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Entry version 34 (05 Jun 2019)
Sequence version 1 (09 Jan 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

BRD8

Organism
Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRD8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13735 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraTrionychiaTrionychidaePelodiscus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007267 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13735.ENSPSIP00000020649

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini766 – 836BromoInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni201 – 247DisorderedSequence analysisAdd BLAST47
Regioni583 – 737DisorderedSequence analysisAdd BLAST155
Regioni869 – 891DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili67 – 94Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi644 – 668PolyampholyteSequence analysisAdd BLAST25
Compositional biasi681 – 695PolyampholyteSequence analysisAdd BLAST15
Compositional biasi714 – 737PolarSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

BromodomainPROSITE-ProRule annotationSAAS annotation, Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF07 Eukaryota
ENOG410Y97J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064262

KEGG Orthology (KO)

More...
KOi
K11321

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSGDQNW

Database of Orthologous Groups

More...
OrthoDBi
1509761at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106422

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05507 Bromo_brd8_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038002 BRD8
IPR037966 Brd8_Bromo_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15398:SF6 PTHR15398:SF6, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K7GK38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSGDQNWVS VSRAIKPFAE PGRPPDWFSQ KHCASQYSEL LETTETPKRK
60 70 80 90 100
RGEKGEVVET VEDVIVRKLT AERVEELKKM IKETQEKYRQ LKKDSELIQA
110 120 130 140 150
GHMDSRLEEL CNDIVVKKKM EEEEAEMKRK ATDAAYQARQ AVKNPPRRLT
160 170 180 190 200
GVMVRSPAGS TSPGRDYVLG DLSQQAVEET SPGVMMLPMV TPGTLPSTPV
210 220 230 240 250
ASFIGIPDTP PGSAPLDAPI TPVTDDSPQK KMLGQKATPP PSPLLSELLK
260 270 280 290 300
KGSLLPTSPR LVGESEMAVA SGHMNSSGVL LEVGGVLPVL HGGEMQLASG
310 320 330 340 350
AIPASPAASG APTLSRLLEA GPAQFTTPLA SFSAVASETP AKLLPPPVES
360 370 380 390 400
VSQATIVMMP TLSAPSVVPP SATPESVVTG SQSDTCVSME AVSDPHTVTV
410 420 430 440 450
SMDSSEISMI IDSIKKECLG GGIGSTAGPS KDHTMDGKED LDLAEKMGIA
460 470 480 490 500
VSYTGEELDF ETVGDIIAII EDKGDDHPEV LDVAAVEAAL SFCEETDDPQ
510 520 530 540 550
ALTGXXXXHE QQAQIPQVAV TVKQERQDSE EPEAKEIQDL ISIGDLGSEI
560 570 580 590 600
KTESEELEQN ELDSEEAAVA AVQIAETPEL RSQETEELQK AAAIMGENSK
610 620 630 640 650
AETESAKGGE AAAAAHSTVK IEMLPDDDSS PTHVPSASDD SSQADVQHKF
660 670 680 690 700
ELSESLKEET RAAFGKDAQG EDDDEDGASE AASLEEPKEE DQGEGYLSEM
710 720 730 740 750
DNEPPVSESD DGFSIHNAPL QSHTLADSIP SSPASSQFSV CSEDQEAIQA
760 770 780 790 800
QKIWKKAIML VWRAAANHRY ANVFLQPVTD DIAPGYHSIV QRPMDLSTIK
810 820 830 840 850
KNIENGLIRT TAEFQRDIML MFQNAVMYNS SDHDVYHMAV EMQRDVLEQI
860 870 880 890 900
QQFLATQLIM QTSESGISAK SLRGRDSTRK QDASEKDSVP MGSPAFLLSL
910 920
FDGGTRGRRC AIEADMKMKK
Length:920
Mass (Da):99,032
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35DE111B1D975BDA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AGCU01075741 Genomic DNA No translation available.
AGCU01075742 Genomic DNA No translation available.
AGCU01075743 Genomic DNA No translation available.
AGCU01075744 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_014428307.1, XM_014572821.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPSIT00000020746; ENSPSIP00000020649; ENSPSIG00000018266

Database of genes from NCBI RefSeq genomes

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GeneIDi
102461791

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pss:102461791

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGCU01075741 Genomic DNA No translation available.
AGCU01075742 Genomic DNA No translation available.
AGCU01075743 Genomic DNA No translation available.
AGCU01075744 Genomic DNA No translation available.
RefSeqiXP_014428307.1, XM_014572821.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi13735.ENSPSIP00000020649

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPSIT00000020746; ENSPSIP00000020649; ENSPSIG00000018266
GeneIDi102461791
KEGGipss:102461791

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10902

Phylogenomic databases

eggNOGiENOG410IF07 Eukaryota
ENOG410Y97J LUCA
GeneTreeiENSGT00530000064262
KOiK11321
OMAiCSGDQNW
OrthoDBi1509761at2759
TreeFamiTF106422

Family and domain databases

CDDicd05507 Bromo_brd8_like, 1 hit
Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR038002 BRD8
IPR037966 Brd8_Bromo_dom
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
PANTHERiPTHR15398:SF6 PTHR15398:SF6, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7GK38_PELSI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7GK38
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: June 5, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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