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Entry version 65 (29 Sep 2021)
Sequence version 1 (09 Jan 2013)
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Protein

Tyrosine-protein phosphatase

Gene

PTPN4

Organism
Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei843SubstrateUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei875Phosphocysteine intermediateUniRule annotation1
Binding sitei919SubstrateUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPN4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13735 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinataTestudinesCryptodiraTrionychiaTrionychidaePelodiscus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007267 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13735.ENSPSIP00000010258

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 332FERMInterPro annotationAdd BLAST284
Domaini540 – 612PDZInterPro annotationAdd BLAST73
Domaini678 – 934Tyrosine-protein phosphataseInterPro annotationAdd BLAST257
Domaini851 – 925TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni404 – 425DisorderedSequence analysisAdd BLAST22
Regioni475 – 498DisorderedSequence analysisAdd BLAST24
Regioni875 – 881Substrate bindingUniRule annotation7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0792, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157211

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001645_7_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QADAMPR

Database of Orthologous Groups

More...
OrthoDBi
96595at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315900

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd13189, FERM_C_PTPN4_PTPN3_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014847, FERM-adjacent
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR041783, PTPN3/4_FERM_C
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR012151, Tyr_Pase_non-rcpt_typ-3/4
IPR000387, TYR_PHOSPHATASE_dom
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08736, FA, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF00595, PDZ, 1 hit
PF00102, Y_phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000927, Tyr-Ptase_nr3, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935, BAND41
PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM01195, FA, 1 hit
SM01196, FERM_C, 1 hit
SM00228, PDZ, 1 hit
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF50156, SSF50156, 1 hit
SSF52799, SSF52799, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS50106, PDZ, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

K7FQE8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLILKTVLV PRCTDLVWTV MTARFRLPAG RTYNVRASEL ARDRQHTEVV
60 70 80 90 100
CNILLLDNTV QAFRVNKHDQ GQVLLDIVFK HLDLTERDYF GLQLADDSTD
110 120 130 140 150
NPRWLDPNKP IRKQLKRGSP YSLNFRVKFF VSDPNKLQEE YTRYQYFLQI
160 170 180 190 200
KQDILTGRLP CPYNTAALLA SYSVQSELGD YSHSENLPGY LSDYSFIPSQ
210 220 230 240 250
PQDFEKEIAK LHHQHIGLSP AEAEFSYLNT ARTLELYGVE LHYARDQSNN
260 270 280 290 300
EIMIGVMSGG ILIYKNRVRI NTFLWLKIVK ISFKCKQFFI QLRKELHESR
310 320 330 340 350
EMLLGFNMVN YRACKNLWKA CVEHHTFFRL DRPLPPQKNF FAHYFTLGSK
360 370 380 390 400
FRYCGRTEVQ SVQYGKEKAN KDRVFARSPS KPLARKLMSG MDWEVVSRNS
410 420 430 440 450
LTDDRLETQS LPSRSPPGTP NHRNSAFTQE RARLRPSSVG HLVDHVVHTS
460 470 480 490 500
PSEVFANHRS PSSTQANSII LESSPSQETP IDGQPPALPP KQSKKNSWNQ
510 520 530 540 550
IHYSHSQQEL DNHINETFDV SSSPEKSTPN GGVPPDNLVL IRMKPDENGR
560 570 580 590 600
FGFNVKGGSD QKMPVIVSRV APGTPADLCV PRLNEGDQVV LINGRDIAEH
610 620 630 640 650
THDEVVMFIK ESCERHSGEL VLLVRPNAVY DVVEEKLESE PDFQYIPEKS
660 670 680 690 700
PLDAVHQDDN ALRESMIQLS EGLITGTILA QFDQLYRKKP GMTMSCAKLP
710 720 730 740 750
QNISKNRYRD ISPYDATRVI LKSNDDYINA NYINMEIPSS SIINQYIACQ
760 770 780 790 800
GPLPNTCPDF WQMTWEQGSS MVVMLTTQVE RGRVKCHQYW PEPTGSSSYG
810 820 830 840 850
NFQIACHSEE GNPAYVFREM TLTNLEKNET RQLTQIQYVA WPDHGVPDDS
860 870 880 890 900
SDFLDFVCLV RKKRAGREEP VVVHCSAGIG RTGVLITMET AMCLIECNQP
910 920 930 940
VYPLDIVRTM RDQRAMMIQT PSQYRFVCEA ILKVYEEGFV KPLKTSLHK
Length:949
Mass (Da):108,501
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i815D4212B83E9554
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AGCU01193640 Genomic DNA No translation available.
AGCU01193641 Genomic DNA No translation available.
AGCU01193642 Genomic DNA No translation available.
AGCU01193643 Genomic DNA No translation available.
AGCU01193644 Genomic DNA No translation available.
AGCU01193645 Genomic DNA No translation available.
AGCU01193646 Genomic DNA No translation available.
AGCU01193647 Genomic DNA No translation available.
AGCU01193648 Genomic DNA No translation available.
AGCU01193649 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006137781.1, XM_006137719.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPSIT00000010310; ENSPSIP00000010258; ENSPSIG00000009317

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102448944

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pss:102448944

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGCU01193640 Genomic DNA No translation available.
AGCU01193641 Genomic DNA No translation available.
AGCU01193642 Genomic DNA No translation available.
AGCU01193643 Genomic DNA No translation available.
AGCU01193644 Genomic DNA No translation available.
AGCU01193645 Genomic DNA No translation available.
AGCU01193646 Genomic DNA No translation available.
AGCU01193647 Genomic DNA No translation available.
AGCU01193648 Genomic DNA No translation available.
AGCU01193649 Genomic DNA No translation available.
RefSeqiXP_006137781.1, XM_006137719.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13735.ENSPSIP00000010258

Genome annotation databases

EnsembliENSPSIT00000010310; ENSPSIP00000010258; ENSPSIG00000009317
GeneIDi102448944
KEGGipss:102448944

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5775

Phylogenomic databases

eggNOGiKOG0792, Eukaryota
GeneTreeiENSGT00940000157211
HOGENOMiCLU_001645_7_0_1
OMAiQADAMPR
OrthoDBi96595at2759
TreeFamiTF315900

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13189, FERM_C_PTPN4_PTPN3_like, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
2.30.42.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014847, FERM-adjacent
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR001478, PDZ
IPR036034, PDZ_sf
IPR011993, PH-like_dom_sf
IPR029021, Prot-tyrosine_phosphatase-like
IPR000242, PTPase_domain
IPR041783, PTPN3/4_FERM_C
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR012151, Tyr_Pase_non-rcpt_typ-3/4
IPR000387, TYR_PHOSPHATASE_dom
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736, FA, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PF00595, PDZ, 1 hit
PF00102, Y_phosphatase, 1 hit
PIRSFiPIRSF000927, Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935, BAND41
PR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01195, FA, 1 hit
SM01196, FERM_C, 1 hit
SM00228, PDZ, 1 hit
SM00194, PTPc, 1 hit
SM00404, PTPc_motif, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF50156, SSF50156, 1 hit
SSF52799, SSF52799, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit
PS50106, PDZ, 1 hit
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50055, TYR_PHOSPHATASE_PTP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7FQE8_PELSI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7FQE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 29, 2021
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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