Proto-oncogene c-Jun

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cAMP response element binding Source: Ensembl
• chromatin binding Source: Ensembl
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
• GTPase activator activity Source: Ensembl
• identical protein binding Source: Ensembl
• RNA polymerase II activating transcription factor binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

• angiogenesis Source: Ensembl
• axon regeneration Source: Ensembl
• cellular response to cadmium ion Source: Ensembl
• cellular response to calcium ion Source: Ensembl
• cellular response to reactive oxygen species Source: Ensembl
• eyelid development in camera-type eye Source: Ensembl
• leading edge cell differentiation Source: Ensembl
• liver development Source: Ensembl
• microglial cell activation Source: Ensembl
• monocyte differentiation Source: Ensembl
• negative regulation by host of viral transcription Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of DNA binding Source: Ensembl
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of protein autophosphorylation Source: Ensembl
• negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: Ensembl
• outflow tract morphogenesis Source: Ensembl
• positive regulation by host of viral transcription Source: Ensembl
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of DNA-templated transcription, initiation Source: Ensembl
• positive regulation of endothelial cell proliferation Source: Ensembl
• positive regulation of epithelial cell migration Source: Ensembl
• positive regulation of ERK1 and ERK2 cascade Source: Ensembl
• positive regulation of fibroblast proliferation Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
• Ras protein signal transduction Source: Ensembl
• regulation of cell cycle Source: Ensembl
• response to drug Source: Ensembl
• response to muscle stretch Source: Ensembl
• SMAD protein signal transduction Source: Ensembl
• transforming growth factor beta receptor signaling pathway Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: Ensembl
• RNA polymerase II activating transcription factor binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTAKMEPTFY DDALNATFVQ PESGGYGYNN PKVLKQNMTL NLADPSSNLK 
        60         70         80         90        100
PHLRNKNADI LTSPDVGLLK LASPELERLI IQSSNGLITT TPTPTQFLCP 
       110        120        130        140        150
KNVTDEQEGF AEGFVRALAE LHNQNTMPSV TTAAQPVSSG MTPVSSMAGN 
       160        170        180        190        200
NGFNTSLHSE PPVYANLSNF NPSALSTAPN YNANNMGYPP QHHINPQMPV 
       210        220        230        240        250
QHPRLQALKE EPQTVPEMPG ETPPLSPIDM ESQERIKAER KRMRNRIAAS 
       260        270        280        290        300
KCRKRKLERI ARLEEKVKTL KAQNSELAST ANMLREQVAQ LKQKVMNHVN 
       310 
SGCQLMLTQQ LQTF                                        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ