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Entry version 42 (02 Jun 2021)
Sequence version 1 (09 Jan 2013)
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Protein

AF-4_C domain-containing protein

Gene

AFF1

Organism
Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AF-4_C domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13735 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraTrionychiaTrionychidaePelodiscus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007267 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13735.ENSPSIP00000003993

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini942 – 1206AF-4_CInterPro annotationAdd BLAST265

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 182DisorderedSequence analysisAdd BLAST31
Regioni211 – 238DisorderedSequence analysisAdd BLAST28
Regioni295 – 316DisorderedSequence analysisAdd BLAST22
Regioni378 – 510DisorderedSequence analysisAdd BLAST133
Regioni528 – 674DisorderedSequence analysisAdd BLAST147
Regioni770 – 816DisorderedSequence analysisAdd BLAST47
Regioni853 – 949DisorderedSequence analysisAdd BLAST97
Regioni1078 – 1114DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi152 – 168Polar residuesSequence analysisAdd BLAST17
Compositional biasi395 – 428Polar residuesSequence analysisAdd BLAST34
Compositional biasi453 – 487Polar residuesSequence analysisAdd BLAST35
Compositional biasi534 – 567Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi568 – 597Polar residuesSequence analysisAdd BLAST30
Compositional biasi633 – 671Basic and acidic residuesSequence analysisAdd BLAST39
Compositional biasi774 – 816Basic and acidic residuesSequence analysisAdd BLAST43
Compositional biasi865 – 899Polar residuesSequence analysisAdd BLAST35
Compositional biasi905 – 927Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1078 – 1097Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVDA, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182974

Identification of Orthologs from Complete Genome Data

More...
OMAi
YMAMFRY

Database of Orthologous Groups

More...
OrthoDBi
558558at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326216

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

K7F7I3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQSSLYNE DRNLLRIRER ERRNQEALQE REPFLENAPL FAEPYKTNKG
60 70 80 90 100
DALSSRIQNM LGSYEEVKEL ISTKLHQNLI GIPKSVVPQI LQGKPDRPFF
110 120 130 140 150
PEKTSSILPT SFQQNNRHQL MGSLAPPSAS NSIHYPKTQS RIEPAASFYT
160 170 180 190 200
KTHTLSSAHS QGSEQRCGGQ ESHHGDCHKK NDSCVDKDRT DELQATLSEL
210 220 230 240 250
SPLLSSLTSP VAPLSPLHSS QHVHSRSQNS DKPHRQTYNR MESPQDLMAG
260 270 280 290 300
LHDKESRDTS AINLVIATQP SSQTFPPALP SKNSAMQQKP TAYVRPMDGQ
310 320 330 340 350
DQAPNESPEL KSLPEDYPGQ PYGKIADLKA NAKAKLSRLK IPSAPIEQTF
360 370 380 390 400
PNEVHCVEEI LKEMTHSWPP PLTAIHTPST AEPSKFPFPI KESQRVGSVI
410 420 430 440 450
QSRKQCDAPS KRLPTSQQGT SMLQDDLQLS DSEDSDDDQV SEKPPPSSAP
460 470 480 490 500
PSVLQSQPEG VASAHSSSAE SGSTSDSDSS SDSESESGLS DSEAKEPPRI
510 520 530 540 550
STSEPYPLTS NKWQLDNWLT KVNQPTVPTE NLCDVSHRHG HQESKGQGKR
560 570 580 590 600
SSSSSHEHSE SNELHSKNSS KTTRIPQVVH LPSKQTYQKS PLCTEEPTQR
610 620 630 640 650
HTVGIKKPCK NPLQEAHRAS VKVKGNPGPY GVKEHSSRDK PKVKTKERPK
660 670 680 690 700
STDKMELKRT GQEPLEKKKH KNPHQAITKT FLDPKSVKDI MSGSASEHFP
710 720 730 740 750
LSPIAQGQTF TRTSGKKTAI VVKEDFHRDR LILPIRDKKL LSPLRDSPVP
760 770 780 790 800
HALVVKIELC LLSRIPQPLG KGSHPKKLEG KELPCTRKQD FEKRSTDSLH
810 820 830 840 850
KSLKKRKGEV EKETDKKKIK LEKETKSLLS SSHKDFSKMK GCKFPSETLK
860 870 880 890 900
KELLLPPPLP PMSTIQPAQK QAQKGHKGET STCSQLFVTS NGNAKSKSNH
910 920 930 940 950
KDSSSSKHRK MEGKLSEHSK SNKESSGDVK NRFPMPSLPN GTSKPKRPQI
960 970 980 990 1000
KFEKQHPMEY HIEEAKRLKH KADTMTDKVA KAFQYLEAAL SFIEYGISME
1010 1020 1030 1040 1050
SDALAPKSAY TIFSDTIDLL KFIMTLKSFS DTSASAHEKI FAVLCMRCQS
1060 1070 1080 1090 1100
ILHMAMFRYK KDTAVKYSRT LNEHFKNSSR VTQAPSPCVA RSTGTPSPLS
1110 1120 1130 1140 1150
PMPSPASSVS SQSGSNASNC GSGVICSSIN TLHNIPSITF SYINITSYIL
1160 1170 1180 1190 1200
CAYDIWEQAD ALTRKNKEFF AELSTAVCTL ALNSGLIDLV HYTRQGLQWL

KLETKMP
Length:1,207
Mass (Da):133,997
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i799A581D52C7C91C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7F7H9K7F7H9_PELSI
AF-4_C domain-containing protein
AFF1
1,186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AGCU01034610 Genomic DNA No translation available.
AGCU01034611 Genomic DNA No translation available.
AGCU01034612 Genomic DNA No translation available.
AGCU01034613 Genomic DNA No translation available.
AGCU01034614 Genomic DNA No translation available.
AGCU01034615 Genomic DNA No translation available.
AGCU01034616 Genomic DNA No translation available.
AGCU01034617 Genomic DNA No translation available.
AGCU01034618 Genomic DNA No translation available.
AGCU01034619 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006115397.1, XM_006115335.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSPSIT00000004015; ENSPSIP00000003993; ENSPSIG00000003759

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102459614

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGCU01034610 Genomic DNA No translation available.
AGCU01034611 Genomic DNA No translation available.
AGCU01034612 Genomic DNA No translation available.
AGCU01034613 Genomic DNA No translation available.
AGCU01034614 Genomic DNA No translation available.
AGCU01034615 Genomic DNA No translation available.
AGCU01034616 Genomic DNA No translation available.
AGCU01034617 Genomic DNA No translation available.
AGCU01034618 Genomic DNA No translation available.
AGCU01034619 Genomic DNA No translation available.
RefSeqiXP_006115397.1, XM_006115335.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13735.ENSPSIP00000003993

Genome annotation databases

EnsembliENSPSIT00000004015; ENSPSIP00000003993; ENSPSIG00000003759
GeneIDi102459614

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4299

Phylogenomic databases

eggNOGiENOG502QVDA, Eukaryota
GeneTreeiENSGT00950000182974
OMAiYMAMFRY
OrthoDBi558558at2759
TreeFamiTF326216

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7F7I3_PELSI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7F7I3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: June 2, 2021
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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