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Protein
Submitted name:

(E3-independent) E2 ubiquitin-conjugating enzyme

Gene

UBE2O

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
(E3-independent) E2 ubiquitin-conjugating enzymeImported
Gene namesi
Name:UBE2OImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000175931.12
HGNCiHGNC:29554 UBE2O

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175931

PTM / Processingi

Proteomic databases

EPDiK7ES11
MaxQBiK7ES11
PeptideAtlasiK7ES11
PRIDEiK7ES11

Expressioni

Gene expression databases

BgeeiENSG00000175931 Expressed in 185 organ(s), highest expression level in cerebellum
ExpressionAtlasiK7ES11 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiK7ES11, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliK7ES11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 592UBIQUITIN_CONJUGAT_2InterPro annotationAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili365 – 392Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0895 Eukaryota
ENOG410XQ7W LUCA
GeneTreeiENSGT00730000110680

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

K7ES11-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XTDDTSSVTS SASSTTSSQS GSGTSRKKSI PLSIKNLKRK HKRKKNKITR
60 70 80 90 100
DFKPGDRVAV EVVTTMTSAD VMWQDGSVEC NIRSNDLFPV HHLDNNEFCP
110 120 130 140 150
GDFVVDKRVQ SCPDPAVYGV VQSGDHIGRT CMVKWFKLRP SGDDVELIGE
160 170 180 190 200
EEDVSVYDIA DHPDFRFRTT DIVIRIGNTE DGAPHKEDEQ PSVGQVARVD
210 220 230 240 250
VSSKVEVVWA DNSKTIILPQ HLYNIESEIE ESDYDSVEGS TSGASSDEWE
260 270 280 290 300
DDSDSWETDN GLVEDEHPKI EEPPIPPLEQ PVAPEDKGVV ISEEAATAAV
310 320 330 340 350
QGAVAMAAPM AGLMEKAGKD GPPKSFRELK EAIKILESLK NMTVEQLLTG
360 370 380 390 400
SPTSPTVEPE KPTREKKFLD DIKKLQENLK KTLDNVAIVE EEKMEAVPDV
410 420 430 440 450
ERKEDKPEGQ SPVKAEWPSE TPVLCQQCGG KPGVTFTSAK GEVFSVLEFA
460 470 480 490 500
PSNHSFKKIE FQPPEAKKFF STVRKEMALL ATSLPEGIMV KTFEDRMDLF
510 520 530 540 550
SALIKGPTRT PYEDGLYLFD IQLPNIYPAV PPHFCYLSQC SGRLNPNLYD
560 570 580 590 600
NGKVCVSLLG TWIGKGTERW TSKSSLLQVL ISIQGLILVN EPYYNEAGFD
610 620 630 640 650
SDRGLQEGYE NSRCYNEMAL IRVVQSMTQL VRRPPEVFEQ EIRQHFSTGG
660 670 680 690 700
WRLVNRIESW LETHALLEKA QALPNGVPKA SSSPEPPAVA ELSDSGQQEP
710 720 730 740 750
EDGGPAPGEA SQGSDSEGGA QGLASASRDH TDQTSETAPD ASVPPSVKPK
760 770 780 790 800
KRRKSYRSFL PEKSGYPDIG FPLFPLSKGF IKSIRGVLTQ FRAALLEAGM

PECTEDK
Length:807
Mass (Da):88,862
Last modified:January 9, 2013 - v1
Checksum:i84937DD50AED2B18
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9C0C9UBE2O_HUMAN
(E3-independent) E2 ubiquitin-conju...
UBE2O KIAA1734
1,292Annotation score:
K7EQ12K7EQ12_HUMAN
(E3-independent) E2 ubiquitin-conju...
UBE2O
189Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015802 Genomic DNA No translation available.
AC090699 Genomic DNA No translation available.
KF456323 Genomic DNA No translation available.
KF510428 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000587127; ENSP00000468498; ENSG00000175931
UCSCiuc060kja.1 human

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC015802 Genomic DNA No translation available.
AC090699 Genomic DNA No translation available.
KF456323 Genomic DNA No translation available.
KF510428 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7ES11
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiK7ES11, 1 interactor

Proteomic databases

EPDiK7ES11
MaxQBiK7ES11
PeptideAtlasiK7ES11
PRIDEiK7ES11

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000587127; ENSP00000468498; ENSG00000175931
UCSCiuc060kja.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000175931.12
HGNCiHGNC:29554 UBE2O
OpenTargetsiENSG00000175931
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0895 Eukaryota
ENOG410XQ7W LUCA
GeneTreeiENSGT00730000110680

Miscellaneous databases

ChiTaRSiUBE2O human

Gene expression databases

BgeeiENSG00000175931 Expressed in 185 organ(s), highest expression level in cerebellum
ExpressionAtlasiK7ES11 baseline and differential

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7ES11_HUMAN
AccessioniPrimary (citable) accession number: K7ES11
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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