGDM WGRFWTNLYP LTVPFGEKPS IDVTEAMVNQ
310 320 330 340 350
SWDAIRIFEE AEKFFVSIGL PNMTQGFWNN SMLTEPGDGR KVVCHPTAWD
360 370 380 390 400
LGKGDFRIKM CTKVTMDDFL TAHHEMGHIQ YDMAYAIQPY LLRNGANEGF
410 420 430 440 450
HEAVGEIMSL SAATPHYLKA LGLLPPDFYE DSETEINFLL KQALTIVGTL
460 470 480 490 500
PFTYMLEKWR WMVFKGEIPK EQWMQKWWEM KREIVGVVEP LPHDETYCDP
510 520 530 540 550
ACLFHVAEDY SFIRYYTRTI YQFQFHEALC RTAKHEGPLY KCDISNSTEA
560 570 580 590 600
GQKLLQMLSL GKSEPWTLAL ENIVGVKTMD VKPLLSYFEP LLTWLKAQNG
610 620 630 640 650
NSSVGWNTDW TPYADQSIKV RISLKSALGK EAYEWNDNEM YLFRSSIAYA
660 670 680 690 700
MRNYFSSAKN ETIPFGAEDV WVSDLKPRIS FNFFVTSPAN MSDIIPRSDV
710 720 730 740 750
EKAISMSRSR INDAFRLDDN TLEFLGIQPT LGPPDEPPVT VWLIIFGVVM
760 770 780 790 800
GLVVVGIVVL IFTGIRDRRK KKQASSEENP YGSMDLSKGE SNSGFQNGDD
IQTSF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEMK02000112 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSSSCT00000034032; ENSSSCP00000028755; ENSSSCG00000012138 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AEMK02000112 Genomic DNA No translation available. |
3D structure databases
SMRi | K7GLM4 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | K7GLM4, 1 interactor |
STRINGi | 9823.ENSSSCP00000012921 |
Proteomic databases
PeptideAtlasi | K7GLM4 |
Genome annotation databases
Ensembli | ENSSSCT00000034032; ENSSSCP00000028755; ENSSSCG00000012138 |
Organism-specific databases
VGNCi | VGNC:85008, ACE2 |
Phylogenomic databases
eggNOGi | KOG3690, Eukaryota |
GeneTreei | ENSGT00940000158077 |
OrthoDBi | 422699at2759 |
Enzyme and pathway databases
BRENDAi | 3.4.17.23, 6170 |
Reactomei | R-SSC-2022377, Metabolism of Angiotensinogen to Angiotensins |
Gene expression databases
Bgeei | ENSSSCG00000012138, Expressed in adipose tissue and 31 other tissues |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR031588, Collectrin_dom IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF16959, Collectrin, 1 hit PF01401, Peptidase_M2, 1 hit |
PRINTSi | PR00791, PEPDIPTASEA |
MobiDBi | Search... |
Entry informationi
Entry namei | K7GLM4_PIG | |
Accessioni | K7GLM4Primary (citable) accession number: K7GLM4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 9, 2013 |
Last sequence update: | November 22, 2017 | |
Last modified: | January 19, 2022 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |