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Protein
Submitted name:

Thioredoxin-like protein 1

Gene

TXNL1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Thioredoxin-like protein 1Imported
Gene namesi
Name:TXNL1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000091164.12
HGNCiHGNC:12436 TXNL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000091164

PTM / Processingi

Proteomic databases

MaxQBiK7ER96
PeptideAtlasiK7ER96
PRIDEiK7ER96

Expressioni

Gene expression databases

BgeeiENSG00000091164 Expressed in 239 organ(s), highest expression level in thyroid gland
ExpressionAtlasiK7ER96 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliK7ER96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 281PITHInterPro annotationAdd BLAST171

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

K7ER96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XPVGSDPDFQ PELSGAGSRL AVVKFTMRGC GPCLRIAPAF SSMSNKYPQA
60 70 80 90 100
VFLEVDVHQC QGTAATNNIS ATPTFLFFRN KVRIDQYQGA DAVGLEEKIK
110 120 130 140 150
QHLENDPGSN EDTDIPKGYM DLMPFINKAG CECLNESDEH GFDNCLRKDT
160 170 180 190 200
TFLESDCDEQ LLITVAFNQP VKLYSMKFQG PDNGQGPKYV KIFINLPRSM
210 220 230 240 250
DFEEAERSEP TQALELTEDD IKEDGIVPLR YVKFQNVNSV TIFVQSNQGE
260 270 280
EETTRISYFT FIGTPVQATN MNDFKRVSLL K
Length:281
Mass (Da):31,467
Last modified:January 9, 2013 - v1
Checksum:i2C5AAA99E58DC0F6
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O43396TXNL1_HUMAN
Thioredoxin-like protein 1
TXNL1 TRP32, TXL, TXNL
289Annotation score:
K7EML9K7EML9_HUMAN
Thioredoxin-like protein 1
TXNL1
138Annotation score:
K7EPB7K7EPB7_HUMAN
Thioredoxin-like protein 1
TXNL1
69Annotation score:
K7EME7K7EME7_HUMAN
Thioredoxin-like protein 1
TXNL1
103Annotation score:
K7EKG2K7EKG2_HUMAN
Thioredoxin-like protein 1
TXNL1
27Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007052 Genomic DNA No translation available.
KF456423 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000586262; ENSP00000468165; ENSG00000091164
UCSCiuc060pll.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007052 Genomic DNA No translation available.
KF456423 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliK7ER96
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiK7ER96
PeptideAtlasiK7ER96
PRIDEiK7ER96

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000586262; ENSP00000468165; ENSG00000091164
UCSCiuc060pll.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000091164.12
HGNCiHGNC:12436 TXNL1
OpenTargetsiENSG00000091164
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008

Miscellaneous databases

ChiTaRSiTXNL1 human

Gene expression databases

BgeeiENSG00000091164 Expressed in 239 organ(s), highest expression level in thyroid gland
ExpressionAtlasiK7ER96 baseline and differential

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK7ER96_HUMAN
AccessioniPrimary (citable) accession number: K7ER96
Entry historyiIntegrated into UniProtKB/TrEMBL: January 9, 2013
Last sequence update: January 9, 2013
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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