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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene

COQ7

Organism
Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22Iron 1UniRule annotation1
Metal bindingi52Iron 1UniRule annotation1
Metal bindingi52Iron 2UniRule annotation1
Metal bindingi55Iron 1UniRule annotation1
Metal bindingi104Iron 2UniRule annotation1
Metal bindingi140Iron 1UniRule annotation1
Metal bindingi140Iron 2UniRule annotation1
Metal bindingi143Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processUbiquinone biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Timing protein clk-1 homologUniRule annotation
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
Gene namesi
Name:COQ7UniRule annotationImported
OrganismiPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)Imported
Taxonomic identifieri13735 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraTrionychiaTrionychidaePelodiscus
Proteomesi
  • UP000007267 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4061 Eukaryota
COG2941 LUCA
GeneTreeiENSGT00390000014520
KOiK06134

Family and domain databases

CDDicd01042 DMQH, 1 hit
HAMAPiMF_01658 COQ7, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR011566 Ubq_synth_Coq7
PANTHERiPTHR11237 PTHR11237, 1 hit
PfamiView protein in Pfam
PF03232 COQ7, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit

Sequencei

Sequence statusi: Complete.

K7F8Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLDNINKPD IDRIIRVDHA GEYGANRIYA GQMAVLGRTT VGPVIQQMWN
60 70 80 90 100
QEKDHLKKFN ELMVTFRVRP TILLPFWNVA GFALGAGTAL LGKEGAMACT
110 120 130 140 150
VAVEESISAH YNNQMRTLME EDPEKYKELL QIIKKFRDDE LEHHDIGLDH
160 170
DAELAPAYSL LKTAIQIGCK AAIFLSERI
Length:179
Mass (Da):20,167
Last modified:January 9, 2013 - v1
Checksum:i83A367139BA03CA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGCU01087586 Genomic DNA No translation available.
AGCU01087587 Genomic DNA No translation available.
RefSeqiXP_006123215.1, XM_006123153.2

Genome annotation databases

EnsembliENSPSIT00000004435; ENSPSIP00000004411; ENSPSIG00000004142
GeneIDi102449841
KEGGipss:102449841

Similar proteinsi

Entry informationi

Entry nameiK7F8Q1_PELSI
AccessioniPrimary (citable) accession number: K7F8Q1
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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