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Protein
Submitted name:

Protein strawberry notch homolog 2

Gene

SBNO2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein strawberry notch homolog 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SBNO2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000064932.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29158 SBNO2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000064932

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
K7ES28

MaxQB - The MaxQuant DataBase

More...
MaxQBi
K7ES28

PeptideAtlas

More...
PeptideAtlasi
K7ES28

PRoteomics IDEntifications database

More...
PRIDEi
K7ES28

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064932 Expressed in 178 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
K7ES28 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini215 – 505AAA_34InterPro annotationAdd BLAST291
Domaini722 – 1000Helicase_C_4InterPro annotationAdd BLAST279

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili698 – 718Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1513 Eukaryota
ENOG410XQ7Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159946

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR030410 SBNO2
IPR026937 SBNO_Helicase_C_dom
IPR026741 SNO
IPR039187 SNO_AAA

The PANTHER Classification System

More...
PANTHERi
PTHR12706 PTHR12706, 1 hit
PTHR12706:SF5 PTHR12706:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13872 AAA_34, 1 hit
PF13871 Helicase_C_4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

K7ES28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAVGPAMDR DYPQHEPPPA GSLLYSPPPL QSAMLHCPYW NTFSLPPYPA
60 70 80 90 100
FSSDSRPFMS SASFLGSQPC PDTSYAPVAT ASSLPPKTCD FAQDSSYFED
110 120 130 140 150
FSNISIFSSS VDSLSDIVDT PDFLPADSLN QVSTIWDDNP APSTHDKLFQ
160 170 180 190 200
LSRPFAGFED FLPSHSTPLL VSYQEQSVQS QPEEEDEAEE EEAEELGHTE
210 220 230 240 250
TYADYVPSKS KIGKQHPDRV VETSTLSSVP PPDITYTLAL PSDSGALSAL
260 270 280 290 300
QLEAITYACQ QHEVLLPSGQ RAGFLIGDGA GVGKGRTVAG VILENHLRGR
310 320 330 340 350
KKALWFSVSN DLKYDAERDL RDIEATGIAV HALSKIKYGD TTTSEGVLFA
360 370 380 390 400
TYSALIGESQ AGGQHRTRLR QILDWCGEAF EGVIVFDECH KAKNAGSTKM
410 420 430 440 450
GKAVLDLQNK LPLARVVYAS ATGASEPRNM IYMSRLGIWG EGTPFRNFEE
460 470 480 490 500
FLHAIEKRGV GAMEIVAMDM KVSGMYIARQ LSFSGVTFRI EEIPLAPAFE
510 520 530 540 550
CVYNRAALLA ADWIGLESRK SLWGQFWSAH QRFFKYLCIA AKVRRLVELA
560 570 580 590 600
REELARDKCV VIGLQSTGEA RTREVLGEND GHLNCFVSAA EGVFLSLIQK
610 620 630 640 650
HFPSTKRKRD RGAGSKRKRR PRGRGAKAPR LACETAGVIR ISDDSSTESD
660 670 680 690 700
PGLDSDFNSS PESLVDDDVV IVDAVGLPSD DRGPLCLLQR DPHGPGVLER
710 720 730 740 750
VERLKQDLLD KVRRLGRELP VNTLDELIDQ LGGPQRVAEM TGRKGRVVSR
760 770 780 790 800
PDGTVAFESR AEQGLSIDHV NLREKQRFMS GEKLVAIISE ASSSGVSLQA
810 820 830 840 850
DRRVQNQRRR VHMTLELPWS ADRAIQQFGR THRSNQVSAP EYVFLISELA
860 870 880 890 900
GERRFASIVA KRLESLGALT HGDRRATESR DLSKYNFENK YGTRALHCVL
910 920 930 940 950
TTILSQTENK VPVPQGYPGG VPTFFRDMKQ GLLSVGIGGR ESRNGCLDVE
960 970 980 990 1000
KDCSITKFLN RILGLEVHKQ NALFQYFSDT FDHLIEMDKR EGKYDMGILD
1010 1020 1030 1040 1050
LAPGIEEIYE ESQQVFLAPG HPQDGQVVFY KISVDRGLKW EDAFAKSLAL
1060 1070 1080 1090 1100
TGPYDGFYLS YKVRGNKPSC LLAEQNRGQF FTVYKPNIGR QSQLEALDSL
1110 1120 1130 1140 1150
RRKFHRVTAE EAKEPWESGY ALSLTHCSHS AWNRHCRLAQ EGKDCLQGLR
1160 1170 1180 1190 1200
LRHHYMLCGA LLRVWGRIAA VMADVSSSSY LQIVRLKTKD RKKQVGIKIP
1210 1220 1230 1240 1250
EGCVRRVLQE LRLMDADVKR RQAPALGCPA PPAPRPLALP CGPGEVLDLT
1260 1270 1280 1290 1300
YSPPAEAFPP PPHFSFPAPL SLDAGPGVVP LGTPDAQADP AALAHQGCDI
1310 1320 1330 1340 1350
NFKEVLEDML RSLHAGPPSE GALGEGAGAG GAAGGGPERQ SVIQFSPPFP

GAQAPL
Length:1,356
Mass (Da):149,088
Last modified:January 9, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC67663405DC35D4C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y2G9SBNO2_HUMAN
Protein strawberry notch homolog 2
SBNO2 KIAA0963
1,366Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERL2K7ERL2_HUMAN
Protein strawberry notch homolog 2
SBNO2
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENA9K7ENA9_HUMAN
Protein strawberry notch homolog 2
SBNO2
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005390 Genomic DNA No translation available.
AC093067 Genomic DNA No translation available.
AC120982 Genomic DNA No translation available.
AC217140 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000587024; ENSP00000468520; ENSG00000064932
ENST00000634172; ENSP00000488286; ENSG00000278788

UCSC genome browser

More...
UCSCi
uc060qvz.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005390 Genomic DNA No translation available.
AC093067 Genomic DNA No translation available.
AC120982 Genomic DNA No translation available.
AC217140 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Proteomic databases

EPDiK7ES28
MaxQBiK7ES28
PeptideAtlasiK7ES28
PRIDEiK7ES28

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587024; ENSP00000468520; ENSG00000064932
ENST00000634172; ENSP00000488286; ENSG00000278788
UCSCiuc060qvz.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000064932.15
HGNCiHGNC:29158 SBNO2
OpenTargetsiENSG00000064932

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1513 Eukaryota
ENOG410XQ7Q LUCA
GeneTreeiENSGT00940000159946

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SBNO2 human

Gene expression databases

BgeeiENSG00000064932 Expressed in 178 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiK7ES28 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030410 SBNO2
IPR026937 SBNO_Helicase_C_dom
IPR026741 SNO
IPR039187 SNO_AAA
PANTHERiPTHR12706 PTHR12706, 1 hit
PTHR12706:SF5 PTHR12706:SF5, 1 hit
PfamiView protein in Pfam
PF13872 AAA_34, 1 hit
PF13871 Helicase_C_4, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK7ES28_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: K7ES28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: December 5, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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